Projektbeschreibung
Innovatives Mikroskop für die Zellsortierung
REVEAL ist ein EU-finanziertes multidisziplinäres Projekt, das eine revolutionäre Mikroskopietechnik für die Bildgebung lebender Zellen im 2D- und 3D-Format entwickelt. Unterstützt durch maschinelle Lernalgorithmen erkennt und interpretiert das Mikroskop zelluläre Ereignisse, die mögliche Ursachen für eine maligne Transformation sein können. Es soll die Identifizierung und Auswahl verschiedener Arten von Leberzellen ermöglichen, die dann auf molekularer und biochemischer Ebene analysiert werden können. Das Projekt wird unter dem Mikroskop identifizierte zelluläre Phänotypen mit Genexpressionsprofilen korrelieren und damit wichtige Erkenntnisse zu zellulären Auslösern von Leberkrebs liefern.
Ziel
The REVEAL project aims at installing a novel microscope at the interface of instrumentation, machine learning and Biology. This new microscopy technique will rely heavily on neural networks to be able to perceive, interpret, conjecture, infer, anticipate and act. The present project intends to lay down the foundations of this ‘neuronal microscopy’ in the realms of 2D and 3D cell live imaging.
To achieve this goal, we will develop the necessary tools and the first instruments that will demonstrate the feasibility and the power of this new microscopy framework. In particular, we will develop a ‘cell picking neuronal microscope’ that will allow us to detect and collect different subtype of liver cells that are due to become tumoral and analyse them ahead of tumour manifestation. This analysis will help us to characterize the cellular heterogeneity known to exist at the origin of liver cancer. It will provide a direct mapping between cellular phenotypes observed under microscope and gene expression present in the early stages of liver cancer. Overall, we are thus defining a novel methodology, giving a central place to neuronal microscopy in the understanding of the cellular origin of the diseases.
REVEAL is a multidisciplinary project engaging 7 EU partners (2 being SMEs) from 4 countries covering the RTO, academic and industrial worlds, including medical doctors. An implementation plan is presented in the form of 6 work packages, 4 of them being technical. Synergy in communication and dissemination by the several partners and stakeholders will permit to maximize the project impact. Solutions to overcome the technological barriers, as well as appropriate deliverables, tasks, milestones and risks are presented, in order to complete the project objectives in due time . The REVEAL project outcomes are fully in line with the H2020 ICT-36-2020 call, subtopic iv, as it will develop novel methods and devices as research tools to understand the cellular origin of diseases.
Wissenschaftliches Gebiet
Schlüsselbegriffe
Programm/Programme
Thema/Themen
Aufforderung zur Vorschlagseinreichung
Andere Projekte für diesen Aufruf anzeigenUnterauftrag
H2020-ICT-2020-2
Finanzierungsplan
RIA - Research and Innovation actionKoordinator
75015 PARIS 15
Frankreich