Periodic Reporting for period 1 - DmGAR (Uncovering antiviral mechanisms in the insect gut during oral virus infection)
Okres sprawozdawczy: 2022-01-01 do 2023-12-31
The goal of DmGAR was to provide a comprehensive understanding of host-virus interactions during enteric viral infection in the Drosophila melanogaster model. We sought to answer the following questions: What are the dynamics and outcomes of viral infection in the intestine? What are the genetic responses to enteric viral infection? How does viral infection impact intestinal homeostasis? By addressing these questions our goal was to uncover crucial roles of the gut epithelium in responding to viral infection and to understand how the gut response to infection influences organismal health.
The results of the project were disseminated through international conference presentations, open access preprints, and social media posts targets to a general audience. Specifically, the results of DmGAR were presented during the “Flying Through the Gut” public seminar series (Zoom, April 2022), the European Society for Human Genetics conference (Vienna, Austria, June 2022), the American Society for Virology annual meeting (Madison, WI, USA, July 2022), the EMBO | EMBL Symposia “Innate immunity in Host Pathogen Interactions” (Heidelberg, Germany, July 2022), and the Jacques Monod conference “Insect Models for Infection Biology” (Roscoff, France, June 2023). The main results of the project were posted as a BioRxiv preprint that is currently undergoing peer review (https://doi.org/10.1101/2023.11.16.567400) and were summarized for a general audience in a public post on social media (https://twitter.com/SalehLabParis/status/1725530496137052253).