Descrizione del progetto
Sintesi sostenibile di amminoalcoli mediante cascate enzimatiche
Gli amminoalcoli e i 2-idrossicetoni sono prodotti preziosi per l’industria chimica e farmaceutica, ma la loro sintesi è complessa. Attualmente, questi composti sono spesso prodotti in paesi dove vigono condizioni di lavoro precarie e standard ambientali e di sicurezza non elevati. Un processo innovativo ha già posto le basi per una sintesi sostenibile, utilizzando una reazione enzimatica a due fasi, atomica ed efficiente, per la produzione di amminoalcoli a partire da materiali di partenza poco costosi. Il progetto SusECAS - DemoPlant, finanziato dal CER, intende portare questa idea di sintesi innovativa al livello di applicazione industriale. Un impianto dimostrativo su scala multi-grammo consentirà di valutare il processo, dimostrandone le potenzialità ecologiche ed economiche. Nel corso del progetto verrà eseguita un’analisi sistematica del mercato e sarà elaborato un piano aziendale per la commercializzazione e l’introduzione sul mercato dei prodotti e della tecnologia.
Obiettivo
The development of more environmentally friendly synthesis methods is urgently needed if humanity wants to maintain an environment worth living in. The establishment of more biocatalytic steps in chemical synthesis is a possible solution, as enzymes and whole cells offer sustainable advantages such as biodegradability, toxicity, high selectivity and much more.
Amino alcohols and 2-hydroxy ketones are valuable compounds with various applications in the chemical and pharmaceutical industry with market prices >1000 €/kg, but challenging synthesis strategies. As a result of synthesis options with disastrous footprints, these molecules are often produced in countries with poor working conditions and significantly lower safety and environmental standards than those accepted in the EU.
The idea of 'SusECAS - DemoPlant' is simple. An innovative economic and ecological competitive process will enable a sustainable production of amino alcohols in Europe. In the ERC Starting Grant project 'LightCas', Prof. Rother laid the base with an atomic and step-efficient enzymatic 2-step reaction for amino alcohols from inexpensive starting materials (<10-100 €/kg). In 'SusECAS' we will take these innovative synthesis ideas to a new level of industrial application. A multi-gram demonstration plant will enable model-based process evaluation, giving us and our customer’s clear indications of the ecological and economic potential. A systematic market analysis will provide an overview of the competitive structure of the overall market, the market volume and the requirements of potential customers. Supported by business angels, commercialization strategies will be evaluated. In 'SusECAS', we will develop a business plan for commercialization and initiate a step-by-step market introduction of our products and technologies.
Campo scientifico
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- natural scienceschemical sciencesorganic chemistryketones
- natural scienceschemical sciencesorganic chemistryalcohols
- social scienceseconomics and businesseconomicssustainable economy
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes
Programma(i)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Argomento(i)
Meccanismo di finanziamento
HORIZON-AG-LS - HORIZON Lump Sum GrantIstituzione ospitante
52428 Julich
Germania