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Evaluation of ratioNally Designed Influenza vaccines

Project description

Rational design of influenza vaccine

The EU-funded ENDFLU project aims to develop three next-generation influenza vaccination strategies, capitalising on the expertise of European and Indian partners in rational vaccine design and development. Constructs to elicit humoral immunity build on rationally designed and optimised conserved epitopes of influenza surface proteins, hemagglutinin stem- and head-nanoparticles, and matrix protein 2 ectodomain and influenza neuraminidase fusions either as proteins or expressed as replication-deficient modified vaccinia virus Ankara (MVA). Other MVA-based constructs to elicit cell-mediated immunity will encode internal protein T-cell epitopes, as an artificial poly-epitope. The best candidates selected in the preclinical trials will enter a phase I clinical trial in India assessing safety, immunogenicity and optimal dose. The MVA-based constructs will enter a clinical trial in the EU, assessing safety and immunogenicity, followed by a controlled human infection model study.

Call for proposal

H2020-SC1-BHC-2018-2020

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Sub call

H2020-SC1-2019-Single-Stage-RTD

Coordinator

STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER
Net EU contribution
€ 1 234 225,00
Address
Bunteweg 2
30559 Hannover
Germany

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Region
Niedersachsen Hannover Region Hannover
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (13)

INDIAN INSTITUTE OF SCIENCE
India
Net EU contribution
€ 0,00
Address
Cross Malleshwaram 18
560012 Bangalore

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 1 424 948,25
VIB VZW
Belgium
Net EU contribution
€ 608 750,00
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent

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Region
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Activity type
Research Organisations
Non-EU contribution
€ 0,00
LUNDS UNIVERSITET
Sweden
Net EU contribution
€ 360 925,00
Address
Paradisgatan 5c
22100 Lund

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Region
Södra Sverige Sydsverige Skåne län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
TRANSLATIONAL HEALTH SCIENCE AND TECHNOLOGY INSTITUTE
India
Net EU contribution
€ 0,00
Address
Ncr Biotech Science Cluster 3rd Milestone Haryana
121001 Faridabad

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Activity type
Research Organisations
Non-EU contribution
€ 1 274 938,75
UNIVERSITEIT UTRECHT
Netherlands
Net EU contribution
€ 435 707,50
Address
Heidelberglaan 8
3584 CS Utrecht

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Region
West-Nederland Utrecht Utrecht
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH THIRUVANANTHAPURAM
India
Net EU contribution
€ 0,00
Address
Maruthamala Po Vithura
695016 Thiruvananthapuram

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 294 180,00
MANIPAL ACADEMY OF HIGHER EDUCATION
India
Net EU contribution
€ 0,00
Address
Manipal Edu Madhav Nagar
576 104 Manipal

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 773 575,00
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
Net EU contribution
€ 2 342 075,00
Address
Geschwister Scholl Platz 1
80539 Muenchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
SETH G S M COLLEGE AND K E M HOSPITAL DIAMOND JUBILEE SOCIETY
India
Net EU contribution
€ 0,00
Address
Acharya Donde Marg Parel
400012 Mumbai

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Activity type
Research Organisations
Non-EU contribution
€ 437 251,25
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
Net EU contribution
€ 300 000,00
Address
Batiment Ce 3316 Station 1
1015 Lausanne

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Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
India
Net EU contribution
€ 0,00
Non-EU contribution
€ 474 095,00
MYNVAX PRIVATE LIMITED
India
Net EU contribution
€ 0,00
Address
399 17th Main Road 36th Cross 4th T Block Jayanagar
560041 Bangladore

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 119 625,00
CR2O BV
Netherlands
Net EU contribution
€ 3 364 571,75
Address
Bisonspoor 3002, C701
3605 LT Maarssen

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
West-Nederland Utrecht Utrecht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00