Projektbeschreibung
Den Übergang vom gesunden Darm zur entzündlichen Erkrankung erforschen
Entzündliche Darmerkrankungen sind durch chronische Entzündungen der Auskleidung des Dickdarms und des Dünndarms gekennzeichnet. Gegenwärtig gibt es keine Biomarker zur Vorhersage des Risikos einer Person, entzündliche Darmerkrankungen zu entwickeln. Das EU-finanzierte Projekt miGut-Health schlägt vor, diesen ungedeckten Bedarf durch die Einbindung von Krankheitsmodellen, molekularen und klinischen Daten sowie neuartigen Technologien zu decken. Zudem werden die Forschenden den Einfluss der Ernährung und des Darmmikrobioms auf Darmentzündungen untersuchen. Insgesamt wird das Projekt dazu beitragen, zu verstehen, wie bei gesunden Menschen der Übergang zu entzündlichen Darmerkrankungen vor sich geht, und daran arbeiten, die Betroffenen durch eHealth-Lösungen in das Selbstmanagement einzubeziehen.
Ziel
The miGut-Health consortium aims to develop a personalized blueprint of intestinal health to predict and prevent inflammatory bowel disease. The overall goal is to deliver interdisciplinary solutions (molecular, nutritional, eHealth and patient engagement/empowerment level) for health promotion and disease prevention that would enable active patient engagement in health and self-care management.
Taking on this mission, miGut-Health pursues the following strategic goals:
- To integrate state-of-the-art omics (molecular, clinical, nutrition, social and environmental) for identification of actionable biomarkers, risk and health promoting factors linked to health-to-disease transition in the general population, IBD high risk persons, as well as IBD patients.
- To perform systems-level analyses of chronic inflammation by applying integrative models from omics and clinical data to predict risk for health-to-disease transition in IBD.
- To perform a proof-of-concept controlled clinical trial studying a nutrient elimination diet (here: gluten-free diet) and its impact on intestinal inflammation in IBD patients and high-risk individuals.
- To exploit the impact of microbiome-derived diet-associated metabolites on gut inflammation reversion and restoration of barrier integrity and function using an innovative co-culture system of primary human intestinal organoids and sorted immune cell subsets.
- To develop and apply novel technologies (sensors, mobile apps) to dynamically monitor individual nutrition as well as physical activity and principal health status.
- To implement a patient-centered approach for personalized health and self-care engagement targeted at IBD patients, individuals at risk for IBD and the general population as well as tools for health-care professionals.
Wissenschaftliches Gebiet
- medical and health scienceshealth scienceshealth care serviceseHealth
- medical and health sciencesclinical medicinegastroenterologyinflammatory bowel disease
- medical and health sciencesbasic medicineimmunology
- medical and health scienceshealth sciencesnutrition
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensors
Schlüsselbegriffe
Programm/Programme
Thema/Themen
Aufforderung zur Vorschlagseinreichung
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HORIZON-RIA - HORIZON Research and Innovation ActionsKoordinator
23562 Lübeck
Deutschland