Boosting the reduction of the environmental impact of pharmaceutical products throughout their entire life cycle.

Projektinformationen

ETERNAL

ID Finanzhilfevereinbarung: 101057668

DOI

10.3030/101057668

EK-Unterschriftsdatum 23 Mai 2022

Startdatum 1 September 2022

Enddatum 31 August 2026

Finanziert unter

• Health

Gesamtkosten

€ 5 922 398,75

EU-Beitrag

€ 5 922 396,00

Koordiniert durch

AIMPLAS - ASOCIACION DE INVESTIGACION DE MATERIALES PLASTICOS Y CONEXAS
Spain

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Documents, reports (8)

Report on the standardization landscape and applicable standards

Report summarizing the relevant standardization landscape and appliable standards

Roadmap for adoption of PAT and Digital Twin Technologies (including regulatory compliance requirements)

Report that will consist in a summary review of SoA of PAT and Digital Twin adoption in European Pharmaceutical industry; a SWOT analysis to feed into an Opportunities Roadmap that also takes account of the regulatory hurdles, as well as recommendations for a favorable/enabling regulatory framework, without compromising safety.

Report on cooperation with the EC's JRC

Public report that documents the work performed in cooperation with the EC’s JRC in the field of new approach methodologies for ecotoxicity assessment and the outcomes.

Report on exposure and ecotoxicological gap filling: targeted modelling and experimental studies, mode of action catalogue

Public report on exposure and ecotoxicological gap filling: targeted modelling and experimental studies, mode of action catalogue.

"Concept paper on ""compliance-by-design"" key-drivers and roadmap of the possible regulatory pathways or relevant regulatory frameworks for the required ""compliance-by-design"" strategies"

Concept paper that reviews the latest developments in the scientific review, regulation, and marketing authorization procedures in the respective fields (related to the ETERNAL technological processes and developments) to inform a ‘compliant-by-design’ strategy in relation to the developments as part of the ETERNAL cocreation process.

First Updated of Report on the contribution to standardization

First updated of Report outlining the contribution the project has/will make to standards.

Report on the contribution to standardization

Report outlining the contribution the project has/will make to standards.

Research roadmap and inventory of tools for the integration of existing knowledge into pharma risk assessment

Public report that documents a research roadmap for the integration of scientific and regulatory knowledge into pharmaceutical risk assessment for fate modelling, bioavailability assessment and receptor identification, for regulatory testing and assessment, and inventory of tools for the integration of existing knowledge into pharma risk assessment.

Websites, patent fillings, videos etc. (1)

Project website

Project website.

Veröffentlichungen

Peer reviewed articles (6)

A framework for early-stage sustainability assessment of innovation projects enabled by weighted sum multi-criteria decision analysis in the presence of uncertainty

Autoren: John Henderson; Robert Peeling
Veröffentlicht in: Open Research Europe, 2024, ISSN 2732-5121
Herausgeber: Open Research Europe
DOI: 10.12688/OPENRESEUROPE.18195.1

Recovery and reuse of homogeneous palladium catalysts <i>via</i> organic solvent nanofiltration: application in the synthesis of AZD4625

Autoren: Hui Xiao; William R. F. Goundry; Rhys Griffiths; Yanyue Feng; Staffan Karlsson
Veröffentlicht in: Green Chemistry, 2025, ISSN 1463-9270
Herausgeber: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4GC06334A

Environmental Toxicology

Autoren: Fábio Campos; Maria D. Pavlaki; Amadeu M. V. M. Soares; Susana Loureiro
Veröffentlicht in: Environmental Toxicology, 2025, ISSN 1520-4081
Herausgeber: John Wiley & Sons Inc.
DOI: 10.1002/TOX.70002

Laccase‑Mediated Transformation of Trazodone Hydrochloride and Its By‑Products

Autoren: Fabbri, F., Warne, C. M., Cassatella, P., Ruso, D., Doppler, M., Pellis, A., & Guebitz, G. M. (2025).
Veröffentlicht in: Reactions in Chemistry, ISSN 0000-0000
Herausgeber: Scilight Press
DOI: 10.37819/RC.2508001073

Continuous improvement towards environmental protection for pharmaceuticals: advancing a strategy for Europe

Autoren: Sam Harrison, Catherine Barnett, Stephen Short, Cansu Uluseker, Patricia V. Silva, Maria D. Pavlaki, Sarah Roberts, Madalena Vieira, Stephen Lofts, Susana Loureiro, David J. Spurgeon
Veröffentlicht in: Environmental Sciences Europe, Ausgabe 37, 2025, ISSN 2190-4715
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1186/S12302-025-01180-Z

Organic Solvent Nanofiltration in Pharmaceutical Applications

Autoren: Xiaoa, Hui; Feng, Yanyue; Goundry, William R.F.; Karlsson, Staffan
Veröffentlicht in: Organic Process Research and Development, 2024, ISSN 0000-0000
Herausgeber: American Chemical Society
DOI: 10.1021/acs.oprd.3c00470

Conference proceedings (7)

Project Eternal Overview Presentation

Autoren: Ferrer Pérez, Pablo; Sebastia-Luna, Paz; Henderson, John
Veröffentlicht in: 2025
Herausgeber: ZENODO
DOI: 10.5281/ZENODO.10688671

Workshop Output report from an ETERNAL Industry engagement workshop at Making Pharmaceuticals UK Conference programme. Making Pharmaceuticals UK Conference, Coventry, United Kingdom.

Autoren: Henderson, J.
Veröffentlicht in: Zenodo, 2024
Herausgeber: Zenodo
DOI: 10.5281/ZENODO.12745018

SETAC_Pharmaceuticals Strategy for Europe A Call for Continuous Improvement towards Environmental Protection

Autoren: Sam Harrison
Veröffentlicht in: SETAC Europe 34th Annual Meeting (SETAC), Seville, 2025
Herausgeber: SPRINGER
DOI: 10.1186/s12302-025-01180-z

Integrating Artificial Intelligence and Big Data in Pharmaceutical Development: Ethical Considerations and Legislative Frameworks.

Autoren: Pedraza, D. H., Nettleton, D., Poch, A., & López de la Cruz, M. (2024).
Veröffentlicht in: Zenodo
Herausgeber: Zenodo
DOI: 10.5281/ZENODO.11572746

Assessing the feasibility of Twin Screw Extrusion processing in the development of pharmaceutical products

Autoren: Ficiarà, E.
Veröffentlicht in: 2024
Herausgeber: Zenodo
DOI: 10.5281/ZENODO.15114844

A New Collaboration to Establish Safe and Sustainable Pharmaceutical Lifecycles by Design

Autoren: Henderson, John; Peeling Robert
Veröffentlicht in: 2025
DOI: 10.5281/zenodo.10788903

Optimized used of solvents in Active Pharmaceutical Ingredients production

Autoren: Iacoangeli, T.
Veröffentlicht in: 2024
Herausgeber: Zenodo
DOI: 10.5281/ZENODO.15114540

Other (1)

"Concept paper on ""compliant-by-design"" key-drivers and roadmap of the possible regulatory pathways or relevant regulatory frameworks for the required ""compliant-by-design"" strategies"

Autoren: Diego Hernandez Pedraza
Veröffentlicht in: 2023
Herausgeber: 00000
DOI: 10.5281/ZENODO.12795163