Cel Understanding the properties of beneficial mutations is essential for a better understanding of adaptive evolution, since these mutations are the fuel of adaptation. Not only their individual fitness properties are important, but also their combined effect on fitness, which may deviate from the additive or multiplicative expectation that is often assumed in population genetic models. For instance, if the sign of the fitness effect of mutations (i.e. positive or negative) depends on the presence of other mutations, called sign epistasis, such interactions present an adaptive landscape with multiple fitness peaks, where the number of mutational pathways leading to higher fitness is constrained. Yet, empirical studies of beneficial mutations and their interactions are scarce, because beneficial mutations are rare and often inaccessible to experimental study, particularly the study of their interactions. Here, I propose to study the properties of beneficial mutations in experiments with the filamentous fungus Aspergillus nidulans. Using previously developed protocols to isolate beneficial mutations and to construct mutants with all possible combinations of beneficial mutations, we seek to study how selected mutations at the same (dominance) and different loci (epistasis) interact in determining fitness. The resulting data set will be one of the first presenting direct empirical information on the topography of the fitness landscape underlying adaptation. Dziedzina nauki natural sciencesphysical sciencesastronomyplanetary sciencesplanetary geologynatural sciencesbiological sciencesmicrobiologymycologynatural sciencesbiological sciencesgeneticsmutationengineering and technologyenvironmental engineeringenergy and fuels Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2009-IIF - Marie Curie Action: "International Incoming Fellowships" Zaproszenie do składania wniosków FP7-PEOPLE-2009-IIF Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IIF - International Incoming Fellowships (IIF) Koordynator WAGENINGEN UNIVERSITY Wkład UE € 169 535,20 Adres DROEVENDAALSESTEEG 4 6708 PB Wageningen Niderlandy Zobacz na mapie Region Oost-Nederland Gelderland Veluwe Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Oscar Van Rootselaar (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych