Cel The aim of this Fellowship is for the researcher, Dr Karen Dixon, to receive advanced training, develop interdisciplinary skills with high-impact dissemination, and practical experience in line with a leading independent researcher in the EU. The remit of the Fellowship proposal falls under the category of Immunology- autoimmunity and TH17 cell biology. The researcher will be based for two years in the laboratory of Professor Vijay Kuchroo at Brigham & Women`s Hospital. The third year of the Fellowship will be completed in the Department of Biochemistry & Immunology, Trinity College Dublin (TCD) working under the supervision of Professor Kingston Mills. Research training will be implemented through an interdisciplinary project investigating the mechanism by which IL-23 regulates the development of pathogenic vs non-pathogenic TH17 cells. On the outgoing phase of the Fellowship, the researcher will access expertise, state-of-the-art training and mentoring in deciphering the heterogeneity of TH17 cells using advanced transcriptional analysis. In the return phase the researcher will consolidate the knowledge and experience gained in the US through further laboratory training in IL-17 mediated disease. In TCD she will be given the opportunity to embed her new knowledge in Ireland through mentoring and teaching in the host institute. This includes practical seminars on state of the art technology including single cell RNA-seq and NanoString technology. Under the guidance of international experts, she will acquire an invaluable skillset using the latest technical advances to decode heterogeneous populations in immune mediated diseases. The resources of the host departments will facilitate development of an interdisciplinary and international academic network as well as career-mentoring. With increasing recognition of the functional heterogeneity within cell populations, this Fellowship will establish the researcher firmly at the centre of immunological research in the EU. Dziedzina nauki natural sciencesbiological sciencesbiochemistrynatural sciencesbiological sciencescell biologymedical and health sciencesbasic medicineneurologymultiple sclerosismedical and health sciencesbasic medicineimmunology Słowa kluczowe Multiple Sclerosis IL-12 family IL-23R T helper 17 heterogeneity pathogenic versus non-pathogenic serum glucocorticoid kinase 1 (SGK1) CD5L Program(-y) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Temat(-y) MSCA-IF-2015-GF - Marie Skłodowska-Curie Individual Fellowships (IF-GF) Zaproszenie do składania wniosków H2020-MSCA-IF-2015 Zobacz inne projekty w ramach tego zaproszenia System finansowania MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF) Koordynator THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN Wkład UE netto € 248 063,40 Adres COLLEGE GREEN TRINITY COLLEGE D02 CX56 DUBLIN 2 Irlandia Zobacz na mapie Region Ireland Eastern and Midland Dublin Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 248 063,40 Partnerzy (1) Sortuj alfabetycznie Sortuj według wkładu UE netto Rozwiń wszystko Zwiń wszystko Partner Organizacje partnerskie biorą udział w realizacji działania, jednak nie podpisują umowy o grant. BRIGHAM INC Stany Zjednoczone Wkład UE netto € 0,00 Adres FRANCIS STREET 75 02115 BOSTON MA Zobacz na mapie Rodzaj działalności Research Organisations Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 160 130,40
