Minimally-Invasive Soft-Robot-Assisted Deep-Brain Localized Therapeutics Delivery for Neurological Disorders

Project Information

SoftReach

Grant agreement ID: 101099145

DOI

10.3030/101099145

Project closed

EC signature date 21 November 2022

Start date 1 February 2023

End date 31 July 2026

Funded under

• The European Innovation Council (EIC)

Total cost

€ 2 158 000,00

EU contribution

€ 2 158 000,00

Coordinated by

IDRYMA TECHNOLOGIAS KAI EREVNAS
Greece

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (6)

Ethics evaluation
Development of map generation & planner
System specifications & architecture
Risk analysis and mitigation plans
Website and project logo

Website and project logo information with also social media links.

Computational models for simulation and control

Demonstrators, pilots, prototypes (1)

Experiment setup for stereotactic delivery of TCPs in mice BV

Publications

Peer reviewed articles (14)

Comprehensive characterization of the neurogenic and neuroprotective action of a novel TrkB agonist using mouse and human stem cell models of Alzheimer’s disease

Author(s): Despoina Charou, Thanasis Rogdakis, Alessia Latorrata, Maria Valcarcel, Vasileios Papadogiannis, Christina Athanasiou, Alexandros Tsengenes, Maria Anna Papadopoulou, Dimitrios Lypitkas, Matthieu D. Lavigne, Theodora Katsila, Rebecca C. Wade, M. Zameel Cader, Theodora Calogeropoulou, Achille Gravanis, Ioannis Charalampopoulos
Published in: Stem Cell Research & Therapy, Issue 15, 2024, ISSN 1757-6512
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13287-024-03818-W

Medical & healthcare robotics: a roadmap for enhanced precision, safety, and efficacy

Author(s): Dimitris K Iakovidis, Panagiotis Vartholomeos, Alexia Le Gall, Matteo Cianchetti, Oliver Ozioko, Ravinder Dahiya, Evangelos Mazomenos, Francisco Vasconcelos, Danail Stoyanov, Joe Philpott, Taha Erdem, Gerard Cummins, Gastone Ciuti, Carlo A Seneci, Christos Bergeles, Minsoo Kim, Salvador Pané, Bradley J Nelson, Ioannis Poulakakis, Odysseas Simatos, Panagiotis Polygerinos, Petros Toupas, Dimitrios Giakoumis, Dimitrios Tzovaras, Zhidong Su, Weihua Sheng, Andreas S Panayides, Eftychios G Christoforou, Constantinos S Pattichis
Published in: Measurement Science and Technology, Issue 36, 2025, ISSN 0957-0233
Publisher: IOP Publishing
DOI: 10.1088/1361-6501/AE09BF

Tip-Growing Robots: Design, Theory, Application

Author(s): Shamsa Al Harthy, S.M. Hadi Sadati, Cédric Girerd, Sukjun Kim, Alessio Mondini, Zicong Wu, Brandon Saldarriaga, Carlo A. Seneci, Barbara Mazzolai, Tania K. Morimoto, Christos Bergeles
Published in: IEEE Transactions on Robotics, Issue 41, 2025, ISSN 1552-3098
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/TRO.2025.3608701

p75 neurotrophin receptor shapes the dynamics of adult hippocampal neurogenesis in Alzheimer’s disease

Author(s): Maria Anna Papadopoulou, Konstantina Chanoumidou, Maria Peteinareli, Electra Tsaglioti, Konstantina Michalaki, Matthieu D. Lavigne, Ioannis Charalampopoulos
Published in: Alzheimer's Research & Therapy, Issue 18, 2026, ISSN 1758-9193
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13195-026-01989-7

Multimodal beneficial effects of BNN27, a nerve growth factor synthetic mimetic, in the 5xFAD mouse model of Alzheimer’s disease

Author(s): Maria Kokkali, Kanelina Karali, Evangelia Thanou, Maria Anna Papadopoulou, Ioanna Zota, Alexandros Tsimpolis, Paschalis Efstathopoulos, Theodora Calogeropoulou, Ka Wan Li, Kyriaki Sidiropoulou, Achille Gravanis, Ioannis Charalampopoulos
Published in: Molecular Psychiatry, Issue 30, 2025, ISSN 1359-4184
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41380-024-02833-W

An Optical Coupling-Based Method for Catheter Shape Sensing Using Multicore Optical Fiber

Author(s): Argyris N. Stassinakis, Panagiotis Vartholomeos
Published in: IEEE Sensors Journal, 2026, ISSN 1530-437X
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/JSEN.2026.3731840

Stimulating myelin restoration with BDNF: a promising therapeutic approach for Alzheimer's disease

Author(s): Ioanna Zota, Konstantina Chanoumidou, Achille Gravanis, Ioannis Charalampopoulos
Published in: Frontiers in Cellular Neuroscience, Issue 18, 2024, ISSN 1662-5102
Publisher: Frontiers Media SA
DOI: 10.3389/FNCEL.2024.1422130

Vision-Based Autonomous Steering of a Miniature Eversion Growing Robot

Author(s): Z. Wu,S.M.H. Sadati, K. Rhode, C. Bergeles
Published in: IEEE Robotics and Automation Letters, Issue 8, 2023, ISSN 2377-3766
Publisher: IEEE
DOI: 10.1109/LRA.2023.3322091

DeepFEA: Deep learning for prediction of transient finite element analysis solutions

Author(s): Georgios Triantafyllou, Panagiotis G. Kalozoumis, George Dimas, Dimitris K. Iakovidis
Published in: Expert Systems with Applications, Issue 269, 2025, ISSN 0957-4174
Publisher: Elsevier BV
DOI: 10.1016/J.ESWA.2024.126343

Pre‐Curved Everting Robots With Embedded Steering Intelligence Fabricated by CO ₂ Laser Welding

Author(s): Brandon Saldarriaga, Panagiotis Kalozoumis, Panagiotis Vartholomeos, Carlo Seneci, Kawal Rhode, Christos Bergeles
Published in: Advanced Intelligent Systems, 2026, ISSN 2640-4567
Publisher: Wiley
DOI: 10.1002/AISY.202501468

Phase‐Change Alloys Enable Localized Reversible Stiffening and Actuation in Steerable Eversion Tip‐Growing Robots

Author(s): Shamsa Al Harthy, S.M.Hadi Sadati, Shannon C. Stockdale, Radhouene Neji, Christos Bergeles
Published in: Advanced Intelligent Systems, Issue 8, 2026, ISSN 2640-4567
Publisher: Wiley
DOI: 10.1002/AISY.202500756

In silico quantification of the stiffness perceived by cells inside porous collagen-based scaffolds

Author(s): Oliver Santos-Lopes, Dimitrios S. Tzeranis, Vasileios Vavourakis
Published in: Materials & Design, Issue 262, 2026, ISSN 0264-1275
Publisher: Elsevier BV
DOI: 10.1016/J.MATDES.2025.115412

Targeting p75NTR activity alleviates the neurotoxic effect of high glucose on iPSC-derived dopaminergic neurons

Author(s): Konstantina Chanoumidou, Ioanna Zota, Maria Anna Papadopoulou, Chrystalla Konstantinou, Alexandros Tsimpolis, Electra Tsagliotis, Maria Tziortziou, Katerina Ntarntani, Anne Grünewald, Matthieu David Lavigne, Achille Gravanis, Ioannis Charalampopoulos
Published in: Stem Cell Research & Therapy, Issue 17, 2026, ISSN 1757-6512
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13287-026-04965-Y

Targeted Delivery of Microneurotrophin <scp>BNN27</scp> via Biomaterial Grafts Protects Retinal Ganglion Cells After Optic Nerve Injury

Author(s): K. Georgelou, E. A. Saridaki, C. P. Apostolidou, X. Mallios, A. Papagiannaki, K. Karali, T. Katsila, T. Calogeropoulou, A. Mitraki, D. Karagogeos, I. Charalampopoulos, A. Gravanis, M. Savvaki, D. S. Tzeranis
Published in: Journal of Biomedical Materials Research Part B: Applied Biomaterials, Issue 114, 2026, ISSN 1552-4973
Publisher: Wiley
DOI: 10.1002/JBMB.70013

Conference proceedings (4)

ArachNet: Interpretable Sub-Arachnoid Space Segmentation Using an Additive Convolutional Neural Network

Author(s): George Dimas, Panagiotis G. Kalozoumis, Panagiotis Vartholomeos, Dimitris K. Iakovidis
Published in: 2024 IEEE International Symposium on Biomedical Imaging (ISBI), 2024
Publisher: IEEE
DOI: 10.1109/ISBI56570.2024.10635787

Multi-Resolution Feature Fusion U-Net for Magnetic Resonance Imaging Segmentation

Author(s): Eirini Cholopoulou, Dimitrios E. Diamantis, Dimitris K. Iakovidis
Published in: 2025 IEEE International Conference on Imaging Systems and Techniques (IST), 2025
Publisher: IEEE
DOI: 10.1109/IST66504.2025.11268425

Lumped Parameter Dynamic Model of an Eversion Growing Robot: Analysis, Simulation and Experimental Validation

Author(s): Panagiotis Vartholomeos, Zicong Wu, S.M. Hadi Sadati, Christos Bergeles
Published in: 2024 IEEE International Conference on Robotics and Automation (ICRA), 2024
Publisher: IEEE
DOI: 10.1109/ICRA57147.2024.10611157

Image-Based Path-Planning for Navigation of Soft-Growing Robots in the Spinal Sub-Arachnoid Space

Author(s): George Dimas, Panagiotis G. Kalozoumis, Panagiotis Vartholomeos, Dimitris K. Iakovidis
Published in: 2024 10th IEEE RAS/EMBS International Conference for Biomedical Robotics and Biomechatronics (BioRob), 2024
Publisher: IEEE
DOI: 10.1109/BIOROB60516.2024.10719744