Descrizione del progetto
Prevenire le malattie cardiovascolari mediante un’impronta immunologica
Alcune prove epidemiologiche suggeriscono la presenza di una correlazione tra l’infiammazione cronica e il rischio di malattia cardiovascolare. Comprendere il legame meccanicistico tra questi due aspetti può contribuire allo sviluppo di strategie di prevenzione che riducono l’infiammazione pur mantenendo sano il sistema immunitario. Per raggiungere questo obiettivo, il progetto CARE-IN-HEALTH, finanziato dall’UE, propone di integrare dati omici e clinici provenienti da una grande rete di collaboratori in un sistema di supporto decisionale basato sull’IA. L’obiettivo è fornire firme individuali per i pazienti che fungeranno da base per porre rimedio all’infiammazione. Poiché milioni di persone soffrono e muoiono a causa di malattie cardiovascolari, il sistema di CARE-IN-HEALTH dovrebbe prevenirne la transizione e favorire una vita sana.
Obiettivo
With 1.9 million deaths and an economic burden estimated to €200 billion each year in Europe, cardiovascular diseases (CVD) represent a significant public health problem with clear unmet needs in terms of prevention. Chronic inflammation is a critical residual risk for the health to CVD transition with limited possibilities to stop it without causing immunosuppression. To tackle this issue, CARE-IN-HEALTH propose to identify the resolution of inflammation to develop new prevention strategies to lower inflammation with a retained immune defence against infections to sustainably stay healthy. As chronic inflammation and CVD are driven and regulated by lipids, an interdisciplinary consortium of highly experienced centres has been assembled to collect, integrate, and exploit epidemiological, multi-omics and immune data to be translated into the CARE-IN-HEALTH ATLAS, which will be provided openly accessible for the scientific community and health care professionals. Such knowledge base will not only allow to systematically identify and validate an individual’s critical immune pathways through AI-empowered models and clinical translation but most importantly will provide tools for drawing a personalized blueprint on how to build a unique model for each citizen’s resolution of inflammation. To apply these findings, a digital CARE-IN-HEALTH MCDSS (multi-criteria decision support system), will be developed to guide health care professional to design personalized CVD prevention strategies. To further extend project’s findings and empower citizens, a CARE-IN-HEALTH BIOSENSOR point-of-care will be constructed to monitor resolution of inflammation. By evaluating these tools in real life settings through two proof-of-concept clinical trials, CARE-IN-HEALTH aims to propose a true paradigm shift for the public health needs on how to stay staying healthy in a rapidly changing society by promoting resolution of inflammation.
Campo scientifico
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsbiosensors
- medical and health scienceshealth sciencespublic health
- natural sciencesbiological sciencesbiochemistrybiomoleculeslipids
- medical and health sciencesclinical medicinecardiologycardiovascular diseases
Parole chiave
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Meccanismo di finanziamento
HORIZON-RIA - HORIZON Research and Innovation ActionsCoordinatore
75654 Paris
Francia