Descripción del proyecto
Biomarcadores para el tratamiento de la insuficiencia renal crónica
La insuficiencia renal crónica (IRC o CKD, por sus siglas en inglés) está asociada a una pérdida progresiva de la función renal y provoca, entre otras cosas, hipertensión, diabetes e infecciones renales. Los pacientes responden de forma diferente a los tratamientos disponibles, lo cual indica que es necesario aplicar un plan personalizado para cada caso. Sin embargo, no existen biomarcadores de IRC que puedan utilizarse para establecer un tratamiento óptimo. El equipo del proyecto PRIME-CKD, financiado con fondos europeos, pretende abordar esta limitación mediante el descubrimiento de biomarcadores farmacodinámicos para el tratamiento de la IRC. Además, a través de una red europea, pretende movilizar a médicos y partes interesadas en la aplicación de biomarcadores para trazar una estrategia de tratamiento personalizado para cada paciente. En conjunto, se espera que el trabajo de PRIME-CKD reduzca la progresión de la enfermedad y la carga socioeconómica.
Objetivo
Chronic Kidney Disease (CKD) is one of the major causes of death in high income countries and its prevalence is growing rapidly. New therapies for the treatment of CKD have shown clear efficacy at a population level. Yet, individual patients respond differently with many patients showing suboptimal efficacy. This indicates that a ‘one size fits all’ approach is no longer sustainable.
Currently there are no validated pharmacodynamic biomarkers in CKD that aid in guiding optimal therapy for individual patients. Furthermore, there remains a large gap between biomarker research and actual implementation of biomarker based care in daily clinical practice.
Thus, there is an urgent need to validate and translate biomarkers as tools for daily clinical practice. PRIME-CKD has a unique advantage to address this challenge as it builds on recently discovered pharmacodynamic biomarkers for CKD treatment, and has access to a vast amount of clinical data, bio-samples. PRIME CKD will:
1) Provide a breakthrough in the pharmacotherapy of CKD with the validation and implementation of pharmacodynamic biomarkers which will advance personalized medicine.
2) Scientifically validate innovative clinical trial elements, pipelines and qualification procedures that can be used by researchers, diagnostics industries and regulatory authorities.
3) Establish a Stakeholder Network to truly engage patients, clinicians and other stakeholders in implementation of personalized medicines
4) Develop a roadmap for biomarker use in daily clinical practice for the optimal treatment of CKD.
These results will enable clinicians to match patients with CKD with the most effective available drug within the shortest possible timeframe leading to less disease burden and progression of disease, enhanced quality of life and increased cost-efficiency. PRIME-CKD results will thus unlock the potential of biomarkers in healthcare and close the gap between biomarker research and clinical use in daily practice.
Ámbito científico
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HORIZON-RIA - HORIZON Research and Innovation ActionsCoordinador
9713 GZ Groningen
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