Obiettivo The protein synthesis machinery represents one of the most useful targets for the development of new anti-infectives. Several families of broadly used antibiotics (tetracyclines, macrolides, and novel glycopeptides like vancomycin, among others) exert their function by blocking the protein synthesis machinery. Doxicycline, a tetracycline antibiotic, remains a useful tool for the prevention of paludism among travellers, despite its numerous secondary effects. And yet, very little is known about the specifics of the protein synthesis machinery in Plasmodium. A search of articles in the PubMed library with the words Plasmodium and ribosome/ribosomal in their titles will yield 6 publications since the year 2000. Only one article contains the words tRNA (or transfer RNA) and Plasmodium in its title, in the same period. And only one article in PubMed (Snewin et al., 1996) contains the words Plasmodium and ‘tRNA synthetase’ (or ligase) in its title. This lack of information about this central metabolic pathway in Plasmodium clearly blocks the possibility of transferring the knowledge in protein synthesis to the development of new anti-malarial drugs directed against the translational machinery of the parasite. Thus, the study of components of the genetic code in Plasmodium has the potential for providing new and important information on the biology of the parasite and, more importantly, open new leads for the development of novel anti-malarials. This proposal coordinates an effort to study tRNA biology in Plasmodium falciparum. It contains specific schemes for the development of new pharmacological screens, several initiatives for the selection of new potential anti-malarial drugs, and projects designed to answer fundamental questions regarding protein synthesis in Plasmodium. The laboratories in MEPHITIS accumulate a large body of experience in the biology of this parasite, and in different aspects of tRNA biology in model species. Campo scientifico medical and health scienceshealth sciencesinfectious diseasesmalariamedical and health scienceshealth sciencesparasitologymedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesclinical medicinepneumologytuberculosisnatural sciencesbiological sciencesgeneticsRNA Parole chiave Apicoplast Drug development Drug screening Elongation factors Malaria Plasmodium falciparum Protein synthesis aminoacyl-tRNA synthetases tRNA Programma(i) FP7-HEALTH - Specific Programme "Cooperation": Health Argomento(i) HEALTH-2007-2.3.2-12 - Highly innovative research in HIV/AIDS, malaria and tuberculosis between Indian and European partners Invito a presentare proposte FP7-HEALTH-2007-B Vedi altri progetti per questo bando Meccanismo di finanziamento CP-SICA - Collaborative project for specific cooperation actions dedicated to international cooperation partner countries (SICA) Coordinatore FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA) Contributo UE € 741 489,00 Indirizzo CARRER BALDIRI REIXAC 10-12 PARC SCIENTIFIC DE BARCELONA 08028 Barcelona Spagna Mostra sulla mappa Regione Este Cataluña Barcelona Tipo di attività Research Organisations Contatto amministrativo Adriana Grosu (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (7) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY Italia Contributo UE € 151 650,00 Indirizzo PADRICIANO 99 34149 Trieste Mostra sulla mappa Regione Nord-Est Friuli-Venezia Giulia Trieste Tipo di attività Research Organisations Contatto amministrativo Decio Ripandelli (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Francia Contributo UE € 269 530,00 Indirizzo RUE MICHEL ANGE 3 75794 Paris Mostra sulla mappa Regione Ile-de-France Ile-de-France Paris Tipo di attività Research Organisations Contatto amministrativo Philippe Pieri (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSIDADE DE AVEIRO Portogallo Contributo UE € 259 056,00 Indirizzo CAMPUS UNIVERSITÁRIO DE SANTIAGO 3810-193 Aveiro Mostra sulla mappa Regione Continente Centro (PT) Região de Aveiro Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Manuel António Da Silva Santos (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato FUNDACIO PARC CIENTIFIC DE BARCELONA Spagna Contributo UE € 329 256,00 Indirizzo BALDIRI I REIXAC 4 08028 Barcelona Mostra sulla mappa Regione Este Cataluña Barcelona Contatto amministrativo Miriam Royo Expósito (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITY OF MELBOURNE Australia Contributo UE Nessun dato Indirizzo PARKVILLEOFFICE OF THE VICE CHANCELLOR 3010 Melbourne Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Boland Alice (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ISTITUTO SUPERIORE DI SANITA Italia Contributo UE € 96 000,00 Indirizzo Viale Regina Elena 299 00161 Roma Mostra sulla mappa Regione Centro (IT) Lazio Roma Tipo di attività Research Organisations Contatto amministrativo Rosa Maria Martoccia (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH India Contributo UE € 298 170,00 Indirizzo Anusandhan Bhawan, Rafi Marg 2 110001 New Dehli Mostra sulla mappa Tipo di attività Research Organisations Contatto amministrativo Saman Habib (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato