Transforming into a sustainable European pharmaceutical sector

Projektinformationen

TransPharm

ID Finanzhilfevereinbarung: 101057816

DOI

10.3030/101057816

EK-Unterschriftsdatum 19 Mai 2022

Startdatum 1 Juni 2022

Enddatum 31 Mai 2026

Finanziert unter

• Health

Gesamtkosten

€ 8 077 100,74

EU-Beitrag

€ 8 039 600,24

Koordiniert durch

UNIVERSITEIT GENT
Belgium

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Websites, patent fillings, videos etc. (3)

Plan for Stakeholder Engagement

Initial report on stakeholder needs and interests related to TransPharm project.

Plan for Dissemination, Communication and Exploitation of Results

PSEDER will include (i) mapping of stakeholders / specific target groups; (ii) key exploitation / dissemination opportunities per target group; (iii) definition of project communication strategy; (iv) measures and activities for reaching each target group, with a time plan for implementation; (v) measurable control points and activities’ assessment; (vi) dissemination database with stakeholders at national/European level.

Project website

Setup project website to be updated regularly with outcomes of WP1, WP2, WP3, WP4, WP5 and WP6.

Documents, reports (4)

Report on stakeholder needs and interests related to TransPharm tools/methods

Report on stakeholder needs and interests related to TransPharm tools/methodsThe report summarises stakeholder requirements identified in interviews / online survey, and matches them with an overview of TransPharm tools/methods, including a first specification of which requirements could be more easily incorporated in them and which are more challenging.

Stakeholder views, needs & wishes on sustainability assessment of APIs

The report provides an overview of stakeholder views, needs and wishes in relation to the sustainability assessment of pharmaceuticals, based on interviews, surveys and/or focus groups, as well as their views regarding the draft assessment approach, the draft value chain map and potential trade-offs.

Methodologies to fill LCI data gaps for prospective and retrospective assessments

Lessons learned on methodologies to fill LCI data gaps for prospective and retrospective assessments will be described as input for the case studies (project internal documents on the project sharepoint) and as input for the guidance on integrated sustainability assessment of pharaceuticals (D4.5, integral general text and appendix for technical details).

Guidelines for reduction of nitrosamine and transition metal contamination in pharmaceuticals

Research-based recommendations for reducing N-nitrosamine impurities and transition metal contamination in synthetic active pharmaceutical ingredients.

Data sets, microdata, etc (1)

Databases used for training the models, accessible in excel format or through a web tool

Well-curated databases using canonical SMILES and InChI to as unique molecular identifiers. For reactions, reaction SMILES or SMIRKS will be used. The databases will be stored in NoSQL format that can be exported to a user-friendly interface, such as excel.

Veröffentlichungen

Peer reviewed articles (10)

Water brownness regulates the bioavailability of a fluoroquinolone antibiotic: UV-absorbance as a predictor of ciprofloxacin ecotoxicity

Autoren: Qiyun Zhanga, Kristof Demeestere, Karel A.C. De Schamphelaere
Veröffentlicht in: Environmental Pollution, Ausgabe 334, 2023, ISSN 1873-6424
Herausgeber: ScienceDirect
DOI: 10.1016/j.envpol.2023.122209

Eco-pharma dilemma: Navigating environmental sustainability trade-offs within the lifecycle of pharmaceuticals – A comment

Autoren: Caroline T.A. Moermond, Neele Puhlmann, Lowik Pieters, Avtar Matharu, Lieselot Boone, Maarten Dobbelaere, Héloïse Proquin, Klaus Kümmerer, Ad M.J. Ragas, Rodrigo Vidaurre, Bastiaan Venhuis, Delphine De Smedt
Veröffentlicht in: Sustainable Chemistry and Pharmacy, Ausgabe 43, 2025, ISSN 2352-5541
Herausgeber: Elsevier BV
DOI: 10.1016/J.SCP.2024.101893

Scalable synthesis of 3-O functionalized deoxyribonolactones from biorenewable levoglucosenone

Autoren: Maarten Debruyne, Martha C. Mayorquín-Torres, Jason E. Camp, Christian V. Stevens
Veröffentlicht in: Arkivoc, Ausgabe 2024, 2025, ISSN 1551-7012
Herausgeber: ARKAT USA, Inc.
DOI: 10.24820/ARK.5550190.P012.378

Tandem Cu(I)-Catalyzed Dipolar Cycloaddition–C–H Activation for the In-Flow Synthesis of <i>N</i>-Pyridyl-5-amino-1,2,3-triazole-4-carboxylates

Autoren: Emanuela Donato, Martha C. Mayorquín-Torres, Alessandra Puglisi, Maurizio Benaglia, Mauro F. A. Adamo, Christian V. Stevens
Veröffentlicht in: Organic Letters, Ausgabe 27, 2025, ISSN 1523-7060
Herausgeber: American Chemical Society (ACS)
DOI: 10.1021/ACS.ORGLETT.5C00453

Geometric deep learning for molecular property predictions with chemical accuracy across chemical space

Autoren: Maarten R. Dobbelaere, István Lengyel, Christian V. Stevens, Kevin M. Van Geem
Veröffentlicht in: Journal of Cheminformatics, Ausgabe 16, 2024, ISSN 1758-2946
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1186/S13321-024-00895-0

Mapping the risk of ciprofloxacin in European water bodies: Incorporating the impact of bioavailability

Autoren: Qiyun Zhang, Kristof Demeestere, Karel A.C. De Schamphelaere
Veröffentlicht in: Science of The Total Environment, Ausgabe 955, 2025, ISSN 0048-9697
Herausgeber: Elsevier BV
DOI: 10.1016/J.SCITOTENV.2024.177202

Rxn-INSIGHT: fast chemical reaction analysis using bond-electron matrices

Autoren: Maarten R. Dobbelaere, István Lengyel, Christian V. Stevens, Kevin M. Van Geem
Veröffentlicht in: Journal of Cheminformatics, Ausgabe 16, 2024, ISSN 1758-2946
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1186/S13321-024-00834-Z

Applicability of the European Commission’s framework on safe and sustainable by design to the pharmaceutical sector

Autoren: Neele Puhlmann, Elisabetta Abbate, Klaus Kümmerer, Agnes G. Oomen, Ad M.J. Ragas, Caroline Moermond
Veröffentlicht in: Sustainable Chemistry and Pharmacy, Ausgabe 42, 2024, ISSN 2352-5541
Herausgeber: Elsevier BV
DOI: 10.1016/J.SCP.2024.101845

A holistic framework for integrated sustainability assessment of pharmaceuticals

Autoren: Lisa Van Wilder, Lieselot Boone, Ad Ragas, Caroline Moermond, Lowik Pieters, Aissa Rechlin, Rodrigo Vidaurre, Delphine De Smedt, Jo Dewulf
Veröffentlicht in: Journal of Cleaner Production, Ausgabe 467, 2024, ISSN 0959-6526
Herausgeber: Elsevier BV
DOI: 10.1016/J.JCLEPRO.2024.142978

Keystones in the implementation of greener pharmaceuticals: A scoping review

Autoren: Ella D. van Vliet, Nynke M. Kannegieter, Caroline T.A. Moermond, Teresa Leonardo Alves
Veröffentlicht in: Sustainable Chemistry and Pharmacy, Ausgabe 44, 2025, ISSN 2352-5541
Herausgeber: Elsevier BV
DOI: 10.1016/J.SCP.2025.101938