Obiettivo Background Ixodes ricinus transmits bacterial, protozoal and viral pathogens that cause Lyme borreliosis, babesiosis and tick-borne encephalitis respectively and exceedingly affect Central and Eastern Europe (CEE). During feeding, ticks introduce salivary proteins in the skin that interfere with host defense mechanisms. However, in animals repeated tick infestations as well as vaccination against selected tick proteins can lead to decreased pathogen transmission by inhibiting tick feeding - known as ‘tick immunity’ - or by neutralizing tick proteins that facilitate the transmission of tick-borne pathogens (TBPs). Also humans with hypersensitivity to tick-bites have a lower risk of contracting tick-borne diseases (TBDs). Therefore, anti-tick vaccines encompass an innovative strategy to prevent TBDs in humans, or animals and wildlife to indirectly reduce the risk of contracting TBDs for humans.Overall Objective To identify and characterize tick proteins involved in ‘tick immunity’ and TBP transmission and to use this knowledge to develop anti-tick vaccines to prevent multiple human TBDs.Methods Using state of the art proteomic and transcriptomic approaches we will identify and characterize novel tick salivary gland proteins, which will be subsequently assessed as anti-tick vaccines to protect against LB, babesiosis and TBE in animal models. In addition, through an integrated and multidisciplinary approach involving CEE public health institutes, health organizations and industrial companies we will examine how to develop anti-tick vaccines and implement these in public health systems.Impact ANTIDotE will deliver 1) essential knowledge on the biological mechanisms involved in the pathogenesis of TBDs, 2) proof of concept of an anti-tick vaccine protecting against multiple human TBPs and 3) plans for exploitation and implementation of anti-tick vaccines, significantly contributing to downscaling the severe medical and economic burden that TBDs have on societies. Campo scientifico medical and health scienceshealth sciencespublic healthnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programma(i) FP7-HEALTH - Specific Programme "Cooperation": Health Argomento(i) HEALTH.2013.2.3.4-1 - Neglected infectious diseases of Central and Eastern Europe Invito a presentare proposte FP7-HEALTH-2013-INNOVATION-1 Vedi altri progetti per questo bando Meccanismo di finanziamento CP-FP - Small or medium-scale focused research project Coordinatore ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Contributo UE € 988 320,00 Indirizzo MEIBERGDREEF 15 1105AZ Amsterdam Paesi Bassi Mostra sulla mappa Regione West-Nederland Noord-Holland Groot-Amsterdam Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Frank Groen (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (7) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto VIROLOGICKY USTAV SLOVENSKEJ AKADEMIE VIED Partecipazione conclusa Slovacchia Contributo UE Nessun dato Indirizzo Dubravska Cesta 9 84505 BRATISLAVA Mostra sulla mappa Tipo di attività Research Organisations Contatto amministrativo Hana Krasoňová (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato BIOLOGICKE CENTRUM AKADEMIE VID CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE Cechia Contributo UE € 565 900,00 Indirizzo BRANISOVSKA 1160/31 370 05 Ceske Budejovice Mostra sulla mappa Regione Česko Jihozápad Jihočeský kraj Tipo di attività Research Organisations Contatto amministrativo Zdenka Grufikova (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato FREIE UNIVERSITAET BERLIN Germania Contributo UE € 466 100,00 Indirizzo KAISERSWERTHER STRASSE 16-18 14195 Berlin Mostra sulla mappa Regione Berlin Berlin Berlin Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Annegret Körner (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS Spagna Contributo UE € 373 400,00 Indirizzo PARQUE TECNOLOGICO EDIFICIO 801 A 48160 Derio Vizcaya Mostra sulla mappa Regione Noreste País Vasco Bizkaia Tipo di attività Research Organisations Contatto amministrativo Alfonso Egaña (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato GENXPRO GMBH Germania Contributo UE € 208 700,00 Indirizzo ALTENHOFTER ALLEE 3 60438 Frankfurt Mostra sulla mappa Regione Hessen Darmstadt Frankfurt am Main, Kreisfreie Stadt Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Cornelia Lenhart (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU Paesi Bassi Contributo UE € 141 445,00 Indirizzo Antonie Van Leeuwenhoeklaan 9 3721 MA Bilthoven Mostra sulla mappa Regione West-Nederland Utrecht Utrecht Tipo di attività Research Organisations Contatto amministrativo Marjon Hartwigsen (Mrs.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato BIOMEDICINSKE CENTRUM SLOVENSKEJ AKADEMIE VIED, VEREJNA VYSKUMNA INSTITUCIA Slovacchia Contributo UE € 255 920,00 Indirizzo DUBRAVSKA CESTA 9 845 05 Bratislava Mostra sulla mappa Regione Slovensko Bratislavský kraj Bratislavský kraj Tipo di attività Research Organisations Contatto amministrativo Hana Krasoňová (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato
