Discovering chronic inflammation biomarkers that define key stages in the Healthy-to-NASH (non-alcoholic steatohepatitis) transition to inform early prevention and treatment strategies

Informazioni relative al progetto

halt-RONIN

ID dell’accordo di sovvenzione: 101095679

DOI

10.3030/101095679

Data della firma CE 22 Novembre 2022

Data di avvio 1 Dicembre 2022

Data di completamento 30 Novembre 2026

Finanziato da

• Health

Costo totale

€ 6 721 927,53

Contributo UE

€ 6 721 927,28

Coordinato da

UNIVERSIDAD COMPLUTENSE DE MADRID
Spain

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (2)

Data Management Plan (DMP)

A data management plan following the guidelines of the FAIR and GDPR principles using the Horizon Europe template and rules

Dissemination, communication and exploitation strategy

Development of a common Dissemination and Exploitation plan in the Project, which will be used by all the partners involved in Halt-RONIN Project.

Websites, patent fillings, videos etc. (1)

Project Website Launch

Since the beginning of the project a data management and protection plan will be established.

Pubblicazioni

Peer reviewed articles (63)

Pleiotropy of Progesterone Receptor Membrane Component 1 in Modulation of Cytochrome P450 Activity

Autori: Barata, I.S.; Rueff, J.; Kranendonk, M.; Esteves, F
Pubblicato in: J Xenobiotic, ISSN 2039-4713
Editore: MDPI
DOI: 10.3390/JOX14020034

LSECtin attenuates hepatic Th17 expansion in a murine model of cirrhosis and signals through the LAG-3 receptor

Autori: Sebastián Martínez-López, Oriol Juanola, Isabel Gómez-Hurtado, Enrique Ángel-Gomis, Paula Boix, Anabel Fernández-Iglesias, Alex Gallardo-Cruz, Francisco Javier Cubero, Jordi Gracia-Sancho, Amaya Puig-Kröger, Esther Caparrós, Rubén Francés
Pubblicato in: JHEP Reports, Numero 7, 2025, ISSN 2589-5559
Editore: Elsevier BV
DOI: 10.1016/J.JHEPR.2025.101482

Endoscopic ultrasound portal pressure gradient: possible discrepancies in metabolic dysfunction-associated steatotic liver disease-related portal pressure measurements

Autori: Jesús Rivera-Esteban, Daniel de la Iglesia Garcia, Belen Agudo-Castillo, Jose Luis Calleja, Elba Llop
Pubblicato in: Endoscopy, Numero 57, 2025, ISSN 0013-726X
Editore: Georg Thieme Verlag KG
DOI: 10.1055/A-2423-4738

Rechallenge in idiosyncratic drug-induced liver injury: An analysis of cases in two large prospective registries according to existing definitions

Autori: J.M. Pinazo-Bandera, H. Niu, I. Alvarez-Alvarez, I. Medina-Cáliz, E. Del Campo-Herrera, A. Ortega-Alonso, M. Robles-Díaz, N. Hernández, R. Paraná, V. Nunes, M. Girala, F. Bessone, M.I. Lucena, R.J. Andrade, M. García Cortés
Pubblicato in: Pharmacological Research, Numero 203, 2024, ISSN 1043-6618
Editore: Elsevier BV
DOI: 10.1016/J.PHRS.2024.107183

Improving human mesenchymal stem cell-derived hepatic cell energy metabolism by manipulating glucose homeostasis and glucocorticoid signalling.

Autori: Rodrigues JS, Pereira AF, Camões SP, Serras AS, Morais VA, Ruas JL, Miranda JP.
Pubblicato in: Front. Endocrinol, 2022, ISSN 1664-2392
Editore: Frontiers Media S.A.
DOI: 10.3389/FENDO.2022.1043543

FTO/m6A/GPNMB axis: a novel promising target for hepatocellular carcinoma (HCC) treatment?

Autori: Bernd Heinrich, Francisco Javier Cubero
Pubblicato in: Gut, Numero 74, 2024, ISSN 0017-5749
Editore: BMJ
DOI: 10.1136/gutjnl-2024-332934

JNKs protect from cholestatic liver disease progression by modulating Apelin signalling

Autori: Mohamed MR, Haybaeck J, Wu H, Su H, Bartneck M, Lin C, Boekschoten MV, Boor P, Goeppert B, Rupp C, Strnad P, Davis RJ, Cubero FJ, Trautwein C
Pubblicato in: JHEP Rep., ISSN 2589-5559
Editore: Elsevier BV
DOI: 10.1016/J.JHEPR.2023.100854

Stard1 promotes cholestatic liver injury and disease progression by sensitizing to bile acid hepatotoxicity

Autori: Laura Conde de la Rosa, Laura Fàbrega, Sandra Torres, Susana Nuñez, Vicent Ribas, Paula Segalés, Ricardo Espinosa-Escudero, Estel Solsona, María Jesús Monte, Alvaro Diaz-Gonzalez, José J. G. Marin, Carmen García-Ruiz, Jose C. Fernandez-Checa
Pubblicato in: Hepatology, 2025, ISSN 0270-9139
Editore: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/HEP.0000000000001184

Drug-induced Liver Injury in Latin America: 10-year Experience of the Latin American DILI (LATINDILI) Network

Autori: Fernando Bessone, Nelia Hernandez, Inmaculada Medina-Caliz, Miren García-Cortés, María I. Schinoni, Manuel Mendizabal, Daniela Chiodi, Vinicius Nunes, Ezequiel Ridruejo, Ximena Pazos, Genario Santos, Eduardo Fassio, Raymundo Parana, Virginia Reggiardo, Hugo Tanno, Adriana Sanchez, Federico Tanno, Pedro Montes, Martin Tagle, Marco Arrese, Javier Brahm, Marcos Girala, M. Isabel Lizarzabal, Enrique Carrera, Alina Zerega, Carla Bianchi, Laura Reyes, Daina Arnedillo, Antonella Cordone, Gisela Gualano, Fernanda Jaureguizahar, Gabriel Rifrani, Mercedes Robles-Díaz, Aida Ortega-Alonso, José M. Pinazo-Bandera, Camilla Stephens, Judith Sanabria-Cabrera, Elvira Bonilla-Toyos, Hao Niu, Ismael Alvarez-Alvarez, M. Isabel Lucena, Raul J. Andrade
Pubblicato in: Clinical Gastroenterology and Hepatology, Numero 23, 2024, ISSN 1542-3565
Editore: Elsevier BV
DOI: 10.1016/j.cgh.2024.06.030

Mitochondrial cholesterol: Metabolism and impact on redox biology and disease

Autori: Leire Goicoechea,a,b,c Laura Conde de la Rosa,a,b,c Sandra Torres,a,b,c Carmen García-Ruiz,a,b,c,d,∗∗ and José C. Fernández-Checaa,b,c,d,∗
Pubblicato in: Redox Biology, 2023, ISSN 2213-2317
Editore: Elsevier
DOI: 10.1016/J.REDOX.2023.102643

Enhancing the Maturity and Diclofenac Metabolism Ability of Mesenchymal Stem Cell‐Derived Human Hepatocytes In Vitro Using Microfluidics Technology

Autori: Joana Saraiva Rodrigues, Sofia Relvas, Pedro Monteiro Condelipes, Bárbara Silva, Raquel Bozzo, Paula Guedes de Pinho, Virginia Chu, Fernando Remião, João Pedro Conde, Joana Paiva Miranda
Pubblicato in: Biotechnology Journal, Numero 20, 2025, ISSN 1860-6768
Editore: Wiley
DOI: 10.1002/BIOT.70037

Patient-derived liver organoids recapitulate liver epithelial heterogeneity and enable precision modeling of alcohol-related liver disease

Autori: Silvia Ariño, Raquel Ferrer-Lorente, Guillermo Serrano, Laura Zanatto, Raquel A. Martínez-García de la Torre, Jordi Gratacós-Ginès, Ana Belén Rubio, Martina Pérez, Carlos Mateos-Sánchez, Beatriz Aguilar-Bravo, Stephen Atkinson, Zhengqing Xu, Paula Cantallops-Vilà, Laura Sererols-Viñas, Paloma Ruiz-Blázquez, Aina Rill, Yiliam Fundora, Juan José Lozano, Mar Coll, Idoia Ochoa, Silvia Affo, Anna Moles, Elisabetta Mereu, Ramón Bataller, Elisa Pose, Pau Sancho-Bru
Pubblicato in: Journal of Hepatology, Numero 84, 2026, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/J.JHEP.2025.07.014

A Novel Mouse Model of Combined Hepatocellular-Cholangiocarcinoma Induced by Diethylnitrosamine and Loss of Ppp2r5d.

Autori: Domènech Omella J, Cortesi EE, Verbinnen I, Remmerie M, Wu H, Cubero FJ, Roskams T, Janssens V
Pubblicato in: Cancers (Basel), 2023, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/CANCERS15164193

Metabolic dysfunction–associated steatotic liver disease alters brain function and behavior: Insights from liver-targeted siRNA therapy

Autori: Teresa Cardoso Delgado; Celia Martín-Cuevas; Ana C. Sánchez Hidalgo; Antonio Gil Gómez; Claudia M. Rejano Gordillo; Jon Landa; Rocío Gallego Durán; Naroa Goikoetxea-Usandizaga; Irene González-Recio; Clàudia Gil-Pitarch; L. Estefanía Zapata-Pavas; Jon Ander Barrenechea-Barrenechea; Carolina Conter; Luis Alfonso Martínez-Cruz; Víctor D. Ramos Herrero; Rubén Nogueiras; Mikel Azkargorta; Felix Elortza; Verónica Moncho-Amor; Javier Crespo; Ander Matheu; Manuel Romero Gómez; Benedicto Crespo-Facorro; María Luz Martínez-Chantar
Pubblicato in: Science Advances, 2025, ISSN 2375-2548
Editore: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.ADY9758

Three-Dimensional Hepatocyte Spheroids: Model for Assessing Chemotherapy in Hepatocellular Carcinoma

Autori: Felix Royo; Clara Garcia-Vallicrosa, Maria Azparren-Angulo, Guillermo Bordanaba-Florit, Silvia Lopez-Sarrio, Juan Manuel Falcon-Perez
Pubblicato in: Biomedicines, ISSN 2227-9059
Editore: MDPI
DOI: 10.3390/BIOMEDICINES12061200

Cathepsin D is essential for the degradomic shift of macrophages required to resolve liver fibrosis

Autori: Paloma Ruiz-Blázquez, María Fernández-Fernández, Valeria Pistorio, Celia Martinez-Sanchez, Michele Costanzo, Paula Iruzubieta, Ekaterina Zhuravleva, Júlia Cacho-Pujol, Silvia Ariño, Alejandro Del Castillo-Cruz, Susana Núñez, Jesper B. Andersen, Margherita Ruoppolo, Javier Crespo, Carmen García-Ruiz, Luigi Michele Pavone, Thomas Reinheckel, Pau Sancho-Bru, Mar Coll, José C. Fernández-Checa, Anna Moles
Pubblicato in: Molecular Metabolism, Numero 87, 2024, ISSN 2212-8778
Editore: Elsevier BV
DOI: 10.1016/j.molmet.2024.101989

Cirrhosis‐downregulated <scp>LSECtin</scp> can be retrieved by cytokines, shifts the <scp>TLR</scp>‐induced <scp>LSECs</scp> secretome and correlates with the hepatic Th response

Autori: Sebastián Martínez‐López; Enrique Ángel‐Gomis; Isabel Gómez‐Hurtado; Anabel Fernández‐Iglesias; Javier Morante; Jordi Gracia‐Sancho; Paula Boix; Francisco J. Cubero; Pedro Zapater; Esther Caparrós; Rubén Francés
Pubblicato in: Liver International, 2024, ISSN 1478-3231
Editore: Wiley
DOI: 10.1111/LIV.15836

Obesity under the moonlight of c-MYC

Autori: Yulia A. Nevzorova and Francisco Javier Cubero
Pubblicato in: Frontiers in cells and developmental biology, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/FCELL.2023.1293218

Biochimica et Biophysica Acta - Molecular Basis of Disease

Autori: Guillermo, Bordanaba-Florit; Félix, Royo; Oihane E, Albóniga; Aled, Clayton; Juan Manuel, Falcón-Pérez; Jason, Webber
Pubblicato in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2024, ISSN 0925-4439
Editore: Elsevier
DOI: 10.1016/J.BBADIS.2024.167229

Reproducibility of extracellular vesicle research

Autori: Rossella Crescitelli; Juan Falcon‐Perez; An Hendrix; Metka Lenassi; Le Thi Nguyet Minh; Takahiro Ochiya; Nicole Noren Hooten; Ursula Sandau; Clotilde Théry; Rienk Nieuwland
Pubblicato in: Journal of Extracellular Vesicles, 2025, ISSN 2001-3078
Editore: Wiley
DOI: 10.1002/JEV2.70036

Curcumin encapsulated in milk small extracellular vesicles as a nanotherapeutic alternative in experimental chronic liver disease

Autori: Virginia Albaladejo-García, Laura Morán, Ana Santos-Coquillat, María I. González, Hui Ye, Elena Vázquez Ogando, Javier Vaquero, Francisco Javier Cubero, Manuel Desco, Beatriz Salinas
Pubblicato in: Biomedicine & Pharmacotherapy, 2024, ISSN 1950-6007
Editore: Elsevier
DOI: 10.1016/J.BIOPHA.2024.116381

HILPDA, a new player in NASH-driven HCC, links hypoxia signaling with ceramide synthesis

Autori: Jose C Fernandez-Checa 1, Sandra Torres 2, Carmen Garcia-Ruiz 3
Pubblicato in: Journal of Hepatology, ISSN 0168-8278
Editore: Elsevier
DOI: 10.1016/J.JHEP.2023.05.009

Novel Emerging Mechanisms in Acetaminophen (<scp>APAP</scp>) Hepatotoxicity

Autori: Alejandro Hionides‐Gutierrez, Naroa Goikoetxea‐Usandizaga, Carlos Sanz‐García, María L. Martínez‐Chantar, Francisco Javier Cubero
Pubblicato in: Liver International, 2024, ISSN 1478-3223
Editore: Wiley
DOI: 10.1111/liv.16167

GDF15 is associated with hepatocellular senescence and correlates with mortality in patients with alcohol-associated hepatitis

Autori: Teresa Rubio-Tomás; David Martí-Aguado; Delia Blaya; Silvia Ariño; Beatriz Aguilar-Bravo; Raquel A. Martínez García de la Torre; Marc Miravet-Marti; Raquel Ferrer-Lorente; Laura Zanatto; Zengqing Xu; Laura Garcia-Tercero; Carlos Mateos-Sánchez; Juan José Lozano; Isabella Dotti; Johanne Poisson; Marion Tanguy; Azucena Salas; Pierre-Emmanuel Rautou; Ramon Bataller; Pau Sancho-Bru
Pubblicato in: JHEP Reports, 2025, ISSN 2589-5559
Editore: Elsevier
DOI: 10.1016/J.JHEPR.2025.101478

Cholesterol’s new tricks propel MASH-HCC: impact in immunotherapy

Autori: Carmen Garcia-Ruiz; Sandra Torres; Jose C Fernandez-Checa
Pubblicato in: Gut, 2024, ISSN 1468-3288
Editore: BMJ
DOI: 10.1136/GUTJNL-2024-332766

Identification of PRMT5 as a therapeutic target in cholangiocarcinoma

Autori: Jasmin Elurbide, Leticia Colyn, Maria U Latasa, Iker Uriarte, Stefano Mariani, Amaya Lopez-Pascual, Emiliana Valbuena, Borja Castello-Uribe, Robert Arnes-Benito, Elena Adan-Villaescusa, Luz A Martinez-Perez, Mikel Azkargorta, Felix Elortza, Hanghang Wu, Marcin Krawczyk, Kai Markus Schneider, Bruno Sangro, Luca Aldrighetti, Francesca Ratti, Andrea Casadei Gardini, Jose J G Marin, Irene Amat, Jesus M Urman, Maria Arechederra, Maria Luz Martinez-Chantar, Christian Trautwein, Meritxell Huch, Francisco Javier Cubero, Carmen Berasain, Maite G Fernandez-Barrena, Matias A Avila
Pubblicato in: Gut, Numero 74, 2024, ISSN 0017-5749
Editore: BMJ
DOI: 10.1136/gutjnl-2024-332998

Dietary and genetic disruption of hepatic methionine metabolism induce acid sphingomyelinase to promote steatohepatitis

Autori: Cristina Alarcón-Vila 1, Naroa Insausti-Urkia 1, Sandra Torres 1, Paula Segalés-Rovira 1, Laura Conde de la Rosa 1, Susana Nuñez 1, Raquel Fucho 1, Jose C Fernández-Checa 2, Carmen García-Ruiz 3
Pubblicato in: Redox Biology, 2022, ISSN 2213-2317
Editore: Elsevier BV
DOI: 10.1016/J.REDOX.2022.102596

Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease

Autori: Alejandro H Gutierrez 1, Marina S Mazariegos 1, Susana Alemany 2, Yulia A Nevzorova 3, Francisco Javier Cubero 3, Carlos Sanz-García 4
Pubblicato in: Molecular Basis of disease, 2023, ISSN 0925-4439
Editore: Elsevier
DOI: 10.1016/J.BBADIS.2023.166660

Bile acids in liver and gastrointestinal cancer

Autori: Maria J. Monte, Laura Fàbrega, Marta R. Romero, Alvaro G. Temprano, Neil Kaplowitz, Carmen Garcia-Ruiz, Jose J.G. Marin, Jose C. Fernandez-Checa
Pubblicato in: Seminars in Cancer Biology, Numero 116, 2025, ISSN 1044-579X
Editore: Elsevier BV
DOI: 10.1016/J.SEMCANCER.2025.09.002

Expression of SREBF2 and HMGCR discriminates the viability of steatotic grafts for human liver transplantation

Autori: Anna Baulies, Sandra Torres, Raquel Fucho, Susana Núñez, Ferran Torres, Joana Ferrer-Fàbrega, Alba Díaz, Naira Rico, Juan Carlos García-Valdecasas, Josep Fuster, Ramon Adalia, David Paredes, Anto
Pubblicato in: Journal of Lipid Research, Numero 66, 2025, ISSN 0022-2275
Editore: Elsevier BV
DOI: 10.1016/J.JLR.2025.100901

Loss of Cdkn1a protects against MASLD alone or with alcohol intake by preserving lipid homeostasis

Autori: Arantza Lamas-Paz, Alejandro Hionides-Gutiérrez, Feifei Guo, Gonzalo Jorquera, Laura Morán-Blanco, Raquel Benedé-Ubieto, Mariana Mesquita, Olga Estévez-Vázquez, Kang Zheng, Marina Mazariegos, Elena Vázquez-Ogando, Elena Blázquez-López, Iris Asensio, Beste Mutlu, Beatriz Gomez-Santos, María Isabel Peligros, Javier Vaquero, Rafael Bañares, Teresa C. Delgado, María Luz Martínez-Chantar, Eduardo Martínez-Naves, Carlos Sanz-García, Mohamed Ramadan Mohamed, Sofía Tesolato, Pilar Iniesta, Rocío Gallego-Durán, Douglas Maya-Miles, Javier Ampuero, Manuel Romero-Gómez, Ana Martínez-Alcocer, David Sanfeliu-Redondo, Anabel Fernández-Iglesias, Jordi Gracia-Sancho, Mar Coll, Isabel Graupera, Pere Ginès, Andrea Ciudin, Jesús Rivera-Esteban, Juan M. Pericàs, Matías A. Ávila, Maria Dolores Frutos, Carlos Manuel Martínez-Cáceres, Bruno Ramos-Molina, Patricia Aspichueta, Pere Puigserver, Yulia A. Nevzorova, Francisco Javier Cubero
Pubblicato in: JHEP Reports, Numero 7, 2025, ISSN 2589-5559
Editore: Elsevier BV
DOI: 10.1016/j.jhepr.2024.101230

Zebrafish as a model for drug induced liver injury: state of the art and beyond

Autori: Gulcin Cakan-Akdogan, Abdul Moiz Aftab, Muazzez Celebi Cinar, Khalid A. Abdelhalim, Ozlen Konu
Pubblicato in: Exploration of Digestive Diseases, 2023, ISSN 2833-6321
Editore: Open Exploration Publishing
DOI: 10.37349/EDD.2023.00017

Roadmap to DILI research in Europe. A proposal from COST action ProEuroDILINet

Autori: M.I. Lucena, M. Villanueva-Paz, I. Alvarez-Alvarez, G.P. Aithal, E.S. Björnsson, G. Cakan-Akdogan, F.J. Cubero, F. Esteves , J.M. Falcon-Perez , B. Fromenty, C. Garcia-Ruiz, J.I. Grove, O. Konu, M. Kranendonk, G.A. Kullak-Ublick, J.P. Miranda, et al.
Pubblicato in: Pharmacological Research, 2023, ISSN 1043-6618
Editore: Elsevier
DOI: 10.1016/J.PHRS.2023.107046

The gut–liver axis in progressive steatotic liver disease: A focus on bile acid dysregulation

Autori: Panayiotis Louca, Juan M. Pericàs, Yu Lin, Afroditi Kouraki, Olga Estévez-Vázquez, María Martínez-Gómez, M. Serra Cusidó, Joanna P. Simpson, Francisco Javier Cubero, Natalie Z.M. Homer, Ana M. Valdes, Cristina Menni
Pubblicato in: The Journal of nutrition, health and aging, Numero 29, 2026, ISSN 1279-7707
Editore: Elsevier BV
DOI: 10.1016/J.JNHA.2025.100671

The Cantabria Cohort, a protocol for a population-based cohort in northern Spain

Autori: Marta Alonso-Peña, Trinidad Dierssen, Maria José Marin, Jessica Alonso-Molero, Inés Gómez-Acebo, Inés Santiuste, Jeffrey V. Lazarus, Pascual Sanchez-Juan, Galo Peralta, Javier Crespo, Marcos Lopez-Hoyos & Cantabria Cohort Collaborators
Pubblicato in: BMC Public Health, 2023, ISSN 1471-2458
Editore: BioMed Central
DOI: 10.1186/S12889-023-17318-8

Expression of HMGCS2 in intestinal epithelial cells is downregulated in inflammatory bowel disease associated with endoplasmic reticulum stress

Autori: Beatriz Martín-Adrados; Stefanie K. Wculek; Sergio Fernández-Bravo; Raúl Torres-Ruiz; Ana Valle-Noguera; Maria José Gomez-Sánchez; José Carlos Hernández-Walias; Frederico Moraes Ferreira; Ana María Corraliza; David Sancho; Vanesa Esteban; Sandra Rodriguez-Perales; Aránzazu Cruz-Adalia; Helder I. Nakaya; Azucena Salas; David Bernardo; Yolanda Campos-Martín; Elena Martínez-Zamorano; Diego Muñoz-López; Manuel Gómez del Moral; Francisco Javier Cubero; Richard S. Blumberg; Eduardo Martínez-Naves
Pubblicato in: Frontiers in Inmmunology, 2023, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2023.1185517

Neuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis

Autori: Zheng K, Hao F, Medrano-Garcia S, Chen C, Guo F, Morán-Blanco L, Rodríguez-Perales S, Torres-Ruiz R, Peligros MI, Vaquero J, Bañares R, Gómez Del Moral M, Regueiro JR, Martínez-Naves E, Mohamed MR, Gallego-Durán R, Maya D, Ampuero J, Romero-Gómez M, Gilbe
Pubblicato in: Cell Death and Disease, 2023, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/S41419-023-06029-Y

Zonal expression of StARD1 and oxidative stress in alcoholic-related liver disease

Autori: Raquel Fucho 1, Estel Solsona-Vilarrasa 1, Sandra Torres 1, Susana Nuñez 1, Naroa Insausti-Urkia 1, Albert Edo 1, Maria Calvo 2, Anna Bosch 2, Gemma Martin 2, Carlos Enrich 3, Carmen García-Ruiz 4, Jose C Fernandez-Checa
Pubblicato in: J Lipid Res, 2023, ISSN 0022-2275
Editore: Elsevier
DOI: 10.1016/J.JLR.2023.100413

Control compounds for preclinical drug-induced liver injury assessment: Consensus-driven systematic review by the ProEuroDILI network

Autori: Antonio Segovia-Zafra, Marina Villanueva-Paz, Ana Sofia Serras, Gonzalo Matilla-Cabello, Ana Bodoque-García, Daniel E. Di Zeo-Sánchez, Hao Niu, Ismael Álvarez-Álvarez, Laura Sanz-Villanueva, Sergej Godec, Irina Milisav, Pierre Bagnaninchi, Raúl J. Andrade, M Isabel Lucena, José C. Fernández-Checa, Francisco Javier Cubero, Joana Paiva Miranda, Leonard J. Nelson
Pubblicato in: Journal of Hepatology, Numero 81, 2024, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/J.JHEP.2024.04.026

CMGH Cellular and Molecular Gastroenterology and Hepatology

Autori: Mohamed Ramadan Mohamed 1, Gang Zhao 2, Ines Volkert 3, Antonio Molinaro 4, Carolin V Schneider 3, Pavel Strnad 3, Jan G Hengstler 5, Chi Xu 6, Roger J Davis 7, Kai Markus Schneider 3, Francisco Javier Cubero 8, Christian Trautwein 9
Pubblicato in: Cell Mol Gastroenterol Hepatol ., ISSN 2352-345X
Editore: Elsevier
DOI: 10.1016/J.JCMGH.2025.101588

Role of CNNM4 in the progression of cholangiocarcinoma: implications for ferroptosis and therapeutic potential

Autori: Maria Mercado-Gómez, Naroa Goikoetxea-Usandizaga, Alvaro Eguileor Giné, Miguel A Merlos Rodrigo, Marta Bento Afonso, Mikel Azkargorta, Leidy Estefanía Zapata-Pavas, Claudia M Rejano-Gordillo, Marta R Romero, Isabel Mendizabal, Pedro M Rodrigues, Hanghang Wu, Rubén Rodríguez-Agudo, Marina Serrano-Maciá, Paula Olaizola, Jon Ander Barrenechea-Barrenechea, Irene González Recio, Maite G Fernandez-Barrena, Diletta Overi, Eugenio Gaudio, Ute Schaeper, Saioa Garcia-Longarte, Mariana Yáñez-Bartolomé, Patricia Peña-SanFelix, Clàudia Gil-Pitarch, Ainhoa Lapitz, Hana Michalkova, Zbynek Heger, Carolina Conter, Rocio I R Macias, Arkaitz Carracedo, Jesús Bañales, Victor Moreno, Angela Lamarca, Rajat Singh, Teresa Cardoso Delgado, Luis Alfonso Martínez-Cruz, Felix Elortza, Matias A Avila, César Martín, Tian V. Tian, Teresa Macarulla, Daniela Buccella, Francisco Javier Cubero, Diego F Calvisi, Guido Carpino, Jose J G Marin, Cecília M P Rodrigues, Maria Luz Martinez-Chantar
Pubblicato in: Gut, 2025, ISSN 0017-5749
Editore: BMJ
DOI: 10.1136/GUTJNL-2024-333255

Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases

Autori: Ana I. Rojo, Brigitta Buttari, Susana Cadenas, Ana Rita Carlos, Antonio Cuadrado, Ana Sofia Falcão, Manuela G. López, Milen I. Georgiev, Anna Grochot-Przeczek, Sentiljana Gumeni, José Jimenez-Ville
Pubblicato in: Redox Biology, Numero 79, 2025, ISSN 2213-2317
Editore: Elsevier BV
DOI: 10.1016/J.REDOX.2024.103464

Intestinal permeability and immune‐inflammatory markers in patients with idiosyncratic drug‐induced liver injury, drug‐induced steatosis and metabolic dysfunction–associated steatotic liver disease (MASLD)

Autori: Daniel E. Di Zeo‐Sánchez, Irene Díaz‐Alberola, José María Pinazo‐Bandera, Miren García‐Cortés, Judith Sanabria‐Cabrera, Mercedes Robles‐Díaz, Ismael Álvarez‐Álvarez, M. Isabel Lucena, Raúl J. Andrade, Marina Villanueva‐Paz, Camilla Stephens
Pubblicato in: British Journal of Pharmacology, Numero 182, 2025, ISSN 0007-1188
Editore: Wiley
DOI: 10.1111/BPH.70123

Ductular reaction-associated neutrophils promote biliary epithelium proliferation in chronic liver disease

Autori: Silvia Ariño, Beatriz Aguilar-Bravo, Mar Coll, Woo-Yong Lee, Moritz Peiseler, Paula Cantallops-Vilà, Laura Sererols-Viñas, Raquel A. Martínez-García de la Torre, Celia Martínez-Sánchez, Jordi Pedragosa, Laura Zanatto, Jordi Gratacós-Ginès, Elisa Pose, Delia Blaya, Xènia Almodóvar, María Fernández-Fernández, Paloma Ruiz-Blázquez, Juan José Lozano, Silvia Affo, Anna M. Planas, Pere Ginès, Anna Moles, Paul Kubes, Pau Sancho-Bru
Pubblicato in: Journal of Hepatology, Numero 79, 2025, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/J.JHEP.2023.05.045

Fecal microbiota transplantation from female donors restores gut permeability and reduces liver injury and inflammation in middle-aged male mice exposed to alcohol

Autori: Arantza Lamas-Paz, Mariana Mesquita, Marcos Garcia-Lacarte, Olga Estévez-Vázquez, Raquel Benedé-Ubieto, Alejandro H. Gutierrez, Hanghang Wu, Hector Leal Lasalle, Javier Vaquero, Rafael Bañares, Eduardo Martínez-Naves, Sergio Roa, Yulia A. Nevzorova, Gonzalo Jorquera, Francisco Javier Cubero
Pubblicato in: Frontiers in Nutrition, Numero 11, 2024, ISSN 2296-861X
Editore: Frontiers Media SA
DOI: 10.3389/fnut.2024.1393014

Fecal Microbiota Transplantation from Young-Trained Donors Improves Cognitive Function in Old Mice Through Modulation of the Gut-Brain Axis

Autori: Camila Cerna, Nicole Vidal-Herrera, Francisco Silva- Olivares, et al.
Pubblicato in: Aging and disease, ISSN 2152-5250
Editore: International Society on Aging and Disease.
DOI: 10.14336/AD.2024.1089

Development and validation of a precise and accurate method to determine polyamine levels in cultured cells

Autori: Diana Cabrera; Mikel Pujana Vaquerizo; Belén Martínez La Osa; Amaia Zabala Letona; Arkaitz Carracedo; Juan Manuel Falcón; Sebastiaan van Liempd
Pubblicato in: Crossref, 2025, ISSN 2692-8205
Editore: BioRxiv
DOI: 10.1101/2025.05.29.654479

ECM1: a novel matricellular protein with promising antifibrotic potential

Autori: Isabel Fabregat, Francisco Javier Cubero
Pubblicato in: Gut, 2024, ISSN 0017-5749
Editore: BMJ
DOI: 10.1136/gutjnl-2024-333455

Palmitoylcarnitine impairs immunity in decompensated cirrhosis

Autori: Ingrid Wei Zhang; María Belén Sánchez-Rodríguez; Cristina López-Vicario; Mireia Casulleras; Marta Duran-Güell; Roger Flores-Costa; Ferran Aguilar; Michael Rothe; Paula Segalés; Carmen García-Ruiz; José C. Fernández-Checa; Jonel Trebicka; Vicente Arroyo; Joan Clària
Pubblicato in: JHEP Reports, 2024, ISSN 2589-5559
Editore: Elsevier
DOI: 10.1016/J.JHEPR.2024.101187

S-Adenosyl-l-methionine restores brain mitochondrial membrane fluidity and GSH content improving Niemann-Pick type C disease

Autori: Leire Goicoechea 1, Sandra Torres 1, Laura Fàbrega 1, Mónica Barrios 1, Susana Núñez 2, Josefina Casas 3, Gemma Fabrias 3, Carmen García-Ruiz 4, José C Fernández-Checa 5
Pubblicato in: Redox Biology, 2024, ISSN 2213-2317
Editore: Elsevier
DOI: 10.1016/J.REDOX.2024.103150

Mitochondria and Alcohol-Associated Liver Disease: Pathogenic Role and Target for Therapy

Autori: Sandra Torres, Josiah Hardesty, Monica Barrios, Carmen Garcia-Ruiz, Jose C. Fernandez-Checa, Ashwani K. Singal
Pubblicato in: Seminars in Liver Disease, Numero 45, 2025, ISSN 0272-8087
Editore: Georg Thieme Verlag KG
DOI: 10.1055/A-2421-5658

Non-invasive methods of monitoring Fe3O4 magnetic nanoparticle toxicity in human liver HepaRG cells using impedance biosensing and Coherent anti-Stokes Raman spectroscopic (CARS) microscopy

Autori: Kuhn, Joel; McDonald, Alison; Mongoin, Cyril; Anderson, Graham; Lafeuillade, Guillemette; Mitchell, Stephen; Elfick, Alistair P.D.; Bagnaninchi, Pierre O.; Yiu, Humphrey H.P.; Nelson, Leonard J.
Pubblicato in: Toxicology Letters, 2024, ISSN 1879-3169
Editore: Elsevier
DOI: 10.1016/J.TOXLET.2024.02.010

Single Mutations in Cytochrome P450 Oxidoreductase Can Alter the Specificity of Human Cytochrome P450 1A2-Mediated Caffeine Metabolism

Autori: Esteves, F.; Almeida, C.M.M.; Silva, S.; Saldanha, I.; Urban, P.; Rueff, J.; Pompon, D.; Truan, G.; Kranendonk, M.
Pubblicato in: Biomolecules, 2023, ISSN 2218-273X
Editore: MDPI
DOI: 10.3390/biom13071083

Breaking the barriers: the role of gut homeostasis in Metabolic-Associated Steatotic Liver Disease (MASLD)

Autori: Raquel Benedé, Francisco Javier Cubero, Yulia A. Nevzorova
Pubblicato in: Gut microbes, Numero 1, 2331460, 2024, ISSN 1949-0984
Editore: Taylor & Francis
DOI: 10.1080/19490976.2024.2331460

Prior drug allergies are associated with worse outcome in patients with idiosyncratic drug-induced liver injury: A machine learning approach for risk stratification

Autori: H. Niu, P. Solis-Muñoz, M. García-Cortés, J. Sanabria-Cabrera, M. Robles-Diaz, R. Romero-Flores, E. Bonilla-Toyos, A. Ortega-Alonso, J. M. Pinazo-Bandera, M. R. Cabello, F. Bessone, N. Hernandez, M. I. Lucena, R. J Andrade, I. Medina-Caliz, I. Álvarez-Álv
Pubblicato in: Pharmacological Research, Numero 199, 2024, ISSN 1043-6618
Editore: Academic Press
DOI: 10.1016/j.phrs.2023.107030

CAP-RNAseq: an integrated pipeline for functional annotation and prioritization of co-expression clusters

Autori: Merve Vural-Ozdeniz, Kubra Calisir, Rana Acar, Aysenur Yavuz, Mustafa M Ozgur, Ertugrul Dalgıc, Ozlen Konu
Pubblicato in: Briefings in Bioinformatics, 2024, ISSN 1477-4054
Editore: Oxford Journals
DOI: 10.1093/bib/bbad536

Randomization based evaluation of distinct topological and cancer expression characteristics of mutually acting gene pairs

Autori: Ertuğrul Dalgıç, Muazzez Çelebi-Çınar, Merve Vural-Özdeniz, Özlen Konu
Pubblicato in: Integrative Biology, Numero 17, 2025, ISSN 1757-9708
Editore: Oxford University Press (OUP)
DOI: 10.1093/INTBIO/ZYAF005

Polygenic risk score in cirrhosis: Does the etiology matter?

Autori: Alonso-Peña, Marta; Arias Loste, Maria Teresa; Cabezas, Joaquin; Iruzubieta, Paula; Crespo, Javier
Pubblicato in: Hepatology Communications, 2025, ISSN 2471-254x
Editore: Wolters Kluwer Health
DOI: 10.1097/HC9.0000000000000541

Unraveling MASLD: The Role of Gut Microbiota, Dietary Modulation, and AI-Driven Lifestyle Interventions

Autori: Carolina Jiménez-González, Marta Alonso-Peña, Paula Argos Vélez, Javier Crespo, Paula Iruzubieta
Pubblicato in: Nutrients, Numero 17, 2025, ISSN 2072-6643
Editore: MDPI AG
DOI: 10.3390/NU17091580

Inhibition of ALK3-mediated signalling pathway protects against acetaminophen-induced liver injury

Autori: Patricia Marañón 1, Esther Rey 2, Stephania C Isaza 2, Hanghang Wu 3, Patricia Rada 4, Carmen Choya-Foces 2, Antonio Martínez-Ruiz 5, María Ángeles Martín 6, Sonia Ramos 6, Carmelo García-Monzón 2, Francisco Javier Cubero 7, Ángela M Valverde 4, Águeda Go
Pubblicato in: Redox Biology, 2024, ISSN 2213-2317
Editore: Elsevier
DOI: 10.1016/J.REDOX.2024.103088

Epigenetic modifications in drug‐induced liver injury: A systematic review

Autori: Romina Lorena de los Santos‐Fernández, Antonio Segovia‐Zafra, Guillermo Paz‐López, Gonzalo Matilla‐Cabello, Hao Niu, Ismael Álvarez‐Álvarez, Camilla Stephens, Andrés González‐Jiménez, M. Isabel Lucena, Raúl J. Andrade, Inmaculada Medina‐Cáliz
Pubblicato in: British Journal of Clinical Pharmacology, Numero 91, 2025, ISSN 0306-5251
Editore: Wiley
DOI: 10.1111/BCP.70053

Atypical and fatal presentation of acute liver failure

Autori: Ana Pérez González, Javier Martín López, Jesus Rivera-Esteban
Pubblicato in: European Journal of Internal Medicine, Numero 140, 2025, ISSN 0953-6205
Editore: Elsevier BV
DOI: 10.1016/J.EJIM.2025.05.036

Seladelpar: New hope for patients with primary biliary cholangitis

Autori: Nevzorova, Yulia A.; Cubero, Francisco Javier
Pubblicato in: Med, 2024, ISSN 0121-5256
Editore: Cell Press
DOI: 10.1016/j.medj.2024.03.019

Conference proceedings (2)

EACR2024 Congress Abstract

Autori: No authors
Pubblicato in: Molecular oncology, ISSN 1878-0261
Editore: Elsevier
DOI: 10.1002/1878-0261.13683

Proceedings of the 5th Meeting of Translational Hepatology, organized by the Spanish Association for the Study of the Liver (AEEH)

Autori: Edilmar Alvarado-Tapias, Douglas Maya-Miles, Agustin Albillos, Rocio Aller, Javier Ampuero, Raul J. Andrade, Maria Arechederra, Patricia Aspichueta, Jesus M. Banales, Ana Blas-García, Esther Caparros, Teresa Cardoso Delgado, Antonio Carrillo-Vico, Joan Claria, Francisco Javier Cubero, Alberto Díaz-Ruiz, Maite G. Fernández-Barrena, Anabel Fernández-Iglesias, Sonia Fernández-Veledo, Ruben Francés, Rocío Gallego-Durán, Jordi Gracia-Sancho, Manuel Irimia, Sabela Lens, María Luz Martínez-Chantar, Beatriz Mínguez, Rocío Muñoz-Hernández, Rubén Nogueiras, Bruno Ramos-Molina, Mar Riveiro-Barciela, Manuel L. Rodríguez-Perálvarez, Manuel Romero-Gómez, Guadalupe Sabio, Pau Sancho-Bru, Meritxell Ventura-Cots, Silvia Vidal, Manuel D. Gahete
Pubblicato in: Gastroenterología y Hepatología (English Edition), Numero 47, 2024, ISSN 2444-3824
Editore: Elsevier BV
DOI: 10.1016/j.gastre.2024.502207