Descrizione del progetto
Il passaggio dalla salute alla malattia infiammatoria intestinale
La malattia infiammatoria intestinale è caratterizzata dall’infiammazione cronica del rivestimento del colon e dell’intestino tenue. Al momento, non esistono biomarcatori per prevedere il rischio di una persona di sviluppare questo tipo di malattia. Il progetto miGut-Health, finanziato dall’UE, propone di intervenire su questa esigenza non soddisfatta integrando i modelli della malattia, dati molecolari e clinici e tecnologie innovative. Inoltre, il gruppo di ricerca studierà l’impatto dell’alimentazione e del microbioma intestinale sull’infiammazione intestinale. Nel complesso, il progetto aiuterà a comprendere in che modo persone sane possono sviluppare una malattia infiammatoria intestinale. Inoltre, coinvolgerà i pazienti nell’autogestione tramite soluzioni della sanità elettronica.
Obiettivo
The miGut-Health consortium aims to develop a personalized blueprint of intestinal health to predict and prevent inflammatory bowel disease. The overall goal is to deliver interdisciplinary solutions (molecular, nutritional, eHealth and patient engagement/empowerment level) for health promotion and disease prevention that would enable active patient engagement in health and self-care management.
Taking on this mission, miGut-Health pursues the following strategic goals:
- To integrate state-of-the-art omics (molecular, clinical, nutrition, social and environmental) for identification of actionable biomarkers, risk and health promoting factors linked to health-to-disease transition in the general population, IBD high risk persons, as well as IBD patients.
- To perform systems-level analyses of chronic inflammation by applying integrative models from omics and clinical data to predict risk for health-to-disease transition in IBD.
- To perform a proof-of-concept controlled clinical trial studying a nutrient elimination diet (here: gluten-free diet) and its impact on intestinal inflammation in IBD patients and high-risk individuals.
- To exploit the impact of microbiome-derived diet-associated metabolites on gut inflammation reversion and restoration of barrier integrity and function using an innovative co-culture system of primary human intestinal organoids and sorted immune cell subsets.
- To develop and apply novel technologies (sensors, mobile apps) to dynamically monitor individual nutrition as well as physical activity and principal health status.
- To implement a patient-centered approach for personalized health and self-care engagement targeted at IBD patients, individuals at risk for IBD and the general population as well as tools for health-care professionals.
Campo scientifico
- medical and health scienceshealth scienceshealth care serviceseHealth
- medical and health sciencesclinical medicinegastroenterologyinflammatory bowel disease
- medical and health sciencesbasic medicineimmunology
- medical and health scienceshealth sciencesnutrition
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensors
Parole chiave
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Meccanismo di finanziamento
HORIZON-RIA - HORIZON Research and Innovation ActionsCoordinatore
23562 Lübeck
Germania