Minimally-Invasive Soft-Robot-Assisted Deep-Brain Localized Therapeutics Delivery for Neurological Disorders

Información del proyecto

SoftReach

Identificador del acuerdo de subvención: 101099145

DOI

10.3030/101099145

Proyecto cerrado

Fecha de la firma de la CE 21 Noviembre 2022

Fecha de inicio 1 Febrero 2023

Fecha de finalización 31 Julio 2026

Financiado con arreglo a

• The European Innovation Council (EIC)

Coste total

€ 2 158 000,00

Aportación de la UE

€ 2 158 000,00

Coordinado por

IDRYMA TECHNOLOGIAS KAI EREVNAS
Greece

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (6)

Ethics evaluation
Development of map generation & planner
System specifications & architecture
Risk analysis and mitigation plans
Website and project logo

Website and project logo information with also social media links.

Computational models for simulation and control

Demonstrators, pilots, prototypes (1)

Experiment setup for stereotactic delivery of TCPs in mice BV

Publicaciones

Peer reviewed articles (14)

Comprehensive characterization of the neurogenic and neuroprotective action of a novel TrkB agonist using mouse and human stem cell models of Alzheimer’s disease

Autores: Despoina Charou, Thanasis Rogdakis, Alessia Latorrata, Maria Valcarcel, Vasileios Papadogiannis, Christina Athanasiou, Alexandros Tsengenes, Maria Anna Papadopoulou, Dimitrios Lypitkas, Matthieu D. Lavigne, Theodora Katsila, Rebecca C. Wade, M. Zameel Cader, Theodora Calogeropoulou, Achille Gravanis, Ioannis Charalampopoulos
Publicado en: Stem Cell Research & Therapy, Edición 15, 2024, ISSN 1757-6512
Editor: Springer Science and Business Media LLC
DOI: 10.1186/S13287-024-03818-W

Medical & healthcare robotics: a roadmap for enhanced precision, safety, and efficacy

Autores: Dimitris K Iakovidis, Panagiotis Vartholomeos, Alexia Le Gall, Matteo Cianchetti, Oliver Ozioko, Ravinder Dahiya, Evangelos Mazomenos, Francisco Vasconcelos, Danail Stoyanov, Joe Philpott, Taha Erdem, Gerard Cummins, Gastone Ciuti, Carlo A Seneci, Christos Bergeles, Minsoo Kim, Salvador Pané, Bradley J Nelson, Ioannis Poulakakis, Odysseas Simatos, Panagiotis Polygerinos, Petros Toupas, Dimitrios Giakoumis, Dimitrios Tzovaras, Zhidong Su, Weihua Sheng, Andreas S Panayides, Eftychios G Christoforou, Constantinos S Pattichis
Publicado en: Measurement Science and Technology, Edición 36, 2025, ISSN 0957-0233
Editor: IOP Publishing
DOI: 10.1088/1361-6501/AE09BF

Tip-Growing Robots: Design, Theory, Application

Autores: Shamsa Al Harthy, S.M. Hadi Sadati, Cédric Girerd, Sukjun Kim, Alessio Mondini, Zicong Wu, Brandon Saldarriaga, Carlo A. Seneci, Barbara Mazzolai, Tania K. Morimoto, Christos Bergeles
Publicado en: IEEE Transactions on Robotics, Edición 41, 2025, ISSN 1552-3098
Editor: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/TRO.2025.3608701

p75 neurotrophin receptor shapes the dynamics of adult hippocampal neurogenesis in Alzheimer’s disease

Autores: Maria Anna Papadopoulou, Konstantina Chanoumidou, Maria Peteinareli, Electra Tsaglioti, Konstantina Michalaki, Matthieu D. Lavigne, Ioannis Charalampopoulos
Publicado en: Alzheimer's Research & Therapy, Edición 18, 2026, ISSN 1758-9193
Editor: Springer Science and Business Media LLC
DOI: 10.1186/S13195-026-01989-7

Multimodal beneficial effects of BNN27, a nerve growth factor synthetic mimetic, in the 5xFAD mouse model of Alzheimer’s disease

Autores: Maria Kokkali, Kanelina Karali, Evangelia Thanou, Maria Anna Papadopoulou, Ioanna Zota, Alexandros Tsimpolis, Paschalis Efstathopoulos, Theodora Calogeropoulou, Ka Wan Li, Kyriaki Sidiropoulou, Achille Gravanis, Ioannis Charalampopoulos
Publicado en: Molecular Psychiatry, Edición 30, 2025, ISSN 1359-4184
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41380-024-02833-W

An Optical Coupling-Based Method for Catheter Shape Sensing Using Multicore Optical Fiber

Autores: Argyris N. Stassinakis, Panagiotis Vartholomeos
Publicado en: IEEE Sensors Journal, 2026, ISSN 1530-437X
Editor: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/JSEN.2026.3731840

Stimulating myelin restoration with BDNF: a promising therapeutic approach for Alzheimer's disease

Autores: Ioanna Zota, Konstantina Chanoumidou, Achille Gravanis, Ioannis Charalampopoulos
Publicado en: Frontiers in Cellular Neuroscience, Edición 18, 2024, ISSN 1662-5102
Editor: Frontiers Media SA
DOI: 10.3389/FNCEL.2024.1422130

Vision-Based Autonomous Steering of a Miniature Eversion Growing Robot

Autores: Z. Wu,S.M.H. Sadati, K. Rhode, C. Bergeles
Publicado en: IEEE Robotics and Automation Letters, Edición 8, 2023, ISSN 2377-3766
Editor: IEEE
DOI: 10.1109/LRA.2023.3322091

DeepFEA: Deep learning for prediction of transient finite element analysis solutions

Autores: Georgios Triantafyllou, Panagiotis G. Kalozoumis, George Dimas, Dimitris K. Iakovidis
Publicado en: Expert Systems with Applications, Edición 269, 2025, ISSN 0957-4174
Editor: Elsevier BV
DOI: 10.1016/J.ESWA.2024.126343

Pre‐Curved Everting Robots With Embedded Steering Intelligence Fabricated by CO ₂ Laser Welding

Autores: Brandon Saldarriaga, Panagiotis Kalozoumis, Panagiotis Vartholomeos, Carlo Seneci, Kawal Rhode, Christos Bergeles
Publicado en: Advanced Intelligent Systems, 2026, ISSN 2640-4567
Editor: Wiley
DOI: 10.1002/AISY.202501468

Phase‐Change Alloys Enable Localized Reversible Stiffening and Actuation in Steerable Eversion Tip‐Growing Robots

Autores: Shamsa Al Harthy, S.M.Hadi Sadati, Shannon C. Stockdale, Radhouene Neji, Christos Bergeles
Publicado en: Advanced Intelligent Systems, Edición 8, 2026, ISSN 2640-4567
Editor: Wiley
DOI: 10.1002/AISY.202500756

In silico quantification of the stiffness perceived by cells inside porous collagen-based scaffolds

Autores: Oliver Santos-Lopes, Dimitrios S. Tzeranis, Vasileios Vavourakis
Publicado en: Materials & Design, Edición 262, 2026, ISSN 0264-1275
Editor: Elsevier BV
DOI: 10.1016/J.MATDES.2025.115412

Targeting p75NTR activity alleviates the neurotoxic effect of high glucose on iPSC-derived dopaminergic neurons

Autores: Konstantina Chanoumidou, Ioanna Zota, Maria Anna Papadopoulou, Chrystalla Konstantinou, Alexandros Tsimpolis, Electra Tsagliotis, Maria Tziortziou, Katerina Ntarntani, Anne Grünewald, Matthieu David Lavigne, Achille Gravanis, Ioannis Charalampopoulos
Publicado en: Stem Cell Research & Therapy, Edición 17, 2026, ISSN 1757-6512
Editor: Springer Science and Business Media LLC
DOI: 10.1186/S13287-026-04965-Y

Targeted Delivery of Microneurotrophin <scp>BNN27</scp> via Biomaterial Grafts Protects Retinal Ganglion Cells After Optic Nerve Injury

Autores: K. Georgelou, E. A. Saridaki, C. P. Apostolidou, X. Mallios, A. Papagiannaki, K. Karali, T. Katsila, T. Calogeropoulou, A. Mitraki, D. Karagogeos, I. Charalampopoulos, A. Gravanis, M. Savvaki, D. S. Tzeranis
Publicado en: Journal of Biomedical Materials Research Part B: Applied Biomaterials, Edición 114, 2026, ISSN 1552-4973
Editor: Wiley
DOI: 10.1002/JBMB.70013

Conference proceedings (4)

ArachNet: Interpretable Sub-Arachnoid Space Segmentation Using an Additive Convolutional Neural Network

Autores: George Dimas, Panagiotis G. Kalozoumis, Panagiotis Vartholomeos, Dimitris K. Iakovidis
Publicado en: 2024 IEEE International Symposium on Biomedical Imaging (ISBI), 2024
Editor: IEEE
DOI: 10.1109/ISBI56570.2024.10635787

Multi-Resolution Feature Fusion U-Net for Magnetic Resonance Imaging Segmentation

Autores: Eirini Cholopoulou, Dimitrios E. Diamantis, Dimitris K. Iakovidis
Publicado en: 2025 IEEE International Conference on Imaging Systems and Techniques (IST), 2025
Editor: IEEE
DOI: 10.1109/IST66504.2025.11268425

Lumped Parameter Dynamic Model of an Eversion Growing Robot: Analysis, Simulation and Experimental Validation

Autores: Panagiotis Vartholomeos, Zicong Wu, S.M. Hadi Sadati, Christos Bergeles
Publicado en: 2024 IEEE International Conference on Robotics and Automation (ICRA), 2024
Editor: IEEE
DOI: 10.1109/ICRA57147.2024.10611157

Image-Based Path-Planning for Navigation of Soft-Growing Robots in the Spinal Sub-Arachnoid Space

Autores: George Dimas, Panagiotis G. Kalozoumis, Panagiotis Vartholomeos, Dimitris K. Iakovidis
Publicado en: 2024 10th IEEE RAS/EMBS International Conference for Biomedical Robotics and Biomechatronics (BioRob), 2024
Editor: IEEE
DOI: 10.1109/BIOROB60516.2024.10719744