RNA PROCESSING FOR ANTI-CANCER IMMUNOTHERAPY

Información del proyecto

CANCERNA

Identificador del acuerdo de subvención: 101057250

DOI

10.3030/101057250

Proyecto cerrado

Fecha de la firma de la CE 19 Mayo 2022

Fecha de inicio 1 Junio 2022

Fecha de finalización 31 Mayo 2025

Financiado con arreglo a

• Health

Coste total

€ 5 999 381,25

Aportación de la UE

€ 5 999 381,00

Coordinado por

HADASSAH MEDICAL ORGANIZATION
Israel

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Data sets, microdata, etc (2)

List of altered transcripts and NMD-prone transcripts

a. List of altered transcripts, which are induced by the presence of splicing factor mutations and generate predicted immunogenic peptides (M18)b.List of NMD-prone transcripts which are induced by the presence of NMD inhibitors generate predicted immunogenic peptides (M18)

Bio-bank of tumour samples and generation of RNA-seq datasets

a. Bio-bank of tumour samples (uveal melanoma and MDS/AML) harbouring mutations in splicing factor genes (M12)b.Generation of RNA-seq datasets and splicing analysis of tumour samples (uveal melanoma and MDS/AML) harbouring mutations in splicing factor genes (M18)

Websites, patent fillings, videos etc. (1)

CANCERNA project website and social media platforms

Other (1)

Selection of a reproducible method to be adopted by participating groups, of mRNA-loaded APC preparation for vaccine epitope presentation.

Publicaciones

Peer reviewed articles (16)

The future of affordable cancer immunotherapy

Autores: Schaft N, Dörrie J, Schuler G, Schuler-Thurner B, Sallam H, Klein S, Eisenberg G, Frankenburg S, Lotem M, Khatib A.
Publicado en: Frontiers in Immunology, Edición 1248867, 2023, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/fimmu.2023.1248867

Tumor Antigens beyond the Human Exome

Autores: Lisabeth Emilius, Franziska Bremm, Amanda Katharina Binder, Niels Schaft, Jan Dörrie
Publicado en: International Journal of Molecular Sciences, Edición 25, 2025, ISSN 1422-0067
Editor: MDPI AG
DOI: 10.3390/IJMS25094673

Cancers

Autores: S. Matos, P. Bernardo, S. Esteves, A.B.d. Sousa, M. Lemos, P. Ribeiro, M. Silva, A. Nunes, J. Lobato, M.d.J. Frade, M.G.da. S, S. Chacim, J. Mariz, G. Esteves,J. Raposo, A. Espadana, J. Carda, P. Barbosa, V. Martins, M. Carmo-Fonseca, J. Desterro
Publicado en: Cancers, Edición 14133236, 2022, ISSN 2072-6694
Editor: MDPI
DOI: 10.3390/cancers14133236

Spliced to kill: RNA mis-splicing derived cancer neoantigens

Autores: Anurag V. Prabhu, Carla Azar-Koussa, Zahava Siegfried, Rotem Karni
Publicado en: Trends in Cancer, 2025, ISSN 2405-8033
Editor: Elsevier BV
DOI: 10.1016/J.TRECAN.2025.06.001

Targeting splicing factors for cancer therapy

Autores: Ariel Bashari, Zahava Siegfried, Rotem Karni
Publicado en: RNA, Edición 29, 2023, ISSN 1355-8382
Editor: Cold Spring Harbor Laboratory
DOI: 10.1261/RNA.079585.123

Gene network-based and ensemble modeling-based selection of tumor-associated antigens with a predicted low risk of tissue damage for targeted immunotherapy

Autores: Christopher Lischer, Martin Eberhardt, Cindy Flamann, Johannes Berges, Esther Güse, Anja Wessely, Adrian Weich, Jimmy Retzlaff, Jan Dörrie, Niels Schaft, Manuel Wiesinger, Johannes März, Beatrice Schuler-Thurner, Harald Knorr, Shailendra Gupta, Krishna Pal Singh, Gerold Schuler, Markus Vincent Heppt, Elias Andreas Thomas Koch, Nadine D van Kleef, Julian J Freen-van Heeren, Annelies W Turksma, Olaf Wolkenhauer, Bettina Hohberger, Carola Berking, Heiko Bruns, Julio Vera
Publicado en: Journal for ImmunoTherapy of Cancer, Edición 12, 2024, ISSN 2051-1426
Editor: BMJ
DOI: 10.1136/JITC-2023-008104

Generation of tumor neoantigens by RNA splicing perturbation

Autores: Adi Rosenberg-Mogilevsky, Zahava Siegfried, Rotem Karni
Publicado en: Trends in Cancer, Edición 11, 2025, ISSN 2405-8033
Editor: Elsevier BV
DOI: 10.1016/J.TRECAN.2024.10.008

Non-Coding RNA in Tumor Cells and Tumor-Associated Myeloid Cells—Function and Therapeutic Potential

Autores: Amanda Katharina Binder, Franziska Bremm, Jan Dörrie, Niels Schaft
Publicado en: International Journal of Molecular Sciences, Edición 25, 2025, ISSN 1422-0067
Editor: MDPI AG
DOI: 10.3390/IJMS25137275

RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer

Autores: Amina Jbara, Kuan-Ting Lin, Chani Stossel, Zahava Siegfried, Haya Shqerat, Adi Amar-Schwartz, Ela Elyada, Maxim Mogilevsky, Maria Raitses-Gurevich, Jared L. Johnson, Tomer M. Yaron, Ofek Ovadia, Gun Ho Jang, Miri Danan-Gotthold, Lewis C. Cantley, Erez Y. Levanon, Steven Gallinger, Adrian R. Krainer, Talia Golan, Rotem Karni
Publicado en: Nature, Edición 617, 2023, ISSN 0028-0836
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41586-023-05820-3

Apolipoprotein E4 facilitates transfection of human monocyte-derived dendritic cells by lipid nanoparticles

Autores: Izabella Lambart, Hannah Zaryouh, Jonas Van Audenaerde, Dana Liu, Delphine Quatannens, Eva Lion, Stefan Schiller, Simon Geissler, Evelien Smits, Karsten Mäder
Publicado en: International Journal of Pharmaceutics, Edición 678, 2025, ISSN 0378-5173
Editor: Elsevier BV
DOI: 10.1016/J.IJPHARM.2025.125720

Precise in vivo RNA base editing with a wobble-enhanced circular CLUSTER guide RNA

Autores: Philipp Reautschnig, Carolin Fruhner, Nicolai Wahn, Charlotte P. Wiegand, Sabrina Kragness, John F. Yung, Daniel T. Hofacker, Jenna Fisk, Michelle Eidelman, Nils Waffenschmidt, Maximilian Feige, Laura S. Pfeiffer, Annika E. Schulz, Yvonne Füll, Erez Y. Levanon, Gail Mandel, Thorsten Stafforst
Publicado en: Nature Biotechnology, Edición 43, 2025, ISSN 1087-0156
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41587-024-02313-0

Melanoma 2.0. Skin cancer as a paradigm for emerging diagnostic technologies, computational modelling and artificial intelligence

Autores: Julio Vera, Xin Lai, Andreas Baur, Michael Erdmann, Shailendra Gupta, Cristiano Guttà, Lucie Heinzerling, Markus V Heppt, Philipp Maximilian Kazmierczak, Manfred Kunz, Christopher Lischer, Brigitte M Pützer, Markus Rehm, Christian Ostalecki, Jimmy Retzlaff, Stephan Witt, Olaf Wolkenhauer, Carola Berking
Publicado en: Briefings in Bioinformatics, Edición 23, 2022, ISSN 1467-5463
Editor: Oxford University Press (OUP)
DOI: 10.1093/BIB/BBAC433

The Influence of Indisulam on Human Immune Effector Cells: Is a Combination with Immunotherapy Feasible?

Autores: Lisa Arnet, Lisabeth Emilius, Annett Hamann, Maria Carmo-Fonseca, Carola Berking, Jan Dörrie, Niels Schaft
Publicado en: Pharmaceutics, Edición 17, 2025, ISSN 1999-4923
Editor: MDPI AG
DOI: 10.3390/PHARMACEUTICS17030368

Alternative splicing of modulatory immune receptors in T lymphocytes: a newly identified and targetable mechanism for anticancer immunotherapy

Autores: Shay Tzaban, Ori Stern, Elad Zisman, Galit Eisenberg, Shiri Klein, Shoshana Frankenburg, Michal Lotem
Publicado en: Frontiers in Immunology, Edición 15, 2025, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/FIMMU.2024.1490035

Unveiling alternative splicing dynamics in activated T lymphocytes and their implications for immune checkpoint blockade efficacy

Autores: Elad Zisman, Ori Stern, Reyut Lewis, Shay Tzaban 1, Thomas Eisenhaure, Sarah E Henrickson, Moshe Sade-Feldman, Shira Silberman-Klein, Galit Eisenberg, Nir Hacohen, Keren Yizhak, Michal Lotem
Publicado en: iScience, 2025, ISSN 2589-0042
Editor: Cell Press
DOI: 10.1016/J.ISCI.2025

Transcriptome-wide splicing network reveals specialized regulatory functions of the core spliceosome

Autores: Malgorzata E. Rogalska, Estefania Mancini, Sophie Bonnal, André Gohr, Bryan M. Dunyak, Niccolò Arecco, Peter G. Smith, Frédéric H. Vaillancourt, Juan Valcárcel
Publicado en: Science, Edición 386, 2024, ISSN 0036-8075
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIENCE.ADN8105

Conference proceedings (1)

Human Gene Therapy

Autores: S. Tzaban, P. Appasamy, E. Abdallah, R. Lewis, E. Zisman, S. Klein, R. Karni, G. Eisenberg, M. Lotem
Publicado en: International Conference on Lymphocyte Engineering, Edición 4, 2023, ISSN 1043-0342
Editor: Human Gene Therapy
DOI: 10.1089/hum.2023.29253.abstracts.index