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Non-invasive solution for periodontal and peri-implant diseases

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Ceramics prevent infection of dental implant through bacteriostatic action

Plaque build-up on teeth can lead to tooth decay as well as periodontal disease, one of the most prevalent form of bone pathology in humans. Through an innovative dental implant, the INPERIO project offers a solution for tackling plaque bacteria and maintaining healthy tooth implants.


Periodontal diseases, such as gingivitis and periodontitis, are infectious in nature and are caused by the formation of bacterial biofilms or dental plaque. Periodontitis associated bacteria destroy the attachments that surround and support teeth. They are also associated with other systemic conditions, including respiratory disease and various autoimmune disorders.

An innovative dental implant

When periodontal disease occurs in the presence of implants instead of natural teeth, it is even more aggressive, and it is called peri implantitis. With localised antimicrobial therapy failing, researchers of the EU-funded INPERIO project developed an innovative dental implant that combines breakthrough technologies. “Our goal was to provide a solution for patients suffering from peri-implantitis by combining patented biomaterials,” explains Lidia Goyos, INPERIO coordinator and project manager at Nanoker Research S.L. Researchers combined two patented technologies (property of the Spanish National Research Council, CSIC, and licensed in exclusivity to Nanoker Research S.L.) into a novel dental prosthetic product: a new ceramic composite and a new bioglass. This advanced composite ceramic material, which combines ceria-stabilized zirconia and alumina presents many advantages over existing ceramic dental solutions, including superior design functionalities. It also shows optimum surface roughness without the need to perform additional aggressive surface treatments to favour osseointegration. Moreover, its mechanical properties can withstand oral cavity forces long-term.

Clinical performance and future prospects

The INPERIO technology can produce narrow diameter implants, which are ideal for aesthetic restorations. The design of the implant also allows angle corrections, screw-retained restorations, and immediate load protocols. Additionally, it can be produced at any size to fit the patient’s needs. “The most significant aspect of the clinical behaviour of the INPERIO implant is that it follows the exact same surgical and prosthetic protocols as titanium implants, while providing the biological and antimicrobial advantages of ceramics,” emphasises Goyos. The bioglass coating prevents bacterial adhesion while allowing enhanced soft tissue attachment compared to standard titanium implants. By avoiding the formation of bacterial plaque, the implant guarantees the preservation of the patient's bone, which is the main cause of long term failure in conventional implants. The implant can be used at a wide range of disease stages, reducing the pain and treatment invasiveness. Importantly, its implementation is expected to cut down healthcare expenditure related to periodontal disease and peri-implantitis. It will also help reduce the consumption of antibiotics, as well as the emergence of antibiotic-resistant bacteria. According to Goyos, “the INPERIO scientific team was able to push their boundaries further than expected, which has resulted in a game changing product that we hope will have a very positive impact on the health of patients suffering from periodontal and peri-implant disease around the world.” The team is currently working on a new product, a two-piece all-ceramic dental implant with the versatility of the most advanced two-piece titanium dental implants. In addition, they are undertaking all the necessary certification actions to get the bioglass coating to the market as soon as possible, and include it on the proprietary products of Nanoker Research S.L.


INPERIO, dental implant, ceramic, peri-implantitis, bioglass, periodontitis

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