Description du projet
Transition entre la santé et les maladies inflammatoires de l’intestin
Les maladies inflammatoires de l’intestin (MII) se caractérisent par une inflammation chronique de la muqueuse du côlon et de l’intestin grêle. Il n’existe actuellement aucun biomarqueur qui permette de prédire le risque de développer une MII. Le projet miGut-Health, financé par l’UE, propose de répondre à ce besoin non satisfait en intégrant des modèles de maladies et des données moléculaires et cliniques à de nouvelles technologies. En outre, les chercheurs étudieront l’impact de l’alimentation et du microbiome intestinal sur l’inflammation intestinale. Collectivement, le projet aidera à comprendre comment des individus en bonne santé peuvent développer une MII et incitera les patients à s’auto prendre en charge grâce à des solutions de santé en ligne.
Objectif
The miGut-Health consortium aims to develop a personalized blueprint of intestinal health to predict and prevent inflammatory bowel disease. The overall goal is to deliver interdisciplinary solutions (molecular, nutritional, eHealth and patient engagement/empowerment level) for health promotion and disease prevention that would enable active patient engagement in health and self-care management.
Taking on this mission, miGut-Health pursues the following strategic goals:
- To integrate state-of-the-art omics (molecular, clinical, nutrition, social and environmental) for identification of actionable biomarkers, risk and health promoting factors linked to health-to-disease transition in the general population, IBD high risk persons, as well as IBD patients.
- To perform systems-level analyses of chronic inflammation by applying integrative models from omics and clinical data to predict risk for health-to-disease transition in IBD.
- To perform a proof-of-concept controlled clinical trial studying a nutrient elimination diet (here: gluten-free diet) and its impact on intestinal inflammation in IBD patients and high-risk individuals.
- To exploit the impact of microbiome-derived diet-associated metabolites on gut inflammation reversion and restoration of barrier integrity and function using an innovative co-culture system of primary human intestinal organoids and sorted immune cell subsets.
- To develop and apply novel technologies (sensors, mobile apps) to dynamically monitor individual nutrition as well as physical activity and principal health status.
- To implement a patient-centered approach for personalized health and self-care engagement targeted at IBD patients, individuals at risk for IBD and the general population as well as tools for health-care professionals.
Champ scientifique
- medical and health scienceshealth scienceshealth care serviceseHealth
- medical and health sciencesclinical medicinegastroenterologyinflammatory bowel disease
- medical and health sciencesbasic medicineimmunology
- medical and health scienceshealth sciencesnutrition
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensors
Mots‑clés
Programme(s)
Régime de financement
HORIZON-RIA - HORIZON Research and Innovation ActionsCoordinateur
23562 Lübeck
Allemagne