Descripción del proyecto
La transición de la salud a la enfermedad inflamatoria intestinal
La enfermedad inflamatoria intestinal (EII) se caracteriza por una inflamación crónica de la mucosa del colon y el intestino delgado. Hoy en día, no existen biomarcadores para predecir el riesgo de una persona de desarrollar EII. El objetivo del proyecto miGut-Health, financiado con fondos europeos, es abordar esta necesidad no satisfecha al combinar modelos de enfermedades y datos moleculares y clínicos con nuevas tecnologías. Además, sus investigadores examinarán el efecto de la alimentación y el microbioma intestinal en la inflamación intestinal. En conjunto, el equipo del proyecto ayudará a comprender cómo las personas sanas pueden empezar a padecer EII y a involucrar a los enfermos en su autotratamiento a través de tecnologías de sanidad electrónica.
Objetivo
The miGut-Health consortium aims to develop a personalized blueprint of intestinal health to predict and prevent inflammatory bowel disease. The overall goal is to deliver interdisciplinary solutions (molecular, nutritional, eHealth and patient engagement/empowerment level) for health promotion and disease prevention that would enable active patient engagement in health and self-care management.
Taking on this mission, miGut-Health pursues the following strategic goals:
- To integrate state-of-the-art omics (molecular, clinical, nutrition, social and environmental) for identification of actionable biomarkers, risk and health promoting factors linked to health-to-disease transition in the general population, IBD high risk persons, as well as IBD patients.
- To perform systems-level analyses of chronic inflammation by applying integrative models from omics and clinical data to predict risk for health-to-disease transition in IBD.
- To perform a proof-of-concept controlled clinical trial studying a nutrient elimination diet (here: gluten-free diet) and its impact on intestinal inflammation in IBD patients and high-risk individuals.
- To exploit the impact of microbiome-derived diet-associated metabolites on gut inflammation reversion and restoration of barrier integrity and function using an innovative co-culture system of primary human intestinal organoids and sorted immune cell subsets.
- To develop and apply novel technologies (sensors, mobile apps) to dynamically monitor individual nutrition as well as physical activity and principal health status.
- To implement a patient-centered approach for personalized health and self-care engagement targeted at IBD patients, individuals at risk for IBD and the general population as well as tools for health-care professionals.
Ámbito científico
- medical and health scienceshealth scienceshealth care serviceseHealth
- medical and health sciencesclinical medicinegastroenterologyinflammatory bowel disease
- medical and health sciencesbasic medicineimmunology
- medical and health scienceshealth sciencesnutrition
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensors
Palabras clave
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaRégimen de financiación
HORIZON-RIA - HORIZON Research and Innovation ActionsCoordinador
23562 Lübeck
Alemania