Obiettivo The DLK1-GTL2 domain is a recently discovered,evolutionary served,H 1 Mb cluster of imprinted genes mapping to 14q32 in man,distal 12 in the mouse and distal 18q in sheep.It tains at least four protein encoding genes expressed from the paternal allele (DLK1,RTL1,DIO3 and BEGAIN),as well as a series of non coding RNA genes expressed from the maternal allele (e.g. GTL2, MEG8, MIRG).It was recently demonstrated that the DLK1-GTL2 domain tains multiple small non coding RNA genes.More specifically,it includes (i) a pair of miRNA genes (miR-127 and miR-136) antisense to RTL1, (ii) a clusters of H C/D snoRNA genes thought to be processed from the introns of the non coding MEG8 gene,and (iii) a cluster of H 40 miRNA genes thought to be processed from a large precursor transcript referred to as MIRG. Elucidating the biological function and mode of action of the miRNA genes in the DLK1-GTL2 domain is the topic of this proposal.More precisely,the objectives of the Callimir proposal are:(i) to study the role of the miR-127 and miR-136 genes in development and in regulating the expression of the RTL1 gene and (ii) to study the role of the MIRG cluster of miRNA genes in development and in mediating the trans effect underlying polar overdominance. Campo scientifico natural sciencesbiological sciencesgeneticsmutationnatural sciencesbiological sciencesgeneticsRNAnatural sciencesbiological sciencesgeneticsgenomesnatural sciencescomputer and information sciencesinternetworld wide webnatural sciencesbiological sciencesmolecular biology Parole chiave callipyge imprinting micro RNA sno RNA Programma(i) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) LSH-2003-1.1.0-1 - Topics for Specific Targeted Research Project in the area of Fundamental knowledge and basic tools for functional genomics in all organisms Invito a presentare proposte FP6-2003-LIFESCIHEALTH-I Vedi altri progetti per questo bando Meccanismo di finanziamento STREP - Specific Targeted Research Project Coordinatore UNIVERSITÉ DE LIÈGE Contributo UE Nessun dato Indirizzo 7 place du XX aout LIÈGE Belgio Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (2) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Francia Contributo UE Nessun dato Indirizzo 3 rue Michel Ange PARIS Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITY OF CAMBRIDGE Regno Unito Contributo UE Nessun dato Indirizzo Cambridge CAMBRIDGE Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato
