Systemic Endotoxemia as the driver of chronic inflammation - Biomarkers and novel therapeutic targets for Arthritis

Informazioni relative al progetto

ENDOTARGET

ID dell’accordo di sovvenzione: 101095084

DOI

10.3030/101095084

Data della firma CE 15 Novembre 2022

Data di avvio 1 Gennaio 2023

Data di completamento 31 Dicembre 2026

Finanziato da

• Health

Costo totale

€ 6 997 820,00

Contributo UE

€ 6 997 820,00

Coordinato da

HUS-YHTYMA
Finland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (11)

First report on the effects of various LPS types on intestinal epithelium in vitro

Experimental results on the potential of different LPS types to induce proinflammatory or tolerogenic response in enterocytes as well as to compromise or reinforce epithelial integrity by using in vitro cell culture models.

First version of dissemination and communication plan

Outline of Endotarget’s dissemination and communication strategy including planned D&C activities.

Demonstrate impact of local and systemic LPS effect on joint destruction in in vivo OA animal

Experimental results on the influence of LPS on the severity of arthritic disease in a rat model

Project handbook

All relevant project related information for the consortium will be collected in project handbookIt includes general information of agreements project organizational structure communication and dissemination practices internal reviewprocess of deliverables and payments for example

Second version of dissemination and communication plan

Outline of Endotarget’s dissemination and communication strategy including planned D&C activities.

Report on ME and OA/RA risk

The impact on composition of microbiota on intestinal permability and degree of ME will be assessed as well as the impact of aging. The report will describe the results of statistical models to predict key characteristics of microbiota associated with age and risk of ME.

Report on ethics

Provides support for and promotes compliance with ethical standards, guidance to the Human Resources, ensuring that Endtotarget's policies, procedures and practices, reinforce and promote the ethical standards

Risk Management plan

Deliverable will include the processes, tools and procedures that will be used to manage and control those events within the Endotarget project that could have a negative impact. It will expose the proposed risk management approach of the project for managing and controlling all project risks. Deliverable will be updated throughout the project.

EU innovation ecosystem on CI & health-to-disease transition

Map of stakeholders relevant for Endotarget’s outreach and liaising activities related to chronic inflammation and personalised prevention.

Values of free energy to predict the potential binding affinity of a given LPS, drug and compound to a target receptor.

Computational chemistry experimental results on the potential binding of diverse factors (LPS,drugs, proteins, compounds, etc) to a target receptor or protein.

Report on effect of LPS, OMVs and ECVs on on-chip based gut barrier integrity

Experimental results (e.g. TEER values and fluorescence leakiness assay) on acute and chronic effects of LPS, OMVs and ECVs exposure scenarios on gut epithel barrier tighness.

Websites, patent fillings, videos etc. (1)

Data security architecture and interim compliance update

Data security architecture and interim compliance update of Endtotarget’s is to provide a systematic approach to designing a technical security architecture for the information exchange

Data Management Plan (1)

Data Management Plan

Data Management Plan (DMP) of Endotarget’s is to identify the project’s research data and to describe how to make them findable, accessible, interoperable and re-usable (FAIR)

Pubblicazioni

Peer reviewed articles (10)

β Boswellic Acid Blocks Articular Innate Immune Responses: An In Silico and In Vitro Approach to Traditional Medicine

Autori: Eloi Franco-Trepat; Ana Alonso-Pérez; María Guillán-Fresco; Miriam López-Fagúndez; Andrés Pazos-Pérez; Antía Crespo-Golmar; Susana Belén Bravo; Verónica López-López; Alberto Jorge-Mora; José P. Cerón-Carrasco; Ana Lois Iglesias; Rodolfo Gómez
Pubblicato in: Antioxidants, 2023, ISSN 2076-3921
Editore: MDPI
DOI: 10.3390/antiox12020371

The Hepatokine RBP4 Links Metabolic Diseases to Articular Inflammation

Autori: Andrés Pazos-Pérez, María Piñeiro-Ramil, Eloi Franco-Trepat, Ana Alonso-Pérez, María Guillán-Fresco, Antía Crespo-Golmar, Miriam López-Fagúndez, Javier Conde Aranda, Susana Belen Bravo, Alberto Jorge-Mora and Rodolfo Gómez
Pubblicato in: Antioxidants, 2024, ISSN 2076-3921
Editore: MDPI
DOI: 10.3390/antiox13010124

Atherosclerosis

Autori: J. Parantainen, G. Barreto, T.E. Strandberg, N. Mars, K. Nurmi, K.K. Eklund
Pubblicato in: Atherosclerosis, Numero 405, 2025, ISSN 1879-1484
Editore: Elsevier BV
DOI: 10.1016/J.ATHEROSCLEROSIS.2025.119220

Sensor-integrated gut-on-a-chip for monitoring senescence-mediated changes in the intestinal barrier

Autori: Konstanze Brandauer; Alexandra Lorenz; Silvia Schobesberger; Patrick Schuller; Martin Frauenlob; Sarah Spitz; Peter Ertl
Pubblicato in: Lab on a Chip, 2025, ISSN 1473-0189
Editore: Royal Society of Chemistry
DOI: 10.1039/D4LC00896K

Beyond Seasoning—The Role of Herbs and Spices in Rheumatic Diseases

Autori: Charneca, Sofia; Hernando, Ana; Costa-Reis, Patricia; Guerreiro, Catarina Sousa
Pubblicato in: Nutrients, 2023, ISSN 2072-6643
Editore: MDPI
DOI: 10.3390/nu15122812

Formononetin, a Beer Polyphenol with Catabolic Effects on Chondrocytes

Autori: María Guillán-Fresco; Eloi Franco-Trepat; Ana Alonso-Pérez; Alberto Jorge-Mora; Verónica López-López; Andrés Pazos-Pérez; María Piñeiro-Ramil; Rodolfo Gómez
Pubblicato in: Nutrients, 2023, ISSN 2072-6643
Editore: MDPI
DOI: 10.3390/nu15132959

The collagenase-induced osteoarthritis (CIOA) model: Where mechanical damage meets inflammation

Autori: Patrick Weber; Kajetana Bevc; David Fercher; Sami Kauppinen; Shipin Zhang; Maryam Asadikorayem; Lucia Baixauli Marin; Tanqi Zhang; Tuomas Frondelius; Gian Salzmann; Valentino Bruhin; Jakob Hax; Gonçalo Barreto; Mikko A.J. Finnilä; Marcy Zenobi-Wong
Pubblicato in: Osteoarthritis and Cartilage Open, 2024, ISSN 2665-9131
Editore: Elsevier
DOI: 10.3929/ETHZ-B-000705561

Nutrition Journal

Autori: Charneca, Sofia; Hernando, Ana; Almada-Correia, Inês; Polido Pereira, Joaquim; Vieira, Adriana; Sousa, Joana; Almeida, Ana S.; Motta, Carla Motta; Barreto, Gonçalo; Eklund, Kari K.; Alnso‑Pérez, Ana; Gómez, Rodolfo; Cicc, Francesco; Mauro, Daniele; Pinho, Salomé S.; Fonseca, João Eurico; Costa Reis, Patricia; Guerreiro, Catarina Sousa
Pubblicato in: Nutrition Journal, 2025, ISSN 1475-2891
Editore: BMC
DOI: 10.1186/S12937-025-01089-6

Evaluating the role of lipopolysaccharides in the joint: fibronectin as a novel protective mechanism

Autori: Bevc, Kajetana; Zhang, Shipin; Pazos-Perez, Andres; Alonso-Perez, Ana; Fercher, David; Kauppinen, Sami; Frondelius, Tuomas; Bruhin, Valentino; Salzmann, Gian; Rauer, Thomas; Pape, Hans-Christoph; Finnilä, Mikko Arttu Jalmari; Ospelt, Caroline; Gomez, Rodolfo; Eklund, Kari K; Wong, Marcy Zenobi; Barreto, Goncalo
Pubblicato in: RMD Open, 2025, ISSN 2056-5933
Editore: BMJ
DOI: 10.3929/ETHZ-B-000746816

<i>Odoribacter splanchnicus</i> lipooligosaccharide: an uncommon structure with weak immunostimulatory activity

Autori: Marta Tiemblo-Martin, Marcello Mercogliano, Kaisa Hiippala, Luca De Simone Carone, María Asunción Campanero-Rhodes, Maria Masiello, Alessandro Cangiano, Antonio Molinaro, Luigi Paduano, Dolores Solís, Reetta Satokari, Flaviana Di Lorenzo, Alba Silipo
Pubblicato in: Chemical Science, 2025, ISSN 2041-6520
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5SC08335D