Obiettivo Today' s population is increasingly exposed to ultrafine particles (<20 nm; e.g. Aerosil, TiO2) contained in body care and household products. Tape stripping studies and recent ion microscopy pilot studies revealed that such particles in, liposomal formulations penetrate the horny layer with large concentrations at the stratum granulosum and the possible risk of further penetration into vital tissue, especially for skin with an impaired barrier function. Here, apart from electron microscopy, high-resolution ion-microscopy techniques will be employed on skin cross-sections from biopsies (pig, human), which yield elemental maps of both the epidermis and dermis with ppm sensitivity for Ti or higher sensitivity with radiotracers (labelled TiO2) on pig skin. Pathways for percutaneous uptake and clearance will be studied. If such particles penetrate into the dermis, in-situ studies of tissue and in-vitro studies of particle-cell interactions follows. Campo scientifico natural sciencesphysical sciencesopticsmicroscopyelectron microscopy Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) 1.1.1.-4. - Key action Environment and Health Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore UNIVERSITAET LEIPZIG Contributo UE Nessun dato Indirizzo Linnestrasse 5 04103 LEIPZIG Germania Mostra sulla mappa Costo totale Nessun dato Partecipanti (6) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Francia Contributo UE Nessun dato Indirizzo Rue Michel Ange 3 75794 PARIS Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato INSTITUTO TECNOLOGICO E NUCLEAR Portogallo Contributo UE Nessun dato Indirizzo Estrada Nacional 10 2686-953 SACAVEM Mostra sulla mappa Costo totale Nessun dato JAGIELLONIAN UNIVERSITY Polonia Contributo UE Nessun dato Indirizzo St..Anna's street 8 31 008 KRAKOW Mostra sulla mappa Costo totale Nessun dato THE HENRYK NIEWODNICZANSKI INSTITUTE OF NUCLEAR PHYSICS Polonia Contributo UE Nessun dato Indirizzo 152,Radzikowskiego 152 31 342 KRAKOW Mostra sulla mappa Costo totale Nessun dato UNIVERSITE DE BORDEAUX I Francia Contributo UE Nessun dato Indirizzo Cours de la Libération 351 33405 TALENCE Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF DEBRECEN Ungheria Contributo UE Nessun dato Indirizzo Nagyerdei krt. 98 4012 DEBRECEN Mostra sulla mappa Costo totale Nessun dato
