Project description
New useful molecules from meta-selective activation of arenes
Carbonylative meta carbon–hydrogen (C–H) activation protocols based on the use of carbon monoxide (CO) within environmentally friendly strategies, can lead to new, complex and very useful molecules. Unlike the ortho-C–H acylation of arenes and heteroarenes and Friedel–Crafts acylation, the meta-selective C–H acylation of arenes remains poorly explored. The EU-funded METACYL project plans to demonstrate the first example of meta-C–H acylation via the mild carbonylation of arenes. This breakthrough reaction will open the way for the selective activation and carbonylation of meta-C(sp2)–H bonds and the efficient synthesis of hardly accessible organic compounds.
Objective
Carbonylative C-H activations can lead to an unprecedented degree of molecular sophistication by combining the atom-economical insertion of CO with the green activation of unreactive C-H bonds. In striking contrast to ortho C-H acylation of arenes and heteroarenes (directing-group strategy) and para C-H ones (Friedel-Crafts chemistry), meta C-H acylations are almost completely unexplored.
This proposal aims at the development of the first example of meta C-H acylation via mild carbonylation of arenes. Pivoting on this breakthrough, it will be possible to accomplish synthetic methods 1) for the efficient synthesis of hardly accessible organic compounds, 2) for the activation and carbonylation of meta C(sp2)-H bonds, 3) by employing transient directing group and 4) demonstrating the application of these protocols under continuous flow conditions.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2019
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
43121 PARMA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.