Electrochemical-mediated site-selective halogenation of phenol as a platform for accessing poly-substituted arenes.

Informacje na temat projektu

ElectroPheX

Identyfikator umowy o grant: 101023375

DOI

10.3030/101023375

Projekt został zamknięty

Data podpisania przez KE 13 Marca 2021

Data rozpoczęcia 1 Czerwca 2021

Data zakończenia 31 Lipca 2024

Finansowanie w ramach

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Koszt całkowity

€ 246 669,12

Wkład UE

€ 246 669,12

Koordynowany przez

MAX PLANCK INSTITUT FUER KOHLENFORSCHUNG
Germany

Periodic Reporting for period 2 - ElectroPheX (Electrochemical-mediated site-selective halogenation of phenol as a platform for accessing poly-substituted arenes.)

Okres sprawozdawczy: 2023-06-01 do 2024-05-31

Podsumowanie kontekstu i ogólnych celów projektu

Poly-substituted aromatics (PSAs) are of paramount importance in Organic Chemistry (synthesis intermediates), Medicinal Chemistry (pharmaceutical compounds) and material Science. The highly hindered nature of these compounds makes their synthesis a longstanding challenge for the synthetic community.
Thus, the development of tools that will allow us to access them in a selective manner are of interest. ElectroPheX aims to develop synthetic methodologies that successfully access poly-substituted aromatics by first halogenate (X) Phenols under Electrochemical conditions.

Prace wykonane od początku projektu do końca okresu sprawozdawczego oraz najważniejsze dotychczasowe rezultaty

Three different methodologies for the site-selective halogenation of phenols have been proposed. During the last 24 months it was shown whether these methods can be candidates to solve this challenging problem. Valuable information has been acquired that will help address the issues in a more efficient way.

Innowacyjność oraz oczekiwany potencjalny wpływ (w tym dotychczasowe znaczenie społeczno-gospodarcze i szersze implikacje społeczne projektu)

A novel methodology for the selective functionalization of every position of a phenolic ring will be developed that will have a translational impact on multiple research areas (Medicinal Chemistry, Radiolabelling, Organic Chemistry, material Science).

Overall action after redesign

Description of the main objectives of the ElectroPheX and its translation nature.

Abstract of the synthesis of Cyclopamine

Overview of the ElectroPheX