Marine Biodiversity as Sustainable Resource of Disease-Suppressive Microbes and Bioprotectants for Aquaculture and Crop Diseases

Project Information

MARBLES

Grant agreement ID: 101000392

DOI

10.3030/101000392

EC signature date 21 April 2021

Start date 1 May 2021

End date 30 April 2026

Funded under

• SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy

Total cost

€ 7 496 896,25

EU contribution

€ 7 496 896,25

Coordinated by

UNIVERSITEIT LEIDEN
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Other (1)

Portfolio of Promotional Material

Publications

Peer reviewed articles (15)

antiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation

Author(s): Kai Blin, Simon Shaw, Lisa Vader, Judit Szenei, Zachary L Reitz, Hannah E Augustijn, José D D Cediel-Becerra, Valérie de Crécy-Lagard, Robert A Koetsier, Sam E Williams, Pablo Cruz-Morales, Sopida Wongwas, Alejandro E Segurado Luchsinger, Friederike Biermann, Aleksandra Korenskaia, Mitja M Zdouc, David Meijer, Barbara R Terlouw, Justin J J van der Hooft, Nadine Ziemert, Eric J N H
Published in: Nucleic Acids Research, 2025, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaf334

Novel types of RiPP-modifying enzymes

Author(s): Richter, D., & Piel, J.
Published in: Current Opinion in Chemical Biology, Issue 80, 102463, 2024, ISSN 1367-5931
Publisher: Elsevier BV
DOI: 10.1016/j.cbpa.2024.102463

Marine microbial enzymes as potential antibiofilm agents: expanding the arsenal of bioactive agents targeting biofilm-forming microorganisms

Author(s): Anna Luiza Bauer Canellas, Gabriel Rodrigues Dias, Isabelle Rodrigues Lopes, Jéssyca Freitas-Silva, Alan D. W. Dobson, Marinella Silva Laport, Bruno Francesco Rodrigues de Oliveira
Published in: Critical Reviews in Microbiology, 2025, Page(s) 1-18, ISSN 1040-841X
Publisher: Taylor & Francis
DOI: 10.1080/1040841x.2025.2510247

Stronger together: harnessing natural algal communities as potential probiotics for inhibition of aquaculture pathogens

Author(s): Dóra Smahajcsik, Line Roager, Mikael Lenz Strube, Sheng-Da Zhang, Lone Gram
Published in: Microbiology Spectrum, 2025, ISSN 2165-0497
Publisher: American Society for Microbiology
DOI: 10.1128/spectrum.00421-25

Comparative Metagenomic Analysis of Biosynthetic Diversity across Sponge Microbiomes Highlights Metabolic Novelty, Conservation, and Diversification

Author(s): Loureiro, C., Galani, A., Gavriilidou, A., Chaib de Mares, M., van der Oost, J., Medema, M. H., & Sipkema, D.
Published in: MSystems, Issue 00219193, 2022, ISSN 0021-9193
Publisher: American Society for Microbiology
DOI: 10.1128/msystems.00357-22

Biosynthetic potential of the global ocean microbiome

Author(s): Paoli, L., Ruscheweyh, H. J., Forneris, C. C., Hubrich, F., Kautsar, S., Bhushan, A., Lotti, A., Clayssen, Q., Salazar, G., Milanese, A., Carlström, C. I., Papadopoulou, C., Gehrig, D., Karasikov, M., Mustafa, H., Larralde, M., Carroll, L. M., Sánchez, P., Zayed, A. A., Cronin, D.R., Acinas, S.G., Bork, P., Bowler, C., Delmont, T.O., Gasol, J.M., Gossert, A.D., Kahles, A., Sullivan, M.B., Wincke
Published in: Nature, Issue 607, 2022, Page(s) 111–118, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04862-3

From friends to foes: fungi could be emerging marine sponge pathogens under global change scenarios

Author(s): Pérez-Llano Y, Yarzábal Rodríguez LA, Martínez-Romero E, Dobson ADW, Gunde-Cimerman N, Vasconcelos V and Batista-García RA.
Published in: Frontiers in Microbiology, Issue 14:1213340, 2023, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2023.1213340

Non-targeted metabolomics-based molecular networking enables the chemical characterization of Rumex sanguineus, a wild edible plant

Author(s): Valentina Ramundi, Mitja M. Zdouc, Enrica Donati, Justin J. J. van der Hooft, Sara Cimini, Laura Righetti
Published in: Metabolomics, Issue 21, 2025, ISSN 1573-3890
Publisher: Springer Science+Business Media
DOI: 10.1007/s11306-024-02210-2

Metabolome-guided genome mining of RiPP natural products.

Author(s): Zdouc, M. M., van der Hooft, J.J.J. and Medema, M.H.
Published in: Trends in Pharmacological Sciences, 2023, ISSN 0165-6147
Publisher: Elsevier BV
DOI: 10.1016/j.tips.2023.06.004

MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters.

Author(s): Barbara R Terlouw 1 , Kai Blin 2 , Jorge C Navarro-Muñoz 1 3 , Nicole E Avalon 4 , Marc G Chevrette 5 , Susan Egbert 6 , Sanghoon Lee 7 , David Meijer 1 , Michael J J Recchia 7 , Zachary L Reitz 1 , Jeffrey A van Santen 7 8 , Nelly Selem-Mojica 9 , Thomas Tørring 10 , Liana Zaroubi 7 , Mohammad Alanjary 1 , Gajender Aleti 11 , César Aguilar 12 , Suhad A A A
Published in: Nucleic Acids Research, Issue 51 (D1), 2022, Page(s) D603–D610, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkac1049

Unpacking policy developments in marine natural product research: a scientist's guide to DSI and BBNJ

Author(s): Federica Casolari, Amelia Westmoreland, Thomas Vanagt, Marcel Jaspars
Published in: Natural Product Reports, 2025, ISSN 0265-0568
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4np00070f

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

Author(s): Mitja M Zdouc, Kai Blin, Nico L L Louwen, Jorge Navarro, Catarina Loureiro, Chantal D Bader, Constance B Bailey, Lena Barra, Thomas J Booth, Kenan A J Bozhüyük, José D D Cediel-Becerra, Zachary Charlop-Powers, Marc G Chevrette, Yit Heng Chooi, Paul M D’Agostino, Tristan de Rond, Elena Del Pup, Katherine R Duncan, Wenjia Gu, Novriyandi Hanif, Eric J N Helfrich, Matthew Jenner, Yoh
Published in: Nucleic Acids Research, Issue 53, 2025, Page(s) D678-D690, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkae1115

Integrated Omics-Based Discovery of Bioactive Halogenated Metabolites from the Deep-Sea Streptomyces sp. B188M101

Author(s): Emmanuel Tope Oluwabusola, Stephen A. Jackson, Cristina Brunati, Stefanie Gackstatter, Hannah Vedder, Marianna Iorio, Gargee Chawande, Lekha Menon Margassery, Giang-Son Nguyen, David J. Clarke, Rainer Ebel, Marcel Jaspars, Alan D. W. Dobson
Published in: Marine Drugs, Issue 23, 2025, Page(s) 362, ISSN 1660-3397
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md23090362

Olive mill solid waste induces beneficial mushroom-specialized metabolite diversity revealed by computational metabolomics strategies

Author(s): Soliman Khatib, Idan Pereman, Elizabeth Kostanda, Mitja M. Zdouc, Nirit Ezov, Ron Schweitzer, Justin J. J. van der Hooft
Published in: Metabolomics, Issue 21, 2025, ISSN 1573-3890
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s11306-025-02257-9

Improving the odds: Artificial intelligence and the great plate count anomaly

Author(s): Detmer Sipkema
Published in: Microbial Biotechnology, Issue 17, 2024, ISSN 1751-7915
Publisher: Wiley
DOI: 10.1111/1751-7915.70004

Non-peer reviewed articles (2)

FERMO: a Dashboard for Streamlined Rationalized Prioritization of Molecular Features from Mass Spectrometry Data.

Author(s): Zdouc, M. M., Bayona Maldonado, L. M., Augustijn, H. E., Soldatou, S., de Jonge, N., Jaspars, M., van Wezel, G. P., Medema, M. H., & van der Hooft, J. J. J.
Published in: BioRxiv, 2022, ISSN 2692-8205
Publisher: xx
DOI: 10.1101/2022.12.21.521422

The Minimum Information about a Tailoring Enzyme/Maturase data standard for capturing natural product biosynthesis

Author(s): Zdouc, M. M., Meijer, D., Biermann, F., Holme, J., Korenskaia, A., Lien, A., Louwen, N. L. L., Navarro-Muñoz, J. C., Nguyen, G., Rutz, A., Sveshnikova, A., Szenei, J., Terlouw, B., Ortega, R. T., Feuermann, M., Bridge, A. J., Van Der Hooft, J. J. J., Weber, T., Ziemert, N., . . . Medema, M. H.
Published in: Biological and Medicinal Chemistry, 2024, ISSN 2573-2293
Publisher: ChemRxiv
DOI: 10.26434/chemrxiv-2024-78mtl

Other (1)

Disclosing and Sharing Genetic Resources: Recommendations based on the WIPO Treaty and BBNJ Agreement

Author(s): Abbe E. l. Brown
Published in: 2024
Publisher: n/a

Monographic books (1)

Decoding Marine Genetic Resource Governance Under the BBNJ Agreement

Author(s): F. Humphries (Ed.)
Published in: Sustainable Development Goals Series, 2025
Publisher: Springer Nature Switzerland
DOI: 10.1007/978-3-031-72100-7