Description du projet
Voies de régulation des lysosomes
Les lysosomes, organites cellulaires contenant des enzymes hydrolytiques, participent aux processus physiologiques clés des cellules. Le dysfonctionnement des lysosomes est réputé pour son implication dans l’apparition d’un grand nombre de maladies humaines. En outre, la plupart des fonctions assurées par les lysosomes dépendent des activités hydrolytiques au sein de leur lumière. Néanmoins, la régulation des activités des lysosomes et leur rôle dans la gouvernance du destin cellulaire soulèvent encore des questions cruciales. Par conséquent, une compréhension plus approfondie des voies de signalisation régissant la régulation des lysosomes pourrait apporter de nouveaux outils thérapeutiques pour traiter ces maladies. Le projet CytoLysoReg, financé par l’UE, étudiera les propriétés moléculaires et biophysiques qui permettent aux cytokines de réguler les lysosomes. Son objectif est de permettre aux scientifiques de manipuler les lysosomes dans le but de traiter les maladies liées aux lysosomes.
Objectif
Dysfunction of lysosomes—the recycling plants of cells, now recognised to participate in multiple aspects of cell physiology—is involved at the onset of several human diseases. Importantly, most of the functions carried out by lysosomes depend on hydrolytic activities within their lumen. Thus, a deeper understanding of the signalling pathways involved in the regulation of lysosomes would provide new tools to ameliorate the symptoms associated with these diseases. The regulation of lysosomal gene expression was partially elucidated by the discovery of the role played by the mTOR-TFEB axis during starvation. However, as recently shown by the researcher (Nature Comm 2018) and others the cytokines-STAT3 axis also contributes to lysosomal regulation. However, the molecular mechanisms of the cytokine-mediated lysosomal regulation still remain unresolved. Thus, the herein proposed project (CytoLysoReg) is aimed at unveiling the molecular and biophysical properties allowing cytokines to regulate lysosomes. CytoLysoReg is an innovative, multidisciplinary project based on international collaborations and preliminary data generated by the researcher during his work as Senior Research Associate at the University of Dundee. The data generated during the execution of CytoLysoReg on lysosomal regulation will allow us to manipulate lysosomes as an approach to treat lysosomal-related diseases (e.g. cancer, LSDs). The role of Prof. Diaz-Quintana as supervisor will be essential, providing his expertise in biophysics and protein structure, and facilitating the integration of the researcher into the host institution (IIQ-Seville). Finally, after finishing the MSCA-IF fellowship, the researcher will be invited to develop his independent scientific career and reinforce the Biological Chemistry line—considered a strategic research line to be developed at the host institute—at the IIQ-Seville thanks to the ongoing MSCA Fellows Stabilisation and Recruitment of Talent Programme of the US.
Champ scientifique
- engineering and technologyenvironmental engineeringwaste managementwaste treatment processesrecycling
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- medical and health sciencesclinical medicineoncology
- medical and health sciencesbasic medicinephysiology
- natural sciencesbiological sciencesbiophysics
Programme(s)
Régime de financement
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinateur
41004 Sevilla
Espagne