Electrochemical-mediated site-selective halogenation of phenol as a platform for accessing poly-substituted arenes.

Información del proyecto

ElectroPheX

Identificador del acuerdo de subvención: 101023375

DOI

10.3030/101023375

Proyecto cerrado

Fecha de la firma de la CE 13 Marzo 2021

Fecha de inicio 1 Junio 2021

Fecha de finalización 31 Julio 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 246 669,12

Aportación de la UE

€ 246 669,12

Coordinado por

MAX PLANCK INSTITUT FUER KOHLENFORSCHUNG
Germany

Periodic Reporting for period 2 - ElectroPheX (Electrochemical-mediated site-selective halogenation of phenol as a platform for accessing poly-substituted arenes.)

Período documentado: 2023-06-01 hasta 2024-05-31

Resumen del contexto y de los objetivos generales del proyecto

Poly-substituted aromatics (PSAs) are of paramount importance in Organic Chemistry (synthesis intermediates), Medicinal Chemistry (pharmaceutical compounds) and material Science. The highly hindered nature of these compounds makes their synthesis a longstanding challenge for the synthetic community.
Thus, the development of tools that will allow us to access them in a selective manner are of interest. ElectroPheX aims to develop synthetic methodologies that successfully access poly-substituted aromatics by first halogenate (X) Phenols under Electrochemical conditions.

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

Three different methodologies for the site-selective halogenation of phenols have been proposed. During the last 24 months it was shown whether these methods can be candidates to solve this challenging problem. Valuable information has been acquired that will help address the issues in a more efficient way.

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

A novel methodology for the selective functionalization of every position of a phenolic ring will be developed that will have a translational impact on multiple research areas (Medicinal Chemistry, Radiolabelling, Organic Chemistry, material Science).

Overall action after redesign

Description of the main objectives of the ElectroPheX and its translation nature.

Abstract of the synthesis of Cyclopamine

Overview of the ElectroPheX