RNA PROCESSING FOR ANTI-CANCER IMMUNOTHERAPY

Informacje na temat projektu

CANCERNA

Identyfikator umowy o grant: 101057250

DOI

10.3030/101057250

Projekt został zamknięty

Data podpisania przez KE 19 Maja 2022

Data rozpoczęcia 1 Czerwca 2022

Data zakończenia 31 Maja 2025

Finansowanie w ramach

• Health

Koszt całkowity

€ 5 999 381,25

Wkład UE

€ 5 999 381,00

Koordynowany przez

HADASSAH MEDICAL ORGANIZATION
Israel

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Data sets, microdata, etc (2)

List of altered transcripts and NMD-prone transcripts

a. List of altered transcripts, which are induced by the presence of splicing factor mutations and generate predicted immunogenic peptides (M18)b.List of NMD-prone transcripts which are induced by the presence of NMD inhibitors generate predicted immunogenic peptides (M18)

Bio-bank of tumour samples and generation of RNA-seq datasets

a. Bio-bank of tumour samples (uveal melanoma and MDS/AML) harbouring mutations in splicing factor genes (M12)b.Generation of RNA-seq datasets and splicing analysis of tumour samples (uveal melanoma and MDS/AML) harbouring mutations in splicing factor genes (M18)

Websites, patent fillings, videos etc. (1)

CANCERNA project website and social media platforms

Other (1)

Selection of a reproducible method to be adopted by participating groups, of mRNA-loaded APC preparation for vaccine epitope presentation.

Publikacje

Peer reviewed articles (16)

The future of affordable cancer immunotherapy

Autorzy: Schaft N, Dörrie J, Schuler G, Schuler-Thurner B, Sallam H, Klein S, Eisenberg G, Frankenburg S, Lotem M, Khatib A.
Opublikowane w: Frontiers in Immunology, Numer 1248867, 2023, ISSN 1664-3224
Wydawca: Frontiers Media SA
DOI: 10.3389/fimmu.2023.1248867

Tumor Antigens beyond the Human Exome

Autorzy: Lisabeth Emilius, Franziska Bremm, Amanda Katharina Binder, Niels Schaft, Jan Dörrie
Opublikowane w: International Journal of Molecular Sciences, Numer 25, 2025, ISSN 1422-0067
Wydawca: MDPI AG
DOI: 10.3390/IJMS25094673

Cancers

Autorzy: S. Matos, P. Bernardo, S. Esteves, A.B.d. Sousa, M. Lemos, P. Ribeiro, M. Silva, A. Nunes, J. Lobato, M.d.J. Frade, M.G.da. S, S. Chacim, J. Mariz, G. Esteves,J. Raposo, A. Espadana, J. Carda, P. Barbosa, V. Martins, M. Carmo-Fonseca, J. Desterro
Opublikowane w: Cancers, Numer 14133236, 2022, ISSN 2072-6694
Wydawca: MDPI
DOI: 10.3390/cancers14133236

Spliced to kill: RNA mis-splicing derived cancer neoantigens

Autorzy: Anurag V. Prabhu, Carla Azar-Koussa, Zahava Siegfried, Rotem Karni
Opublikowane w: Trends in Cancer, 2025, ISSN 2405-8033
Wydawca: Elsevier BV
DOI: 10.1016/J.TRECAN.2025.06.001

Targeting splicing factors for cancer therapy

Autorzy: Ariel Bashari, Zahava Siegfried, Rotem Karni
Opublikowane w: RNA, Numer 29, 2023, ISSN 1355-8382
Wydawca: Cold Spring Harbor Laboratory
DOI: 10.1261/RNA.079585.123

Gene network-based and ensemble modeling-based selection of tumor-associated antigens with a predicted low risk of tissue damage for targeted immunotherapy

Autorzy: Christopher Lischer, Martin Eberhardt, Cindy Flamann, Johannes Berges, Esther Güse, Anja Wessely, Adrian Weich, Jimmy Retzlaff, Jan Dörrie, Niels Schaft, Manuel Wiesinger, Johannes März, Beatrice Schuler-Thurner, Harald Knorr, Shailendra Gupta, Krishna Pal Singh, Gerold Schuler, Markus Vincent Heppt, Elias Andreas Thomas Koch, Nadine D van Kleef, Julian J Freen-van Heeren, Annelies W Turksma, Olaf Wolkenhauer, Bettina Hohberger, Carola Berking, Heiko Bruns, Julio Vera
Opublikowane w: Journal for ImmunoTherapy of Cancer, Numer 12, 2024, ISSN 2051-1426
Wydawca: BMJ
DOI: 10.1136/JITC-2023-008104

Generation of tumor neoantigens by RNA splicing perturbation

Autorzy: Adi Rosenberg-Mogilevsky, Zahava Siegfried, Rotem Karni
Opublikowane w: Trends in Cancer, Numer 11, 2025, ISSN 2405-8033
Wydawca: Elsevier BV
DOI: 10.1016/J.TRECAN.2024.10.008

Non-Coding RNA in Tumor Cells and Tumor-Associated Myeloid Cells—Function and Therapeutic Potential

Autorzy: Amanda Katharina Binder, Franziska Bremm, Jan Dörrie, Niels Schaft
Opublikowane w: International Journal of Molecular Sciences, Numer 25, 2025, ISSN 1422-0067
Wydawca: MDPI AG
DOI: 10.3390/IJMS25137275

RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer

Autorzy: Amina Jbara, Kuan-Ting Lin, Chani Stossel, Zahava Siegfried, Haya Shqerat, Adi Amar-Schwartz, Ela Elyada, Maxim Mogilevsky, Maria Raitses-Gurevich, Jared L. Johnson, Tomer M. Yaron, Ofek Ovadia, Gun Ho Jang, Miri Danan-Gotthold, Lewis C. Cantley, Erez Y. Levanon, Steven Gallinger, Adrian R. Krainer, Talia Golan, Rotem Karni
Opublikowane w: Nature, Numer 617, 2023, ISSN 0028-0836
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S41586-023-05820-3

Apolipoprotein E4 facilitates transfection of human monocyte-derived dendritic cells by lipid nanoparticles

Autorzy: Izabella Lambart, Hannah Zaryouh, Jonas Van Audenaerde, Dana Liu, Delphine Quatannens, Eva Lion, Stefan Schiller, Simon Geissler, Evelien Smits, Karsten Mäder
Opublikowane w: International Journal of Pharmaceutics, Numer 678, 2025, ISSN 0378-5173
Wydawca: Elsevier BV
DOI: 10.1016/J.IJPHARM.2025.125720

Precise in vivo RNA base editing with a wobble-enhanced circular CLUSTER guide RNA

Autorzy: Philipp Reautschnig, Carolin Fruhner, Nicolai Wahn, Charlotte P. Wiegand, Sabrina Kragness, John F. Yung, Daniel T. Hofacker, Jenna Fisk, Michelle Eidelman, Nils Waffenschmidt, Maximilian Feige, Laura S. Pfeiffer, Annika E. Schulz, Yvonne Füll, Erez Y. Levanon, Gail Mandel, Thorsten Stafforst
Opublikowane w: Nature Biotechnology, Numer 43, 2025, ISSN 1087-0156
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S41587-024-02313-0

Melanoma 2.0. Skin cancer as a paradigm for emerging diagnostic technologies, computational modelling and artificial intelligence

Autorzy: Julio Vera, Xin Lai, Andreas Baur, Michael Erdmann, Shailendra Gupta, Cristiano Guttà, Lucie Heinzerling, Markus V Heppt, Philipp Maximilian Kazmierczak, Manfred Kunz, Christopher Lischer, Brigitte M Pützer, Markus Rehm, Christian Ostalecki, Jimmy Retzlaff, Stephan Witt, Olaf Wolkenhauer, Carola Berking
Opublikowane w: Briefings in Bioinformatics, Numer 23, 2022, ISSN 1467-5463
Wydawca: Oxford University Press (OUP)
DOI: 10.1093/BIB/BBAC433

The Influence of Indisulam on Human Immune Effector Cells: Is a Combination with Immunotherapy Feasible?

Autorzy: Lisa Arnet, Lisabeth Emilius, Annett Hamann, Maria Carmo-Fonseca, Carola Berking, Jan Dörrie, Niels Schaft
Opublikowane w: Pharmaceutics, Numer 17, 2025, ISSN 1999-4923
Wydawca: MDPI AG
DOI: 10.3390/PHARMACEUTICS17030368

Alternative splicing of modulatory immune receptors in T lymphocytes: a newly identified and targetable mechanism for anticancer immunotherapy

Autorzy: Shay Tzaban, Ori Stern, Elad Zisman, Galit Eisenberg, Shiri Klein, Shoshana Frankenburg, Michal Lotem
Opublikowane w: Frontiers in Immunology, Numer 15, 2025, ISSN 1664-3224
Wydawca: Frontiers Media SA
DOI: 10.3389/FIMMU.2024.1490035

Unveiling alternative splicing dynamics in activated T lymphocytes and their implications for immune checkpoint blockade efficacy

Autorzy: Elad Zisman, Ori Stern, Reyut Lewis, Shay Tzaban 1, Thomas Eisenhaure, Sarah E Henrickson, Moshe Sade-Feldman, Shira Silberman-Klein, Galit Eisenberg, Nir Hacohen, Keren Yizhak, Michal Lotem
Opublikowane w: iScience, 2025, ISSN 2589-0042
Wydawca: Cell Press
DOI: 10.1016/J.ISCI.2025

Transcriptome-wide splicing network reveals specialized regulatory functions of the core spliceosome

Autorzy: Malgorzata E. Rogalska, Estefania Mancini, Sophie Bonnal, André Gohr, Bryan M. Dunyak, Niccolò Arecco, Peter G. Smith, Frédéric H. Vaillancourt, Juan Valcárcel
Opublikowane w: Science, Numer 386, 2024, ISSN 0036-8075
Wydawca: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIENCE.ADN8105

Conference proceedings (1)

Human Gene Therapy

Autorzy: S. Tzaban, P. Appasamy, E. Abdallah, R. Lewis, E. Zisman, S. Klein, R. Karni, G. Eisenberg, M. Lotem
Opublikowane w: International Conference on Lymphocyte Engineering, Numer 4, 2023, ISSN 1043-0342
Wydawca: Human Gene Therapy
DOI: 10.1089/hum.2023.29253.abstracts.index