Opis projektu
Rozwój nieswoistego zapalenia jelit u zdrowych osób
Nieswoiste zapalenie jelit charakteryzuje się przewlekłym stanem zapalnym tkanki wyściełającej jelito grube i cienkie. Obecnie brak jest biomarkerów pozwalających przewidzieć ryzyko wystąpienia tej choroby u poszczególnych pacjentów. Celem finansowanego ze środków UE projektu miGut-Health jest odpowiedź na tę niezaspokojoną potrzebę poprzez połączenie modeli chorób oraz danych molekularnych i klinicznych z nowatorskimi technologiami. Ponadto naukowcy zbadają wpływ diety i mikrobiomu jelitowego na stan zapalny jelit. Ogółem projekt pomoże zrozumieć, w jaki sposób u zdrowych osób rozwija się choroba i zaangażować pacjentów w samokontrolę poprzez rozwiązania z dziedziny e-zdrowia.
Cel
The miGut-Health consortium aims to develop a personalized blueprint of intestinal health to predict and prevent inflammatory bowel disease. The overall goal is to deliver interdisciplinary solutions (molecular, nutritional, eHealth and patient engagement/empowerment level) for health promotion and disease prevention that would enable active patient engagement in health and self-care management.
Taking on this mission, miGut-Health pursues the following strategic goals:
- To integrate state-of-the-art omics (molecular, clinical, nutrition, social and environmental) for identification of actionable biomarkers, risk and health promoting factors linked to health-to-disease transition in the general population, IBD high risk persons, as well as IBD patients.
- To perform systems-level analyses of chronic inflammation by applying integrative models from omics and clinical data to predict risk for health-to-disease transition in IBD.
- To perform a proof-of-concept controlled clinical trial studying a nutrient elimination diet (here: gluten-free diet) and its impact on intestinal inflammation in IBD patients and high-risk individuals.
- To exploit the impact of microbiome-derived diet-associated metabolites on gut inflammation reversion and restoration of barrier integrity and function using an innovative co-culture system of primary human intestinal organoids and sorted immune cell subsets.
- To develop and apply novel technologies (sensors, mobile apps) to dynamically monitor individual nutrition as well as physical activity and principal health status.
- To implement a patient-centered approach for personalized health and self-care engagement targeted at IBD patients, individuals at risk for IBD and the general population as well as tools for health-care professionals.
Dziedzina nauki
- medical and health scienceshealth scienceshealth care serviceseHealth
- medical and health sciencesclinical medicinegastroenterologyinflammatory bowel disease
- medical and health sciencesbasic medicineimmunology
- medical and health scienceshealth sciencesnutrition
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensors
Słowa kluczowe
Program(-y)
Zaproszenie do składania wniosków
Zobacz inne projekty w ramach tego zaproszeniaSystem finansowania
HORIZON-RIA - HORIZON Research and Innovation ActionsKoordynator
23562 Lübeck
Niemcy