Obiettivo This project will develop methodology for the manufacture of novel peptide-based nanoparticles and nanocapsules to satisfy an unmet clinical need: sustained drug delivery to the posterior segment of the eye. The proposed consortium brings together internationally leading groups in self-assembling polypeptide nanoparticle and nanocapsule preparation by chemical (Durham) and genetic (Nijmegen) approaches, drug loading and in vitro release studies (Helsinki & Madrid), in vitro and in vivo assessment of nanoparticle biocompatibility and functionality (Helsinki, Madrid & Tübingen) and polymer synthesis, processing and industrial validation of manufacturing processes (DSM). Polyester micro- and nanoparticles that have been proposed for ocular drug delivery have several major drawbacks: acidic degradation products cause inflammation; drug release is difficult to control; and peptides and proteins are difficult to encapsulate. A platform of novel, peptide-based nanomaterials, formed through bio-inspired self-assembly processes, will be developed to overcome these problems. Peptide-based materials have a number of attractive features: biodegradation gives non-inflammatory products; self-assembly occurs under mild conditions; they possess a rich chemical diversity; they are defined at the sequence level. Polypeptides and peptide hybrid materials will be processed into nanoparticles, polymeric vesicles (polymersomes) and nanocapsules. These biodegradable and biocompatible materials will be used as containers for the loading, controlled release and cellular delivery of therapeutic molecules. The consortium therefore will enable the industrial manufacture of as-yet unobtainable, high value nanotechnology-based products utilising intrinisically low-energy demand nanobiotechnological phenomena. These will produce a step change improvement in the quality of products for sustained drug delivery to the posterior segment of the eye, enhancing the competitiveness of European industry. Campo scientifico engineering and technologymechanical engineeringmanufacturing engineeringnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural scienceschemical sciencespolymer sciencesengineering and technologynanotechnologynano-materials Programma(i) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Argomento(i) NMP-2009-1.1-1 - Nanobiotechnology: Applying life science principles as model for new nanotechnology-based mechanisms, processes, devices and/or systems Invito a presentare proposte FP7-NMP-2009-SMALL-3 Vedi altri progetti per questo bando Meccanismo di finanziamento CP-FP - Small or medium-scale focused research project Coordinatore UNIVERSITY OF DURHAM Contributo UE € 787 312,55 Indirizzo STOCKTON ROAD THE PALATINE CENTRE DH1 3LE Durham Regno Unito Mostra sulla mappa Regione North East (England) Tees Valley and Durham Durham CC Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Wendy Harle (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (5) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto STICHTING RADBOUD UNIVERSITEIT Paesi Bassi Contributo UE € 457 321,75 Indirizzo HOUTLAAN 4 6525 XZ Nijmegen Mostra sulla mappa Regione Oost-Nederland Gelderland Arnhem/Nijmegen Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Audri Lamers (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato DSM MATERIALS SCIENCE CENTER BV Paesi Bassi Contributo UE € 587 050,50 Indirizzo URMONDERBAAN 22 6167 RD Geleen Mostra sulla mappa Regione Zuid-Nederland Limburg (NL) Zuid-Limburg Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Willy Boekhout Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato HELSINGIN YLIOPISTO Finlandia Contributo UE € 566 547,20 Indirizzo YLIOPISTONKATU 3 00014 Helsingin Yliopisto Mostra sulla mappa Regione Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Sanna-Maija Miettinen (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSIDAD COMPLUTENSE DE MADRID Spagna Contributo UE € 759 368,00 Indirizzo AVENIDA DE SENECA 2 28040 Madrid Mostra sulla mappa Regione Comunidad de Madrid Comunidad de Madrid Madrid Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Maribel Rodríguez Villa (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato EBERHARD KARLS UNIVERSITAET TUEBINGEN Germania Contributo UE € 742 400,00 Indirizzo GESCHWISTER-SCHOLL-PLATZ 72074 Tuebingen Mostra sulla mappa Regione Baden-Württemberg Tübingen Tübingen, Landkreis Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Eberhart Zrenner (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
