Molecular choreography of bacterial chemotaxis signalling

Project Information

ChemoTaxi

Grant agreement ID: 101021133

DOI

10.3030/101021133

EC signature date 22 June 2021

Start date 1 September 2021

End date 31 August 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 781 133,00

EU contribution

€ 1 781 133,00

Coordinated by

DIAMOND LIGHT SOURCE LIMITED
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (26)

Neutral sphingomyelinase 2 is required for HIV-1 maturation

Author(s): Abdul A Waheed 1 , Yanan Zhu 2 , Eva Agostino 1 , Lwar Naing 1 , Yuta Hikichi 1 , Ferri Soheilian 3 , Seung-Wan Yoo 4 , Yun Song 5 , Peijun Zhang 2 5 6 , Barbara S Slusher 4 7 8 , Norman J Haughey 4 8 , Eric O Freed 1
Published in: PNAS, 2023, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2219475120

Structure of the native chemotaxis core signaling unit from phage E-protein lysed E. coli cells

Author(s): "C Keith Cassidy # 1 2 , Zhuan Qin # 3 , Thomas Frosio 1 , Khoosheh Gosink 4 , Zhengyi Yang 1 , Mark S P Sansom 5 , Phillip J Stansfeld 6 , John S Parkinson 4 , Peijun Zhang"
Published in: mBio, 2023, ISSN 2150-7511
Publisher: ASM
DOI: 10.1128/mbio.00793-23

A structural view of the SARS-CoV-2 virus and its assembly

Author(s): Hardenbrook N and Zhang P
Published in: Current Opinion in Virology, 2022, ISSN 1879-6265
Publisher: Elsevier
DOI: 10.1016/j.coviro.2021.11.011

Cryogenic electron ptychographic single particle analysis with wide bandwidth information transfer

Author(s): Xudong Pei; Liqi Zhou; Chen Huang; Mark Boyce; Judy S. Kim; Emanuela Liberti; Yiming Hu; Takeo Sasaki; Peter D. Nellist; Peijun Zhang; David I. Stuart; Angus I. Kirkland; Peng Wang
Published in: Nature Communications, Issue 1, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-38268-0

CryoEM structure of the super-constricted two-start dynamin 1 filament

Author(s): Liu J, Alvarez FJD, Clare DK, Noel JK, Zhang P
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-25741-x

ChAdOx1 COVID vaccines express RBD open prefusion SARS-CoV-2 spikes on the cell surface

Author(s): Tao Ni,1,7,9 Luiza Mendonça,1,8,9 Yanan Zhu,1,9 Andrew Howe,2 Julika Radecke,2 Pranav M. Shah,1,3 Yuewen Sheng,2 Anna-Sophia Krebs,1 Helen M.E. Duyvesteyn,1 Elizabeth Allen,4 Teresa Lambe,4,5 Cameron Bisset,4 Alexandra Spencer,4 Susan Morris,6 David I. Stuart,1,2,3,6 Sarah Gilbert,4,5,6 and Peijun Zhang1,2,3,10,∗
Published in: iScience, 2023, ISSN 2589-0042
Publisher: Elsevier Inc
DOI: 10.1016/j.isci.2023.107882

IceBreaker: Software for high-resolution single-particle cryo-EM with non-uniform ice

Author(s): Olek M, Cowtan K, Webb D, Chaban Y, Zhang P
Published in: Structure, 2022, ISSN 0969-2126
Publisher: Cell Press
DOI: 10.1016/j.str.2022.01.005

The Effect of Inositol Hexakisphosphate on HIV-1 Particle Production and Infectivity can be Modulated by Mutations that Affect the Stability of the Immature Gag Lattice

Author(s): Alex B Kleinpeter 1 , Yanan Zhu 2 , Donna L Mallery 3 , Sherimay D Ablan 4 , Long Chen 2 , Nathan Hardenbrook 2 , Adolfo Saiardi 5 , Leo C James 6 , Peijun Zhang 7 , Eric O Freed 8
Published in: Journal of Molecular Biology, 2023, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2023.168037

Mechanisms of E. coli chemotaxis signaling pathways visualized using cryoET and computational approaches

Author(s): Hadjidemetriou K, Kaur S, Cassidy CK, Zhang P
Published in: Biochem Soc Trans, 2022, ISSN 1470-8752
Publisher: Biochemical Society
DOI: 10.1042/bst20220191

The molecular basis of regulation of bacterial capsule assembly by Wzc

Author(s): Yang Y, Liu J, Clarke BR, Seidel L, Bolla JR, Ward PN, Zhang P, Robinson CV, Whitfield C, Naismith JH
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24652-1

Structure of native chromatin fibres revealed by Cryo-ET in situ

Author(s): Zhen Hou, Frank Nightingale, Yanan Zhu, Craig MacGregor-Chatwin & Peijun Zhang
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-42072-1

Probing the biogenesis pathway and dynamics of thylakoid membranes

Author(s): Huokko T, Ni T, Dykes GF, Simpson DM, Brownridge P, Conradi FD, Beynon RJ, Nixon PJ, Mullineaux CW, Zhang P, Liu LN
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-23680-1

Studying bacterial chemosensory array with CryoEM

Author(s): Qin Z, Zhang P
Published in: Biochem Soc Trans, 2021, ISSN 1470-8752
Publisher: Portland Press
DOI: 10.1042/bst20210080

Structure and assembly of cargo Rubisco in two native α-carboxysomes

Author(s): Ni T, Sun Y, Burn W, Al-Hazeem MMJ, Zhu Y, Yu X, Liu LN, Zhang P
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32004-w

Cryo-electron tomography to study viral infection

Author(s): Miles Graham and Peijun Zhang
Published in: Biochem Soc Trans, 2023, ISSN 0300-5127
Publisher: Portland Press, Ltd.
DOI: 10.1042/bst20230103

Cryo-electron Tomography Remote Data Collection and Subtomogram Averaging

Author(s): Sheng Y, Morris K, Radecke J, Zhang P
Published in: JoVE, 2022, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/63923

Correlative multi-scale cryo-imaging unveils SARS-CoV-2 assembly and egress

Author(s): Mendonça L, Howe A, Gilchrist JB, Sheng Y, Sun D, Knight ML, Zanetti-Domingues LC, Bateman B, Krebs AS, Chen L, Radecke J, Li VD, Ni T, Kounatidis I, Koronfel MA, Szynkiewicz M, Harkiolaki M, Martin-Fernandez ML, James W, Zhang P
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24887-y

Structure and activity of particulate methane monooxygenase arrays in methanotrophs

Author(s): Zhu Y, Koo CW, Cassidy CK, Spink MC, Ni T, Zanetti-Domingues LC, Bateman B, Martin-Fernandez ML, Shen J, Sheng Y, Song Y, Yang Z, Rosenzweig AC, Zhang P
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32752-9

Structure of native HIV-1 cores and their interactions with IP6 and CypA

Author(s): Tao Ni 1 , Yanan Zhu 1 , Zhengyi Yang 2 , Chaoyi Xu 3 , Yuriy Chaban 2 , Tanya Nesterova 3 , Jiying Ning 4 , Till Böcking 5 , Michael W Parker 6 7 , Christina Monnie 4 , Jinwoo Ahn 4 , Juan R Perilla 3 , Peijun Zhang 1 2 8
Published in: Science advances, 2021, ISSN 2375-2548
Publisher: Science
DOI: 10.1126/sciadv.abj5715

Structural Analysis of Retrovirus Assembly and Maturation

Author(s): Anna-Sophia Krebs,1,† Luiza M. Mendonça,1,† and Peijun Zhang1,2,3,*
Published in: Viruses, 2022, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14010054

Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization

Author(s): Anna T. Gres,1,2 Karen A. Kirby,3,4 William M. McFadden,3 Haijuan Du,3 Dandan Liu,1,5 Chaoyi Xu,6 Alexander J. Bryer,6 Juan R. Perilla,6,7 Jiong Shi,8 Christopher Aiken,8 Xiaofeng Fu,9 Peijun Zhang,9,10,11 Ashwanth C. Francis,12,13 Gregory B. Melikyan,4,13 and Stefan G. Sarafianos
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-41197-7

Molecular architecture and conservation of an immature human endogenous retrovirus

Author(s): "Anna-Sophia Krebs # 1 , Hsuan-Fu Liu # 2 , Ye Zhou # 3 , Juan S Rey 4 , Lev Levintov 4 , Juan Shen 1 , Andrew Howe 5 , Juan R Perilla 6 , Alberto Bartesaghi 7 8 9 , Peijun Zhang 10 11 12"
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-40786-w

Intrinsically disordered CsoS2 acts as a general molecular thread for α-carboxysome shell assembly

Author(s): "Tao Ni,corresponding author#1,2 Qiuyao Jiang,#3 Pei Cing Ng,3 Juan Shen,1 Hao Dou,1 Yanan Zhu,1 Julika Radecke,4 Gregory F. Dykes,3 Fang Huang,3 Lu-Ning Liu,corresponding author3,5 and Peijun Zhangcorresponding author1,4,6"
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-41211-y

High-resolution in situ structure determination by cryo-electron tomography and subtomogram averaging using emClarity

Author(s): Ni T, Frosio T, Mendonça L, Sheng Y, Clare D, Himes BA, Zhang P
Published in: Nature Protocols, 2022, ISSN 1750-2799
Publisher: Springer Nature
DOI: 10.1038/s41596-021-00648-5

Recent structural advances in bacterial chemotaxis signalling

Author(s): Riechmann C, Zhang P
Published in: Curr Opin Struct Biol ., 2023, ISSN 1879-033X
Publisher: Elsevier
DOI: 10.1016/j.sbi.2023.102565

Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation

Author(s): Yu X, Ni T, Munson G, Zhang P, Gilbert RJC
Published in: The EMBO Journal, 2022, ISSN 1460-2075
Publisher: EMBO press
DOI: 10.15252/embj.2022111857

Conference proceedings (1)

Application of super-resolution and correlative double sampling in cryo-electron microscopy

Author(s): Sheng Y, Harrison PJ, Vogirala V, Yang Z, Strain-Damerell C, Frosio T, Himes BA, Siebert CA, Zhang P, Clare DK
Published in: Faraday Discussions, 2022
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2fd00049k