Molecular choreography of bacterial chemotaxis signalling

Información del proyecto

ChemoTaxi

Identificador del acuerdo de subvención: 101021133

DOI

10.3030/101021133

Fecha de la firma de la CE 22 Junio 2021

Fecha de inicio 1 Septiembre 2021

Fecha de finalización 31 Agosto 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 781 133,00

Aportación de la UE

€ 1 781 133,00

Coordinado por

DIAMOND LIGHT SOURCE LIMITED
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (26)

Neutral sphingomyelinase 2 is required for HIV-1 maturation

Autores: Abdul A Waheed 1 , Yanan Zhu 2 , Eva Agostino 1 , Lwar Naing 1 , Yuta Hikichi 1 , Ferri Soheilian 3 , Seung-Wan Yoo 4 , Yun Song 5 , Peijun Zhang 2 5 6 , Barbara S Slusher 4 7 8 , Norman J Haughey 4 8 , Eric O Freed 1
Publicado en: PNAS, 2023, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2219475120

Structure of the native chemotaxis core signaling unit from phage E-protein lysed E. coli cells

Autores: "C Keith Cassidy # 1 2 , Zhuan Qin # 3 , Thomas Frosio 1 , Khoosheh Gosink 4 , Zhengyi Yang 1 , Mark S P Sansom 5 , Phillip J Stansfeld 6 , John S Parkinson 4 , Peijun Zhang"
Publicado en: mBio, 2023, ISSN 2150-7511
Editor: ASM
DOI: 10.1128/mbio.00793-23

A structural view of the SARS-CoV-2 virus and its assembly

Autores: Hardenbrook N and Zhang P
Publicado en: Current Opinion in Virology, 2022, ISSN 1879-6265
Editor: Elsevier
DOI: 10.1016/j.coviro.2021.11.011

Cryogenic electron ptychographic single particle analysis with wide bandwidth information transfer

Autores: Xudong Pei; Liqi Zhou; Chen Huang; Mark Boyce; Judy S. Kim; Emanuela Liberti; Yiming Hu; Takeo Sasaki; Peter D. Nellist; Peijun Zhang; David I. Stuart; Angus I. Kirkland; Peng Wang
Publicado en: Nature Communications, Edición 1, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-38268-0

CryoEM structure of the super-constricted two-start dynamin 1 filament

Autores: Liu J, Alvarez FJD, Clare DK, Noel JK, Zhang P
Publicado en: Nature Communications, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-25741-x

ChAdOx1 COVID vaccines express RBD open prefusion SARS-CoV-2 spikes on the cell surface

Autores: Tao Ni,1,7,9 Luiza Mendonça,1,8,9 Yanan Zhu,1,9 Andrew Howe,2 Julika Radecke,2 Pranav M. Shah,1,3 Yuewen Sheng,2 Anna-Sophia Krebs,1 Helen M.E. Duyvesteyn,1 Elizabeth Allen,4 Teresa Lambe,4,5 Cameron Bisset,4 Alexandra Spencer,4 Susan Morris,6 David I. Stuart,1,2,3,6 Sarah Gilbert,4,5,6 and Peijun Zhang1,2,3,10,∗
Publicado en: iScience, 2023, ISSN 2589-0042
Editor: Elsevier Inc
DOI: 10.1016/j.isci.2023.107882

IceBreaker: Software for high-resolution single-particle cryo-EM with non-uniform ice

Autores: Olek M, Cowtan K, Webb D, Chaban Y, Zhang P
Publicado en: Structure, 2022, ISSN 0969-2126
Editor: Cell Press
DOI: 10.1016/j.str.2022.01.005

The Effect of Inositol Hexakisphosphate on HIV-1 Particle Production and Infectivity can be Modulated by Mutations that Affect the Stability of the Immature Gag Lattice

Autores: Alex B Kleinpeter 1 , Yanan Zhu 2 , Donna L Mallery 3 , Sherimay D Ablan 4 , Long Chen 2 , Nathan Hardenbrook 2 , Adolfo Saiardi 5 , Leo C James 6 , Peijun Zhang 7 , Eric O Freed 8
Publicado en: Journal of Molecular Biology, 2023, ISSN 0022-2836
Editor: Academic Press
DOI: 10.1016/j.jmb.2023.168037

Mechanisms of E. coli chemotaxis signaling pathways visualized using cryoET and computational approaches

Autores: Hadjidemetriou K, Kaur S, Cassidy CK, Zhang P
Publicado en: Biochem Soc Trans, 2022, ISSN 1470-8752
Editor: Biochemical Society
DOI: 10.1042/bst20220191

The molecular basis of regulation of bacterial capsule assembly by Wzc

Autores: Yang Y, Liu J, Clarke BR, Seidel L, Bolla JR, Ward PN, Zhang P, Robinson CV, Whitfield C, Naismith JH
Publicado en: Nature Communications, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-24652-1

Structure of native chromatin fibres revealed by Cryo-ET in situ

Autores: Zhen Hou, Frank Nightingale, Yanan Zhu, Craig MacGregor-Chatwin & Peijun Zhang
Publicado en: Nature Communications, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-42072-1

Probing the biogenesis pathway and dynamics of thylakoid membranes

Autores: Huokko T, Ni T, Dykes GF, Simpson DM, Brownridge P, Conradi FD, Beynon RJ, Nixon PJ, Mullineaux CW, Zhang P, Liu LN
Publicado en: Nature Communications, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-23680-1

Studying bacterial chemosensory array with CryoEM

Autores: Qin Z, Zhang P
Publicado en: Biochem Soc Trans, 2021, ISSN 1470-8752
Editor: Portland Press
DOI: 10.1042/bst20210080

Structure and assembly of cargo Rubisco in two native α-carboxysomes

Autores: Ni T, Sun Y, Burn W, Al-Hazeem MMJ, Zhu Y, Yu X, Liu LN, Zhang P
Publicado en: Nature Communications, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-32004-w

Cryo-electron tomography to study viral infection

Autores: Miles Graham and Peijun Zhang
Publicado en: Biochem Soc Trans, 2023, ISSN 0300-5127
Editor: Portland Press, Ltd.
DOI: 10.1042/bst20230103

Cryo-electron Tomography Remote Data Collection and Subtomogram Averaging

Autores: Sheng Y, Morris K, Radecke J, Zhang P
Publicado en: JoVE, 2022, ISSN 1940-087X
Editor: MYJoVE Corporation
DOI: 10.3791/63923

Correlative multi-scale cryo-imaging unveils SARS-CoV-2 assembly and egress

Autores: Mendonça L, Howe A, Gilchrist JB, Sheng Y, Sun D, Knight ML, Zanetti-Domingues LC, Bateman B, Krebs AS, Chen L, Radecke J, Li VD, Ni T, Kounatidis I, Koronfel MA, Szynkiewicz M, Harkiolaki M, Martin-Fernandez ML, James W, Zhang P
Publicado en: Nature Communications, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-24887-y

Structure and activity of particulate methane monooxygenase arrays in methanotrophs

Autores: Zhu Y, Koo CW, Cassidy CK, Spink MC, Ni T, Zanetti-Domingues LC, Bateman B, Martin-Fernandez ML, Shen J, Sheng Y, Song Y, Yang Z, Rosenzweig AC, Zhang P
Publicado en: Nature Communications, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-32752-9

Structure of native HIV-1 cores and their interactions with IP6 and CypA

Autores: Tao Ni 1 , Yanan Zhu 1 , Zhengyi Yang 2 , Chaoyi Xu 3 , Yuriy Chaban 2 , Tanya Nesterova 3 , Jiying Ning 4 , Till Böcking 5 , Michael W Parker 6 7 , Christina Monnie 4 , Jinwoo Ahn 4 , Juan R Perilla 3 , Peijun Zhang 1 2 8
Publicado en: Science advances, 2021, ISSN 2375-2548
Editor: Science
DOI: 10.1126/sciadv.abj5715

Structural Analysis of Retrovirus Assembly and Maturation

Autores: Anna-Sophia Krebs,1,† Luiza M. Mendonça,1,† and Peijun Zhang1,2,3,*
Publicado en: Viruses, 2022, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14010054

Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization

Autores: Anna T. Gres,1,2 Karen A. Kirby,3,4 William M. McFadden,3 Haijuan Du,3 Dandan Liu,1,5 Chaoyi Xu,6 Alexander J. Bryer,6 Juan R. Perilla,6,7 Jiong Shi,8 Christopher Aiken,8 Xiaofeng Fu,9 Peijun Zhang,9,10,11 Ashwanth C. Francis,12,13 Gregory B. Melikyan,4,13 and Stefan G. Sarafianos
Publicado en: Nature Communications, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-41197-7

Molecular architecture and conservation of an immature human endogenous retrovirus

Autores: "Anna-Sophia Krebs # 1 , Hsuan-Fu Liu # 2 , Ye Zhou # 3 , Juan S Rey 4 , Lev Levintov 4 , Juan Shen 1 , Andrew Howe 5 , Juan R Perilla 6 , Alberto Bartesaghi 7 8 9 , Peijun Zhang 10 11 12"
Publicado en: Nature Communications, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-40786-w

Intrinsically disordered CsoS2 acts as a general molecular thread for α-carboxysome shell assembly

Autores: "Tao Ni,corresponding author#1,2 Qiuyao Jiang,#3 Pei Cing Ng,3 Juan Shen,1 Hao Dou,1 Yanan Zhu,1 Julika Radecke,4 Gregory F. Dykes,3 Fang Huang,3 Lu-Ning Liu,corresponding author3,5 and Peijun Zhangcorresponding author1,4,6"
Publicado en: Nature Communications, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-41211-y

High-resolution in situ structure determination by cryo-electron tomography and subtomogram averaging using emClarity

Autores: Ni T, Frosio T, Mendonça L, Sheng Y, Clare D, Himes BA, Zhang P
Publicado en: Nature Protocols, 2022, ISSN 1750-2799
Editor: Springer Nature
DOI: 10.1038/s41596-021-00648-5

Recent structural advances in bacterial chemotaxis signalling

Autores: Riechmann C, Zhang P
Publicado en: Curr Opin Struct Biol ., 2023, ISSN 1879-033X
Editor: Elsevier
DOI: 10.1016/j.sbi.2023.102565

Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation

Autores: Yu X, Ni T, Munson G, Zhang P, Gilbert RJC
Publicado en: The EMBO Journal, 2022, ISSN 1460-2075
Editor: EMBO press
DOI: 10.15252/embj.2022111857

Conference proceedings (1)

Application of super-resolution and correlative double sampling in cryo-electron microscopy

Autores: Sheng Y, Harrison PJ, Vogirala V, Yang Z, Strain-Damerell C, Frosio T, Himes BA, Siebert CA, Zhang P, Clare DK
Publicado en: Faraday Discussions, 2022
Editor: Royal Society of Chemistry
DOI: 10.1039/d2fd00049k