Descrizione del progetto
Un sensore nei capezzoli per monitorare l’efficienza della lattazione
Secondo le raccomandazioni dell’OMS l’allattamento è consigliato per i primi sei mesi di vita, il che sottolinea l’importanza del latte materno nella salute dei neonati. Ciononostante, una percentuale significativa di donne incontra problemi nel produrre una quantità di latte sufficiente. Il progetto LactIns-and-outs, finanziato dall’UE, è interessato a comprendere le cause alla radice dell’insufficienza di lattazione e a determinare la composizione del latte durante l’allattamento. A tal fine, gli scienziati svilupperanno un sensore compatto ingegnerizzato in una protezione per capezzoli che integrerà un metodo a base ottica in grado di caratterizzare i globuli di grasso nel latte e di misurare i parametri fisiologici della mammella in tempo reale. L’implementazione di questo sensore migliorerà gli esiti dell’allattamento e contribuirà a diagnosticare i casi di insufficienza di lattazione.
Obiettivo
Breastfeeding is important for infant and maternal health. However, 10-15% of breastfeeding women fail to produce enough milk, while 40-50% give up early because of perceived insufficiency. As a result, only a minority meet the WHO recommendation to exclusively breastfeed during the first six months. To address this public health challenge, two key questions need to be solved: What do nursing infants actually drink? And how is this milk transfer regulated by mammary physiology?
My vision is to pioneer new, quantitative methods that allow to solve these fundamental questions. Building on my expertise in biophotonic innovations for neonatal care, I propose to develop non-invasive optical tools to quantify milk transfer in situ (WP1) and map the causes of lactation insufficiency from the largely unexplored perspective of mammary physiology (WP2).
In WP1, the scientific challenge is to develop methods for inline monitoring of both the milk volume consumed and its varying composition during a breastfeed. I propose two novel optical methods based on light scattering by milk fat globules, building upon laser Doppler flowmetry (volumetric flow rate) and angular resolved light scattering spectroscopy (composition). The technological challenge is to integrate both methods into a safe, compact sensor prototype, engineered into a nipple shield.
In WP2, I will translate the technology of Diffuse Optical Spectroscopic Imaging (DOSI) to lactation science. Here, the scientific challenge is to quantify mammary physiological parameters in real-time, using DOSI and my sensor from WP1 during live breastfeeds. In both WPs, I will use state-of-the-art (medical) ultrasound for validation.
By engineering dedicated tools for lactation research, this project will enable a leap forward in the diagnosis, treatment and prevention of both actual and perceived lactation insufficiency. In turn, this will lead to better breastfeeding support and improved individual and public health outcomes.
Campo scientifico
- medical and health scienceshealth sciencesnursing
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensors
- medical and health sciencesbasic medicinephysiology
- natural sciencesphysical sciencesacousticsultrasound
- natural sciencesphysical sciencesopticsspectroscopy
Programma(i)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Argomento(i)
Meccanismo di finanziamento
HORIZON-AG - HORIZON Action Grant Budget-BasedIstituzione ospitante
7522 NB Enschede
Paesi Bassi