Electrochemical-mediated site-selective halogenation of phenol as a platform for accessing poly-substituted arenes.

Projektinformationen

ElectroPheX

ID Finanzhilfevereinbarung: 101023375

DOI

10.3030/101023375

Projekt abgeschlossen

EK-Unterschriftsdatum 13 März 2021

Startdatum 1 Juni 2021

Enddatum 31 Juli 2024

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten

€ 246 669,12

EU-Beitrag

€ 246 669,12

Koordiniert durch

MAX PLANCK INSTITUT FUER KOHLENFORSCHUNG
Germany

Periodic Reporting for period 2 - ElectroPheX (Electrochemical-mediated site-selective halogenation of phenol as a platform for accessing poly-substituted arenes.)

Berichtszeitraum: 2023-06-01 bis 2024-05-31

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

Poly-substituted aromatics (PSAs) are of paramount importance in Organic Chemistry (synthesis intermediates), Medicinal Chemistry (pharmaceutical compounds) and material Science. The highly hindered nature of these compounds makes their synthesis a longstanding challenge for the synthetic community.
Thus, the development of tools that will allow us to access them in a selective manner are of interest. ElectroPheX aims to develop synthetic methodologies that successfully access poly-substituted aromatics by first halogenate (X) Phenols under Electrochemical conditions.

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

Three different methodologies for the site-selective halogenation of phenols have been proposed. During the last 24 months it was shown whether these methods can be candidates to solve this challenging problem. Valuable information has been acquired that will help address the issues in a more efficient way.

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

A novel methodology for the selective functionalization of every position of a phenolic ring will be developed that will have a translational impact on multiple research areas (Medicinal Chemistry, Radiolabelling, Organic Chemistry, material Science).

Overall action after redesign

Description of the main objectives of the ElectroPheX and its translation nature.

Abstract of the synthesis of Cyclopamine

Overview of the ElectroPheX