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CORDIS - Risultati della ricerca dell’UE
CORDIS

Transforming into a sustainable European pharmaceutical sector

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Plan for Stakeholder Engagement (si apre in una nuova finestra)

Initial report on stakeholder needs and interests related to TransPharm project.

Plan for Dissemination, Communication and Exploitation of Results (si apre in una nuova finestra)

PSEDER will include (i) mapping of stakeholders / specific target groups; (ii) key exploitation / dissemination opportunities per target group; (iii) definition of project communication strategy; (iv) measures and activities for reaching each target group, with a time plan for implementation; (v) measurable control points and activities’ assessment; (vi) dissemination database with stakeholders at national/European level.

Project website (si apre in una nuova finestra)

Setup project website to be updated regularly with outcomes of WP1, WP2, WP3, WP4, WP5 and WP6.

Report on stakeholder needs and interests related to TransPharm tools/methods (si apre in una nuova finestra)

Report on stakeholder needs and interests related to TransPharm tools/methodsThe report summarises stakeholder requirements identified in interviews / online survey, and matches them with an overview of TransPharm tools/methods, including a first specification of which requirements could be more easily incorporated in them and which are more challenging.

Stakeholder views, needs & wishes on sustainability assessment of APIs (si apre in una nuova finestra)

The report provides an overview of stakeholder views, needs and wishes in relation to the sustainability assessment of pharmaceuticals, based on interviews, surveys and/or focus groups, as well as their views regarding the draft assessment approach, the draft value chain map and potential trade-offs.

Methodologies to fill LCI data gaps for prospective and retrospective assessments (si apre in una nuova finestra)

Lessons learned on methodologies to fill LCI data gaps for prospective and retrospective assessments will be described as input for the case studies (project internal documents on the project sharepoint) and as input for the guidance on integrated sustainability assessment of pharaceuticals (D4.5, integral general text and appendix for technical details).

Guidelines for reduction of nitrosamine and transition metal contamination in pharmaceuticals (si apre in una nuova finestra)

Research-based recommendations for reducing N-nitrosamine impurities and transition metal contamination in synthetic active pharmaceutical ingredients.

Databases used for training the models, accessible in excel format or through a web tool (si apre in una nuova finestra)

Well-curated databases using canonical SMILES and InChI to as unique molecular identifiers. For reactions, reaction SMILES or SMIRKS will be used. The databases will be stored in NoSQL format that can be exported to a user-friendly interface, such as excel.

Pubblicazioni

Water brownness regulates the bioavailability of a fluoroquinolone antibiotic: UV-absorbance as a predictor of ciprofloxacin ecotoxicity (si apre in una nuova finestra)

Autori: Qiyun Zhanga, Kristof Demeestere, Karel A.C. De Schamphelaere
Pubblicato in: Environmental Pollution, Numero 334, 2023, ISSN 1873-6424
Editore: ScienceDirect
DOI: 10.1016/j.envpol.2023.122209

Eco-pharma dilemma: Navigating environmental sustainability trade-offs within the lifecycle of pharmaceuticals – A comment (si apre in una nuova finestra)

Autori: Caroline T.A. Moermond, Neele Puhlmann, Lowik Pieters, Avtar Matharu, Lieselot Boone, Maarten Dobbelaere, Héloïse Proquin, Klaus Kümmerer, Ad M.J. Ragas, Rodrigo Vidaurre, Bastiaan Venhuis, Delphine De Smedt
Pubblicato in: Sustainable Chemistry and Pharmacy, Numero 43, 2025, ISSN 2352-5541
Editore: Elsevier BV
DOI: 10.1016/J.SCP.2024.101893

Scalable synthesis of 3-O functionalized deoxyribonolactones from biorenewable levoglucosenone (si apre in una nuova finestra)

Autori: Maarten Debruyne, Martha C. Mayorquín-Torres, Jason E. Camp, Christian V. Stevens
Pubblicato in: Arkivoc, Numero 2024, 2025, ISSN 1551-7012
Editore: ARKAT USA, Inc.
DOI: 10.24820/ARK.5550190.P012.378

Tandem Cu(I)-Catalyzed Dipolar Cycloaddition–C–H Activation for the In-Flow Synthesis of <i>N</i>-Pyridyl-5-amino-1,2,3-triazole-4-carboxylates (si apre in una nuova finestra)

Autori: Emanuela Donato, Martha C. Mayorquín-Torres, Alessandra Puglisi, Maurizio Benaglia, Mauro F. A. Adamo, Christian V. Stevens
Pubblicato in: Organic Letters, Numero 27, 2025, ISSN 1523-7060
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.ORGLETT.5C00453

Geometric deep learning for molecular property predictions with chemical accuracy across chemical space (si apre in una nuova finestra)

Autori: Maarten R. Dobbelaere, István Lengyel, Christian V. Stevens, Kevin M. Van Geem
Pubblicato in: Journal of Cheminformatics, Numero 16, 2024, ISSN 1758-2946
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S13321-024-00895-0

Mapping the risk of ciprofloxacin in European water bodies: Incorporating the impact of bioavailability (si apre in una nuova finestra)

Autori: Qiyun Zhang, Kristof Demeestere, Karel A.C. De Schamphelaere
Pubblicato in: Science of The Total Environment, Numero 955, 2025, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/J.SCITOTENV.2024.177202

Rxn-INSIGHT: fast chemical reaction analysis using bond-electron matrices (si apre in una nuova finestra)

Autori: Maarten R. Dobbelaere, István Lengyel, Christian V. Stevens, Kevin M. Van Geem
Pubblicato in: Journal of Cheminformatics, Numero 16, 2024, ISSN 1758-2946
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S13321-024-00834-Z

Applicability of the European Commission’s framework on safe and sustainable by design to the pharmaceutical sector (si apre in una nuova finestra)

Autori: Neele Puhlmann, Elisabetta Abbate, Klaus Kümmerer, Agnes G. Oomen, Ad M.J. Ragas, Caroline Moermond
Pubblicato in: Sustainable Chemistry and Pharmacy, Numero 42, 2024, ISSN 2352-5541
Editore: Elsevier BV
DOI: 10.1016/J.SCP.2024.101845

A holistic framework for integrated sustainability assessment of pharmaceuticals (si apre in una nuova finestra)

Autori: Lisa Van Wilder, Lieselot Boone, Ad Ragas, Caroline Moermond, Lowik Pieters, Aissa Rechlin, Rodrigo Vidaurre, Delphine De Smedt, Jo Dewulf
Pubblicato in: Journal of Cleaner Production, Numero 467, 2024, ISSN 0959-6526
Editore: Elsevier BV
DOI: 10.1016/J.JCLEPRO.2024.142978

Keystones in the implementation of greener pharmaceuticals: A scoping review (si apre in una nuova finestra)

Autori: Ella D. van Vliet, Nynke M. Kannegieter, Caroline T.A. Moermond, Teresa Leonardo Alves
Pubblicato in: Sustainable Chemistry and Pharmacy, Numero 44, 2025, ISSN 2352-5541
Editore: Elsevier BV
DOI: 10.1016/J.SCP.2025.101938

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