Skip to main content
European Commission logo
polski polski
CORDIS - Wyniki badań wspieranych przez UE
CORDIS

Metal-containing Radical Enzymes

Cel

The pharmaceutical, chemical and polymer industries are cornerstones of Europe’s economy. A key element for their
transition to more sustainable processes and to innovative new compounds is biocatalysis.
Of particular interest are metallo-enzymes, i.e. proteins that host a metal cofactor. They catalyze a multitude of redox and
radical reactions. To access reactions that are unknown in nature, artificial metallo-enzymes can be created. They combine
the new-to-nature catalytic activity of metal complexes with the selectivity-inducing environment of the active protein site.
To develop novel biocatalysts, a highly interdisciplinary skill set is needed. MetRaZymes will create a PhD school across
leading European universities that will train the next generation of scientists capable of tackling the design, development and
implementation of novel enzymatic reactions in a holistic approach. It brings together computational bioscientists,
bioinorganic and polymer chemists, and bioprocess engineers. Using artificial and repurposed metalloenzymes as the focal
point, the ESRs will develop novel biocatalysts for radical reactions of high synthetic value, such as the late stage
modification of pharmaceutical intermediates or the synthesis of polymers from renewable monomers. To train the ESRs in
the needs of industrial biotechnology, the consortium includes eight of Europe´s leading pharmaceutical, chemical and
enzymology companies. The ESRs will benefit from a vast transferable skills training program delivered by five training
partners. Highlights include a Nature Masterclass and Wikipedia workshop. Communication partners such as Wikimedia and
the Industrial Biotechnology Innovation Centre will act as muliplicators for the communication of results. Moreover, the ESRs
will work with artist that use biology as their way of expression to create an ARTzymes exhibition that will foster the ERS´s
creativity and result in a an unique form of science dialogue with the general public.

Koordynator

TECHNISCHE UNIVERSITAT DARMSTADT
Wkład UE netto
€ 434 232,00
Adres
KAROLINENPLATZ 5
64289 Darmstadt
Niemcy

Zobacz na mapie

Region
Hessen Darmstadt Darmstadt, Kreisfreie Stadt
Rodzaj działalności
Higher or Secondary Education Establishments
Linki
Koszt całkowity
Brak danych

Uczestnicy (6)

Partnerzy (18)