Electrochemical-mediated site-selective halogenation of phenol as a platform for accessing poly-substituted arenes.

Informations projet

ElectroPheX

N° de convention de subvention: 101023375

DOI

10.3030/101023375

Projet clôturé

Date de signature de la CE 13 Mars 2021

Date de début 1 Juin 2021

Date de fin 31 Juillet 2024

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 246 669,12

Contribution de l’UE

€ 246 669,12

Coordonné par

MAX PLANCK INSTITUT FUER KOHLENFORSCHUNG
Germany

Periodic Reporting for period 2 - ElectroPheX (Electrochemical-mediated site-selective halogenation of phenol as a platform for accessing poly-substituted arenes.)

Période du rapport: 2023-06-01 au 2024-05-31

Résumé du contexte et des objectifs généraux du projet

Poly-substituted aromatics (PSAs) are of paramount importance in Organic Chemistry (synthesis intermediates), Medicinal Chemistry (pharmaceutical compounds) and material Science. The highly hindered nature of these compounds makes their synthesis a longstanding challenge for the synthetic community.
Thus, the development of tools that will allow us to access them in a selective manner are of interest. ElectroPheX aims to develop synthetic methodologies that successfully access poly-substituted aromatics by first halogenate (X) Phenols under Electrochemical conditions.

Travail effectué depuis le début du projet jusqu’à la fin de la période considérée dans le rapport et principaux résultats atteints jusqu’à présent

Three different methodologies for the site-selective halogenation of phenols have been proposed. During the last 24 months it was shown whether these methods can be candidates to solve this challenging problem. Valuable information has been acquired that will help address the issues in a more efficient way.

Progrès au-delà de l’état des connaissances et impact potentiel prévu (y compris l’impact socio-économique et les conséquences sociétales plus larges du projet jusqu’à présent)

A novel methodology for the selective functionalization of every position of a phenolic ring will be developed that will have a translational impact on multiple research areas (Medicinal Chemistry, Radiolabelling, Organic Chemistry, material Science).

Overall action after redesign

Description of the main objectives of the ElectroPheX and its translation nature.

Abstract of the synthesis of Cyclopamine

Overview of the ElectroPheX