Marine Biodiversity as Sustainable Resource of Disease-Suppressive Microbes and Bioprotectants for Aquaculture and Crop Diseases

Informazioni relative al progetto

MARBLES

ID dell’accordo di sovvenzione: 101000392

DOI

10.3030/101000392

Progetto chiuso

Data della firma CE 21 Aprile 2021

Data di avvio 1 Maggio 2021

Data di completamento 30 Aprile 2026

Finanziato da

• SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy

Costo totale

€ 7 496 896,25

Contributo UE

€ 7 496 896,25

Coordinato da

UNIVERSITEIT LEIDEN
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Other (1)

Portfolio of Promotional Material

Pubblicazioni

Peer reviewed articles (22)

Chemical richness and diversity of uncultivated ‘Entotheonella’ symbionts in marine sponges

Autori: Maria Dell, Masato Kogawa, Alena B. Streiff, Taro Shiraishi, Alessandro Lotti, Christoph M. Meier, Michelle A. Schorn, Christopher Field, Jackson K. B. Cahn, Hiromi Yokoyama, Yuito Yamada, Eike Peters, Yoko Egami, Yu Nakashima, Karen Co Tan, Christian Rückert, Mohammad Alanjary, Jörn Kalinowski, Tomohisa Kuzuyama, Paco Cardenas, Shirley Pomponi, Detmer Sipkema, Amy Wright, Kentaro Takada, Ikuro
Pubblicato in: Nature Chemical Biology, Numero 22, 2026, Pagina/e 217-228, ISSN 1552-4450
Editore: Nature Publishing Group
DOI: 10.1038/s41589-025-02066-0

antiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation

Autori: Kai Blin, Simon Shaw, Lisa Vader, Judit Szenei, Zachary L Reitz, Hannah E Augustijn, José D D Cediel-Becerra, Valérie de Crécy-Lagard, Robert A Koetsier, Sam E Williams, Pablo Cruz-Morales, Sopida Wongwas, Alejandro E Segurado Luchsinger, Friederike Biermann, Aleksandra Korenskaia, Mitja M Zdouc, David Meijer, Barbara R Terlouw, Justin J J van der Hooft, Nadine Ziemert, Eric J N H
Pubblicato in: Nucleic Acids Research, 2025, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkaf334

Novel types of RiPP-modifying enzymes

Autori: Richter, D., & Piel, J.
Pubblicato in: Current Opinion in Chemical Biology, Numero 80, 102463, 2024, ISSN 1367-5931
Editore: Elsevier BV
DOI: 10.1016/j.cbpa.2024.102463

An actionable guide to the United Nations' Biodiversity Beyond National Jurisdiction Agreement for research scientists

Autori: Jeffrey Marlow, Arianna Broggiato, Janine Felson, Harriet Harden‐Davies, Rebecca Helm, Marcel Jaspars
Pubblicato in: Limnology and Oceanography, Numero 71, 2026, Pagina/e (1), ISSN 0024-3590
Editore: American Society of Limnonogy and Oceanography
DOI: 10.1002/lno.70274

New insights into the microbiome of the deep-sea sponge Inflatella pellicula and the secondary metabolic potential of metagenome-assembled genomes and the wider microbiome

Autori: Stephen A. Jackson, Pavlo Hrab, Mitja M. Zdouc, David J. Clarke, Alan D.W. Dobson
Pubblicato in: Microbial Genomics, Numero 12, 2026, Pagina/e (1), ISSN 2057-5858
Editore: Microbiology Society
DOI: 10.1099/mgen.0.001602

Marine microbial enzymes as potential antibiofilm agents: expanding the arsenal of bioactive agents targeting biofilm-forming microorganisms

Autori: Anna Luiza Bauer Canellas, Gabriel Rodrigues Dias, Isabelle Rodrigues Lopes, Jéssyca Freitas-Silva, Alan D. W. Dobson, Marinella Silva Laport, Bruno Francesco Rodrigues de Oliveira
Pubblicato in: Critical Reviews in Microbiology, 2025, Pagina/e 1-18, ISSN 1040-841X
Editore: Taylor & Francis
DOI: 10.1080/1040841x.2025.2510247

Desferrioxamine Sharing among Microalgae-Associated Bacteria Enhances Iron-Limited Inhibition of <i>Vibrio anguillarum</i>

Autori: Dóra Smahajcsik, Mille Rask Sander, Matilde Emídio Almeida, Patricia Arias-Orozco, Jette Melchiorsen, Daniel J. Otto, Lone Gram, Scott A. Jarmusch
Pubblicato in: Journal of Natural Products, Numero 89, 2026, Pagina/e 955-965, ISSN 0163-3864
Editore: American Chemical Society
DOI: 10.1021/acs.jnatprod.5c01565

Stronger together: harnessing natural algal communities as potential probiotics for inhibition of aquaculture pathogens

Autori: Dóra Smahajcsik, Line Roager, Mikael Lenz Strube, Sheng-Da Zhang, Lone Gram
Pubblicato in: Microbiology Spectrum, 2025, ISSN 2165-0497
Editore: American Society for Microbiology
DOI: 10.1128/spectrum.00421-25

Probiotic potential of Isochrysis galbana microbiomes against the fish pathogen Vibrio anguillarum

Autori: Matilde Emídio Almeida, Dóra Smahajcsik, Shengda Zhang, Lone Gram
Pubblicato in: Aquaculture, Numero 612, 2025, Pagina/e 743196, ISSN 0044-8486
Editore: Elsevier BV
DOI: 10.1016/j.aquaculture.2025.743196

Comparative Metagenomic Analysis of Biosynthetic Diversity across Sponge Microbiomes Highlights Metabolic Novelty, Conservation, and Diversification

Autori: Loureiro, C., Galani, A., Gavriilidou, A., Chaib de Mares, M., van der Oost, J., Medema, M. H., & Sipkema, D.
Pubblicato in: MSystems, Numero 00219193, 2022, ISSN 0021-9193
Editore: American Society for Microbiology
DOI: 10.1128/msystems.00357-22

Correction: Unpacking policy developments in marine natural product research: a scientist's guide to DSI and BBNJ

Autori: Federica Casolari, Amelia Westmoreland, Thomas Vanagt, Marcel Jaspars
Pubblicato in: Natural Product Reports, Numero 42, 2025, Pagina/e 1909-1909, ISSN 0265-0568
Editore: Royal Society of Chemistry
DOI: 10.1039/d5np90039e

Biosynthetic potential of the global ocean microbiome

Autori: Paoli, L., Ruscheweyh, H. J., Forneris, C. C., Hubrich, F., Kautsar, S., Bhushan, A., Lotti, A., Clayssen, Q., Salazar, G., Milanese, A., Carlström, C. I., Papadopoulou, C., Gehrig, D., Karasikov, M., Mustafa, H., Larralde, M., Carroll, L. M., Sánchez, P., Zayed, A. A., Cronin, D.R., Acinas, S.G., Bork, P., Bowler, C., Delmont, T.O., Gasol, J.M., Gossert, A.D., Kahles, A., Sullivan, M.B., Wincke
Pubblicato in: Nature, Numero 607, 2022, Pagina/e 111–118, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-022-04862-3

From friends to foes: fungi could be emerging marine sponge pathogens under global change scenarios

Autori: Pérez-Llano Y, Yarzábal Rodríguez LA, Martínez-Romero E, Dobson ADW, Gunde-Cimerman N, Vasconcelos V and Batista-García RA.
Pubblicato in: Frontiers in Microbiology, Numero 14:1213340, 2023, ISSN 1664-302X
Editore: Frontiers Media
DOI: 10.3389/fmicb.2023.1213340

Non-targeted metabolomics-based molecular networking enables the chemical characterization of Rumex sanguineus, a wild edible plant

Autori: Valentina Ramundi, Mitja M. Zdouc, Enrica Donati, Justin J. J. van der Hooft, Sara Cimini, Laura Righetti
Pubblicato in: Metabolomics, Numero 21, 2025, ISSN 1573-3890
Editore: Springer Science+Business Media
DOI: 10.1007/s11306-024-02210-2

Host Evolutionary History Drives Prokaryotic Diversity in the Globally Distributed Sponge Family Petrosiidae

Autori: N. van der Windt, B. Paix, J. C. Biesmeijer, R. Ambo‐Rappe, Y. M. Huang, K. G. S. Nirbadha, D. Sipkema, N. J. de Voogd
Pubblicato in: Molecular Ecology, 2025, ISSN 0962-1083
Editore: Blackwell Publishing Inc.
DOI: 10.1111/mec.70186

Metabolome-guided genome mining of RiPP natural products.

Autori: Zdouc, M. M., van der Hooft, J.J.J. and Medema, M.H.
Pubblicato in: Trends in Pharmacological Sciences, 2023, ISSN 0165-6147
Editore: Elsevier BV
DOI: 10.1016/j.tips.2023.06.004

MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters.

Autori: Barbara R Terlouw 1 , Kai Blin 2 , Jorge C Navarro-Muñoz 1 3 , Nicole E Avalon 4 , Marc G Chevrette 5 , Susan Egbert 6 , Sanghoon Lee 7 , David Meijer 1 , Michael J J Recchia 7 , Zachary L Reitz 1 , Jeffrey A van Santen 7 8 , Nelly Selem-Mojica 9 , Thomas Tørring 10 , Liana Zaroubi 7 , Mohammad Alanjary 1 , Gajender Aleti 11 , César Aguilar 12 , Suhad A A A
Pubblicato in: Nucleic Acids Research, Numero 51 (D1), 2022, Pagina/e D603–D610, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkac1049

Unpacking policy developments in marine natural product research: a scientist's guide to DSI and BBNJ

Autori: Federica Casolari, Amelia Westmoreland, Thomas Vanagt, Marcel Jaspars
Pubblicato in: Natural Product Reports, 2025, ISSN 0265-0568
Editore: Royal Society of Chemistry
DOI: 10.1039/d4np00070f

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

Autori: Mitja M Zdouc, Kai Blin, Nico L L Louwen, Jorge Navarro, Catarina Loureiro, Chantal D Bader, Constance B Bailey, Lena Barra, Thomas J Booth, Kenan A J Bozhüyük, José D D Cediel-Becerra, Zachary Charlop-Powers, Marc G Chevrette, Yit Heng Chooi, Paul M D’Agostino, Tristan de Rond, Elena Del Pup, Katherine R Duncan, Wenjia Gu, Novriyandi Hanif, Eric J N Helfrich, Matthew Jenner, Yoh
Pubblicato in: Nucleic Acids Research, Numero 53, 2025, Pagina/e D678-D690, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkae1115

Integrated Omics-Based Discovery of Bioactive Halogenated Metabolites from the Deep-Sea Streptomyces sp. B188M101

Autori: Emmanuel Tope Oluwabusola, Stephen A. Jackson, Cristina Brunati, Stefanie Gackstatter, Hannah Vedder, Marianna Iorio, Gargee Chawande, Lekha Menon Margassery, Giang-Son Nguyen, David J. Clarke, Rainer Ebel, Marcel Jaspars, Alan D. W. Dobson
Pubblicato in: Marine Drugs, Numero 23, 2025, Pagina/e 362, ISSN 1660-3397
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md23090362

Olive mill solid waste induces beneficial mushroom-specialized metabolite diversity revealed by computational metabolomics strategies

Autori: Soliman Khatib, Idan Pereman, Elizabeth Kostanda, Mitja M. Zdouc, Nirit Ezov, Ron Schweitzer, Justin J. J. van der Hooft
Pubblicato in: Metabolomics, Numero 21, 2025, ISSN 1573-3890
Editore: Springer Science and Business Media LLC
DOI: 10.1007/s11306-025-02257-9

Improving the odds: Artificial intelligence and the great plate count anomaly

Autori: Detmer Sipkema
Pubblicato in: Microbial Biotechnology, Numero 17, 2024, ISSN 1751-7915
Editore: Wiley
DOI: 10.1111/1751-7915.70004

Non-peer reviewed articles (2)

FERMO: a Dashboard for Streamlined Rationalized Prioritization of Molecular Features from Mass Spectrometry Data.

Autori: Zdouc, M. M., Bayona Maldonado, L. M., Augustijn, H. E., Soldatou, S., de Jonge, N., Jaspars, M., van Wezel, G. P., Medema, M. H., & van der Hooft, J. J. J.
Pubblicato in: BioRxiv, 2022, ISSN 2692-8205
Editore: xx
DOI: 10.1101/2022.12.21.521422

The Minimum Information about a Tailoring Enzyme/Maturase data standard for capturing natural product biosynthesis

Autori: Zdouc, M. M., Meijer, D., Biermann, F., Holme, J., Korenskaia, A., Lien, A., Louwen, N. L. L., Navarro-Muñoz, J. C., Nguyen, G., Rutz, A., Sveshnikova, A., Szenei, J., Terlouw, B., Ortega, R. T., Feuermann, M., Bridge, A. J., Van Der Hooft, J. J. J., Weber, T., Ziemert, N., . . . Medema, M. H.
Pubblicato in: Biological and Medicinal Chemistry, 2024, ISSN 2573-2293
Editore: ChemRxiv
DOI: 10.26434/chemrxiv-2024-78mtl

Other (1)

Disclosing and Sharing Genetic Resources: Recommendations based on the WIPO Treaty and BBNJ Agreement

Autori: Abbe E. l. Brown
Pubblicato in: 2024
Editore: n/a

Monographic books (1)

Decoding Marine Genetic Resource Governance Under the BBNJ Agreement

Autori: F. Humphries (Ed.)
Pubblicato in: Sustainable Development Goals Series, 2025
Editore: Springer Nature Switzerland
DOI: 10.1007/978-3-031-72100-7