Molecular choreography of bacterial chemotaxis signalling

Informazioni relative al progetto

ChemoTaxi

ID dell’accordo di sovvenzione: 101021133

DOI

10.3030/101021133

Data della firma CE 22 Giugno 2021

Data di avvio 1 Settembre 2021

Data di completamento 31 Agosto 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 781 133,00

Contributo UE

€ 1 781 133,00

Coordinato da

DIAMOND LIGHT SOURCE LIMITED
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (26)

Neutral sphingomyelinase 2 is required for HIV-1 maturation

Autori: Abdul A Waheed 1 , Yanan Zhu 2 , Eva Agostino 1 , Lwar Naing 1 , Yuta Hikichi 1 , Ferri Soheilian 3 , Seung-Wan Yoo 4 , Yun Song 5 , Peijun Zhang 2 5 6 , Barbara S Slusher 4 7 8 , Norman J Haughey 4 8 , Eric O Freed 1
Pubblicato in: PNAS, 2023, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2219475120

Structure of the native chemotaxis core signaling unit from phage E-protein lysed E. coli cells

Autori: "C Keith Cassidy # 1 2 , Zhuan Qin # 3 , Thomas Frosio 1 , Khoosheh Gosink 4 , Zhengyi Yang 1 , Mark S P Sansom 5 , Phillip J Stansfeld 6 , John S Parkinson 4 , Peijun Zhang"
Pubblicato in: mBio, 2023, ISSN 2150-7511
Editore: ASM
DOI: 10.1128/mbio.00793-23

A structural view of the SARS-CoV-2 virus and its assembly

Autori: Hardenbrook N and Zhang P
Pubblicato in: Current Opinion in Virology, 2022, ISSN 1879-6265
Editore: Elsevier
DOI: 10.1016/j.coviro.2021.11.011

Cryogenic electron ptychographic single particle analysis with wide bandwidth information transfer

Autori: Xudong Pei; Liqi Zhou; Chen Huang; Mark Boyce; Judy S. Kim; Emanuela Liberti; Yiming Hu; Takeo Sasaki; Peter D. Nellist; Peijun Zhang; David I. Stuart; Angus I. Kirkland; Peng Wang
Pubblicato in: Nature Communications, Numero 1, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-38268-0

CryoEM structure of the super-constricted two-start dynamin 1 filament

Autori: Liu J, Alvarez FJD, Clare DK, Noel JK, Zhang P
Pubblicato in: Nature Communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-25741-x

ChAdOx1 COVID vaccines express RBD open prefusion SARS-CoV-2 spikes on the cell surface

Autori: Tao Ni,1,7,9 Luiza Mendonça,1,8,9 Yanan Zhu,1,9 Andrew Howe,2 Julika Radecke,2 Pranav M. Shah,1,3 Yuewen Sheng,2 Anna-Sophia Krebs,1 Helen M.E. Duyvesteyn,1 Elizabeth Allen,4 Teresa Lambe,4,5 Cameron Bisset,4 Alexandra Spencer,4 Susan Morris,6 David I. Stuart,1,2,3,6 Sarah Gilbert,4,5,6 and Peijun Zhang1,2,3,10,∗
Pubblicato in: iScience, 2023, ISSN 2589-0042
Editore: Elsevier Inc
DOI: 10.1016/j.isci.2023.107882

IceBreaker: Software for high-resolution single-particle cryo-EM with non-uniform ice

Autori: Olek M, Cowtan K, Webb D, Chaban Y, Zhang P
Pubblicato in: Structure, 2022, ISSN 0969-2126
Editore: Cell Press
DOI: 10.1016/j.str.2022.01.005

The Effect of Inositol Hexakisphosphate on HIV-1 Particle Production and Infectivity can be Modulated by Mutations that Affect the Stability of the Immature Gag Lattice

Autori: Alex B Kleinpeter 1 , Yanan Zhu 2 , Donna L Mallery 3 , Sherimay D Ablan 4 , Long Chen 2 , Nathan Hardenbrook 2 , Adolfo Saiardi 5 , Leo C James 6 , Peijun Zhang 7 , Eric O Freed 8
Pubblicato in: Journal of Molecular Biology, 2023, ISSN 0022-2836
Editore: Academic Press
DOI: 10.1016/j.jmb.2023.168037

Mechanisms of E. coli chemotaxis signaling pathways visualized using cryoET and computational approaches

Autori: Hadjidemetriou K, Kaur S, Cassidy CK, Zhang P
Pubblicato in: Biochem Soc Trans, 2022, ISSN 1470-8752
Editore: Biochemical Society
DOI: 10.1042/bst20220191

The molecular basis of regulation of bacterial capsule assembly by Wzc

Autori: Yang Y, Liu J, Clarke BR, Seidel L, Bolla JR, Ward PN, Zhang P, Robinson CV, Whitfield C, Naismith JH
Pubblicato in: Nature Communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-24652-1

Structure of native chromatin fibres revealed by Cryo-ET in situ

Autori: Zhen Hou, Frank Nightingale, Yanan Zhu, Craig MacGregor-Chatwin & Peijun Zhang
Pubblicato in: Nature Communications, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-42072-1

Probing the biogenesis pathway and dynamics of thylakoid membranes

Autori: Huokko T, Ni T, Dykes GF, Simpson DM, Brownridge P, Conradi FD, Beynon RJ, Nixon PJ, Mullineaux CW, Zhang P, Liu LN
Pubblicato in: Nature Communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-23680-1

Studying bacterial chemosensory array with CryoEM

Autori: Qin Z, Zhang P
Pubblicato in: Biochem Soc Trans, 2021, ISSN 1470-8752
Editore: Portland Press
DOI: 10.1042/bst20210080

Structure and assembly of cargo Rubisco in two native α-carboxysomes

Autori: Ni T, Sun Y, Burn W, Al-Hazeem MMJ, Zhu Y, Yu X, Liu LN, Zhang P
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-32004-w

Cryo-electron tomography to study viral infection

Autori: Miles Graham and Peijun Zhang
Pubblicato in: Biochem Soc Trans, 2023, ISSN 0300-5127
Editore: Portland Press, Ltd.
DOI: 10.1042/bst20230103

Cryo-electron Tomography Remote Data Collection and Subtomogram Averaging

Autori: Sheng Y, Morris K, Radecke J, Zhang P
Pubblicato in: JoVE, 2022, ISSN 1940-087X
Editore: MYJoVE Corporation
DOI: 10.3791/63923

Correlative multi-scale cryo-imaging unveils SARS-CoV-2 assembly and egress

Autori: Mendonça L, Howe A, Gilchrist JB, Sheng Y, Sun D, Knight ML, Zanetti-Domingues LC, Bateman B, Krebs AS, Chen L, Radecke J, Li VD, Ni T, Kounatidis I, Koronfel MA, Szynkiewicz M, Harkiolaki M, Martin-Fernandez ML, James W, Zhang P
Pubblicato in: Nature Communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-24887-y

Structure and activity of particulate methane monooxygenase arrays in methanotrophs

Autori: Zhu Y, Koo CW, Cassidy CK, Spink MC, Ni T, Zanetti-Domingues LC, Bateman B, Martin-Fernandez ML, Shen J, Sheng Y, Song Y, Yang Z, Rosenzweig AC, Zhang P
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-32752-9

Structure of native HIV-1 cores and their interactions with IP6 and CypA

Autori: Tao Ni 1 , Yanan Zhu 1 , Zhengyi Yang 2 , Chaoyi Xu 3 , Yuriy Chaban 2 , Tanya Nesterova 3 , Jiying Ning 4 , Till Böcking 5 , Michael W Parker 6 7 , Christina Monnie 4 , Jinwoo Ahn 4 , Juan R Perilla 3 , Peijun Zhang 1 2 8
Pubblicato in: Science advances, 2021, ISSN 2375-2548
Editore: Science
DOI: 10.1126/sciadv.abj5715

Structural Analysis of Retrovirus Assembly and Maturation

Autori: Anna-Sophia Krebs,1,† Luiza M. Mendonça,1,† and Peijun Zhang1,2,3,*
Pubblicato in: Viruses, 2022, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14010054

Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization

Autori: Anna T. Gres,1,2 Karen A. Kirby,3,4 William M. McFadden,3 Haijuan Du,3 Dandan Liu,1,5 Chaoyi Xu,6 Alexander J. Bryer,6 Juan R. Perilla,6,7 Jiong Shi,8 Christopher Aiken,8 Xiaofeng Fu,9 Peijun Zhang,9,10,11 Ashwanth C. Francis,12,13 Gregory B. Melikyan,4,13 and Stefan G. Sarafianos
Pubblicato in: Nature Communications, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-41197-7

Molecular architecture and conservation of an immature human endogenous retrovirus

Autori: "Anna-Sophia Krebs # 1 , Hsuan-Fu Liu # 2 , Ye Zhou # 3 , Juan S Rey 4 , Lev Levintov 4 , Juan Shen 1 , Andrew Howe 5 , Juan R Perilla 6 , Alberto Bartesaghi 7 8 9 , Peijun Zhang 10 11 12"
Pubblicato in: Nature Communications, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-40786-w

Intrinsically disordered CsoS2 acts as a general molecular thread for α-carboxysome shell assembly

Autori: "Tao Ni,corresponding author#1,2 Qiuyao Jiang,#3 Pei Cing Ng,3 Juan Shen,1 Hao Dou,1 Yanan Zhu,1 Julika Radecke,4 Gregory F. Dykes,3 Fang Huang,3 Lu-Ning Liu,corresponding author3,5 and Peijun Zhangcorresponding author1,4,6"
Pubblicato in: Nature Communications, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-41211-y

High-resolution in situ structure determination by cryo-electron tomography and subtomogram averaging using emClarity

Autori: Ni T, Frosio T, Mendonça L, Sheng Y, Clare D, Himes BA, Zhang P
Pubblicato in: Nature Protocols, 2022, ISSN 1750-2799
Editore: Springer Nature
DOI: 10.1038/s41596-021-00648-5

Recent structural advances in bacterial chemotaxis signalling

Autori: Riechmann C, Zhang P
Pubblicato in: Curr Opin Struct Biol ., 2023, ISSN 1879-033X
Editore: Elsevier
DOI: 10.1016/j.sbi.2023.102565

Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation

Autori: Yu X, Ni T, Munson G, Zhang P, Gilbert RJC
Pubblicato in: The EMBO Journal, 2022, ISSN 1460-2075
Editore: EMBO press
DOI: 10.15252/embj.2022111857

Conference proceedings (1)

Application of super-resolution and correlative double sampling in cryo-electron microscopy

Autori: Sheng Y, Harrison PJ, Vogirala V, Yang Z, Strain-Damerell C, Frosio T, Himes BA, Siebert CA, Zhang P, Clare DK
Pubblicato in: Faraday Discussions, 2022
Editore: Royal Society of Chemistry
DOI: 10.1039/d2fd00049k