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Biodegradable bottlebrush polycarbonates with benzophenone groups for the preparation of tissue engineering scaffolds

Descrizione del progetto

Nuovi biomateriali per l’ingegneria dei tessuti

I policarbonati alifatici sono composti che contengono il gruppo chimico -O-C(O)-O- in una struttura non aromatica. Gli ultimi anni hanno visto un rinnovato interesse per queste molecole dovuto ai progressi nella produzione. Le loro interessanti caratteristiche comprendono la biocompatibilità e la degradazione priva di acidi, rendendo i policarbonati alifatici ideali per i biomateriali in quanto non provocano infiammazioni tissutali. Inoltre, possono essere funzionalizzati e quindi usati come impianti e veicoli di farmaci. Il progetto PhotoPolyCarb, finanziato dall’UE, sta lavorando a un approccio di stampa 3D che utilizza policarbonati alifatici per generare biomateriali per scopi di ingegneria tissutale. L’approccio costituisce un passo avanti verso lo sviluppo di impianti su misura, che hanno il potenziale per migliorare la salute e la qualità della vita dei pazienti.

Obiettivo

Over the past years, aliphatic polycarbonates (APCs) have gained prominence in the biomedical field in reason of their features allied to their in vivo bioresorbability. Unlike polyesters, the degradation products of APCs are acid free, which prevents tissue inflammation and drug denaturation upon their use as implants and drug vehicles, making them a potential material in the medical field. Simultaneously, the 3D printing of biomaterials has recently advanced the development of tailor-made implants, which can improve the patients’ health and quality of life. However, the translative impact of 3D printing to clinical use is still beset with limitations, including the brittle nature of the properties of materials that are available, the crosslinking chemistries that hinder translation into cell-laden biomaterials and toxicity of residual monomers and additives. PhotoPolyCarb aims to overcome these limitations by combining functional photoreactive polycarbonates from different topographies with stereolithography (SLA), thus avoiding the use of toxic monomers and photoinitiators during the printing process. In a transfer of knowledge, PhotoPolyCarb will bring together the expertise of the researchers in areas such as chemical engineering reactions (from the applicant), polymer chemistry (from the host) and bioengineering (from the secondment). The fellowship will permit the applicant to work with world-renowned research groups in the field of biomaterials and tissue engineering, allowing her to develop skills in an interdisciplinary environment and consolidate her career. The dissemination of research results will target the professional audience as well the public through outreach activities.

Coordinatore

THE UNIVERSITY OF BIRMINGHAM
Contribution nette de l'UE
€ 212 933,76
Indirizzo
Edgbaston
B15 2TT Birmingham
Regno Unito

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Regione
West Midlands (England) West Midlands Birmingham
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
€ 212 933,76