CORDIS
EU research results

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Evaluation of ratioNally Designed Influenza vaccines

Project information

Grant agreement ID: 874650

Status

Ongoing project

  • Start date

    1 April 2020

  • End date

    31 March 2025

Funded under:

H2020-EU.3.1.2.

  • Overall budget:

    € 14 444 867,50

  • EU contribution

    € 8 646 254,25

Coordinated by:

STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER

Germany

Project description

English EN

Rational design of influenza vaccine

The EU-funded ENDFLU project aims to develop three next-generation influenza vaccination strategies, capitalising on the expertise of European and Indian partners in rational vaccine design and development. Constructs to elicit humoral immunity build on rationally designed and optimised conserved epitopes of influenza surface proteins, hemagglutinin stem- and head-nanoparticles, and matrix protein 2 ectodomain and influenza neuraminidase fusions either as proteins or expressed as replication-deficient modified vaccinia virus Ankara (MVA). Other MVA-based constructs to elicit cell-mediated immunity will encode internal protein T-cell epitopes, as an artificial poly-epitope. The best candidates selected in the preclinical trials will enter a phase I clinical trial in India assessing safety, immunogenicity and optimal dose. The MVA-based constructs will enter a clinical trial in the EU, assessing safety and immunogenicity, followed by a controlled human infection model study.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER

Address

Bunteweg 2
30559 Hannover

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 234 225

Participants (13)

INDIAN INSTITUTE OF SCIENCE

India

VIB

Belgium

EU Contribution

€ 608 750

LUNDS UNIVERSITET

Sweden

EU Contribution

€ 360 925

TRANSLATIONAL HEALTH SCIENCE AND TECHNOLOGY INSTITUTE

India

UNIVERSITEIT UTRECHT

Netherlands

EU Contribution

€ 435 707,50

INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH THIRUVANANTHAPURAM

India

MANIPAL ACADEMY OF HIGHER EDUCATION

India

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

EU Contribution

€ 2 342 075

SETH G S M COLLEGE AND K E M HOSPITAL DIAMOND JUBILEE SOCIETY

India

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

Switzerland

EU Contribution

€ 300 000

COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

India

MYNVAX PRIVATE LIMITED

India

CR2O BV

Netherlands

EU Contribution

€ 3 364 571,75

Project information

Grant agreement ID: 874650

Status

Ongoing project

  • Start date

    1 April 2020

  • End date

    31 March 2025

Funded under:

H2020-EU.3.1.2.

  • Overall budget:

    € 14 444 867,50

  • EU contribution

    € 8 646 254,25

Coordinated by:

STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER

Germany