Trans-disciplinary epigenetics research
Understanding human disease often means facing complex challenges that require a holistic approach to problem-solving. Inter- and trans disciplinary research is essential in meeting these challenges, as it brings together different perspectives and expertise to tackle complex scientific problems and communicate the results effectively.
A training network in epigenetics research
Undertaken with the support of the Marie Skłodowska-Curie Actions programme, the ChromDesign project set out to investigate the impact of 3D chromatin organisation on gene regulation in normal and pathologic states and to further understand human disease. The ChromDesign Innovative Training Network involved 11 European academic and private institutions and 6 partner organisations, bringing together experts in the field of chromatin biology to train and empower early-stage researchers in state of the art epigenetics research. “The ChromDesign network is a prime example of how trans disciplinary research can drive innovation and progress in the field of chromatin architecture and design,” outlines Luciano Di Croce, the coordinator of the ChromDesign network. Using several state-of-the-art technologies such as genomics, imaging, cell biology, and computational modelling, researchers provided important knowledge on chromatin architecture and dynamics as well as on epigenetic mechanisms of leukaemia. Moreover, ChromDesign optimised experimental protocols for the investigation of chromatin architecture.
A trans-disciplinary approach to epigenetics research
ChromDesign employed a trans-disciplinary approach using methodologies of research design and technology. Collectively, the acquired knowledge will contribute to the identification of novel targets that can be exploited for the diagnosis and treatment of human pathologies, positively impacting patients’ lives. “In ChromDesign, we are convinced that these trans-disciplinary approaches are very beneficial not only for the training of researchers but to the future of science, driving innovation, and providing valuable skills to everyone involved in the network. We will continue to support trans-disciplinarity in the field of epigenetics to nurture excellence in research,” emphasises the scientific project manager of the network, David Brena.
Communicating results to the general public
The need of communicating the scientific results to a broader audience inspired ChromDesign to develop a communication toolkit. This facilitated the process of sharing complex scientific concepts with society and had a very positive impact on the communication skills of all the researchers involved in the network. The network organised the science-inspired exhibition and experience ‘Life’s Journey, The Blocks That Build Us All’. The exhibition offered visitors the opportunity to take a journey through DNA, from its basic units to its 3D structure up close, embodied by a 2 metre interactive technology structure, representing the spatial structure of the DNA. Visitors also created their own DNA sequences, edited them, and corrected mutations that would produce a genetic disease, which is ultimately the goal of many researchers working in the field. Finally, the exhibition also highlighted the important contributions of the research done within the ChromDesign network, bringing forward the exciting and growing field of chromatin architecture. The exhibition was presented to a wide audience in the design school ELISAVA, the research hub PRBB in Barcelona, and the ‘Science is Wonderful!’ event in Brussels. Overall, the intersection between science, communication and design was one of the key strengths of the ChromDesign network and allowed the communication of their results to nearly 9 000 people of various backgrounds.
Keywords
ChromDesign, chromatin, epigenetics, chromatin architecture, communication, trans disciplinary research, training network, gene regulation, leukaemia