Electrochemical-mediated site-selective halogenation of phenol as a platform for accessing poly-substituted arenes.

Informazioni relative al progetto

ElectroPheX

ID dell’accordo di sovvenzione: 101023375

DOI

10.3030/101023375

Progetto chiuso

Data della firma CE 13 Marzo 2021

Data di avvio 1 Giugno 2021

Data di completamento 31 Luglio 2024

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 246 669,12

Contributo UE

€ 246 669,12

Coordinato da

MAX PLANCK INSTITUT FUER KOHLENFORSCHUNG
Germany

Periodic Reporting for period 2 - ElectroPheX (Electrochemical-mediated site-selective halogenation of phenol as a platform for accessing poly-substituted arenes.)

Periodo di rendicontazione: 2023-06-01 al 2024-05-31

Sintesi del contesto e degli obiettivi generali del progetto

Poly-substituted aromatics (PSAs) are of paramount importance in Organic Chemistry (synthesis intermediates), Medicinal Chemistry (pharmaceutical compounds) and material Science. The highly hindered nature of these compounds makes their synthesis a longstanding challenge for the synthetic community.
Thus, the development of tools that will allow us to access them in a selective manner are of interest. ElectroPheX aims to develop synthetic methodologies that successfully access poly-substituted aromatics by first halogenate (X) Phenols under Electrochemical conditions.

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

Three different methodologies for the site-selective halogenation of phenols have been proposed. During the last 24 months it was shown whether these methods can be candidates to solve this challenging problem. Valuable information has been acquired that will help address the issues in a more efficient way.

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

A novel methodology for the selective functionalization of every position of a phenolic ring will be developed that will have a translational impact on multiple research areas (Medicinal Chemistry, Radiolabelling, Organic Chemistry, material Science).

Overall action after redesign

Description of the main objectives of the ElectroPheX and its translation nature.

Abstract of the synthesis of Cyclopamine

Overview of the ElectroPheX