Periodic Reporting for period 2 - ElectroPheX (Electrochemical-mediated site-selective halogenation of phenol as a platform for accessing poly-substituted arenes.)
Okres sprawozdawczy: 2023-06-01 do 2024-05-31
Poly-substituted aromatics (PSAs) are of paramount importance in Organic Chemistry (synthesis intermediates), Medicinal Chemistry (pharmaceutical compounds) and material Science. The highly hindered nature of these compounds makes their synthesis a longstanding challenge for the synthetic community.
Thus, the development of tools that will allow us to access them in a selective manner are of interest. ElectroPheX aims to develop synthetic methodologies that successfully access poly-substituted aromatics by first halogenate (X) Phenols under Electrochemical conditions.
Thus, the development of tools that will allow us to access them in a selective manner are of interest. ElectroPheX aims to develop synthetic methodologies that successfully access poly-substituted aromatics by first halogenate (X) Phenols under Electrochemical conditions.
Three different methodologies for the site-selective halogenation of phenols have been proposed. During the last 24 months it was shown whether these methods can be candidates to solve this challenging problem. Valuable information has been acquired that will help address the issues in a more efficient way.
A novel methodology for the selective functionalization of every position of a phenolic ring will be developed that will have a translational impact on multiple research areas (Medicinal Chemistry, Radiolabelling, Organic Chemistry, material Science).