Minimally-Invasive Soft-Robot-Assisted Deep-Brain Localized Therapeutics Delivery for Neurological Disorders

Informacje na temat projektu

SoftReach

Identyfikator umowy o grant: 101099145

DOI

10.3030/101099145

Projekt został zamknięty

Data podpisania przez KE 21 Listopada 2022

Data rozpoczęcia 1 Lutego 2023

Data zakończenia 31 Lipca 2026

Finansowanie w ramach

• The European Innovation Council (EIC)

Koszt całkowity

€ 2 158 000,00

Wkład UE

€ 2 158 000,00

Koordynowany przez

IDRYMA TECHNOLOGIAS KAI EREVNAS
Greece

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (6)

Ethics evaluation
Development of map generation & planner
System specifications & architecture
Risk analysis and mitigation plans
Website and project logo

Website and project logo information with also social media links.

Computational models for simulation and control

Demonstrators, pilots, prototypes (1)

Experiment setup for stereotactic delivery of TCPs in mice BV

Publikacje

Peer reviewed articles (14)

Comprehensive characterization of the neurogenic and neuroprotective action of a novel TrkB agonist using mouse and human stem cell models of Alzheimer’s disease

Autorzy: Despoina Charou, Thanasis Rogdakis, Alessia Latorrata, Maria Valcarcel, Vasileios Papadogiannis, Christina Athanasiou, Alexandros Tsengenes, Maria Anna Papadopoulou, Dimitrios Lypitkas, Matthieu D. Lavigne, Theodora Katsila, Rebecca C. Wade, M. Zameel Cader, Theodora Calogeropoulou, Achille Gravanis, Ioannis Charalampopoulos
Opublikowane w: Stem Cell Research & Therapy, Numer 15, 2024, ISSN 1757-6512
Wydawca: Springer Science and Business Media LLC
DOI: 10.1186/S13287-024-03818-W

Medical & healthcare robotics: a roadmap for enhanced precision, safety, and efficacy

Autorzy: Dimitris K Iakovidis, Panagiotis Vartholomeos, Alexia Le Gall, Matteo Cianchetti, Oliver Ozioko, Ravinder Dahiya, Evangelos Mazomenos, Francisco Vasconcelos, Danail Stoyanov, Joe Philpott, Taha Erdem, Gerard Cummins, Gastone Ciuti, Carlo A Seneci, Christos Bergeles, Minsoo Kim, Salvador Pané, Bradley J Nelson, Ioannis Poulakakis, Odysseas Simatos, Panagiotis Polygerinos, Petros Toupas, Dimitrios Giakoumis, Dimitrios Tzovaras, Zhidong Su, Weihua Sheng, Andreas S Panayides, Eftychios G Christoforou, Constantinos S Pattichis
Opublikowane w: Measurement Science and Technology, Numer 36, 2025, ISSN 0957-0233
Wydawca: IOP Publishing
DOI: 10.1088/1361-6501/AE09BF

Tip-Growing Robots: Design, Theory, Application

Autorzy: Shamsa Al Harthy, S.M. Hadi Sadati, Cédric Girerd, Sukjun Kim, Alessio Mondini, Zicong Wu, Brandon Saldarriaga, Carlo A. Seneci, Barbara Mazzolai, Tania K. Morimoto, Christos Bergeles
Opublikowane w: IEEE Transactions on Robotics, Numer 41, 2025, ISSN 1552-3098
Wydawca: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/TRO.2025.3608701

p75 neurotrophin receptor shapes the dynamics of adult hippocampal neurogenesis in Alzheimer’s disease

Autorzy: Maria Anna Papadopoulou, Konstantina Chanoumidou, Maria Peteinareli, Electra Tsaglioti, Konstantina Michalaki, Matthieu D. Lavigne, Ioannis Charalampopoulos
Opublikowane w: Alzheimer's Research & Therapy, Numer 18, 2026, ISSN 1758-9193
Wydawca: Springer Science and Business Media LLC
DOI: 10.1186/S13195-026-01989-7

Multimodal beneficial effects of BNN27, a nerve growth factor synthetic mimetic, in the 5xFAD mouse model of Alzheimer’s disease

Autorzy: Maria Kokkali, Kanelina Karali, Evangelia Thanou, Maria Anna Papadopoulou, Ioanna Zota, Alexandros Tsimpolis, Paschalis Efstathopoulos, Theodora Calogeropoulou, Ka Wan Li, Kyriaki Sidiropoulou, Achille Gravanis, Ioannis Charalampopoulos
Opublikowane w: Molecular Psychiatry, Numer 30, 2025, ISSN 1359-4184
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S41380-024-02833-W

An Optical Coupling-Based Method for Catheter Shape Sensing Using Multicore Optical Fiber

Autorzy: Argyris N. Stassinakis, Panagiotis Vartholomeos
Opublikowane w: IEEE Sensors Journal, 2026, ISSN 1530-437X
Wydawca: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/JSEN.2026.3731840

Stimulating myelin restoration with BDNF: a promising therapeutic approach for Alzheimer's disease

Autorzy: Ioanna Zota, Konstantina Chanoumidou, Achille Gravanis, Ioannis Charalampopoulos
Opublikowane w: Frontiers in Cellular Neuroscience, Numer 18, 2024, ISSN 1662-5102
Wydawca: Frontiers Media SA
DOI: 10.3389/FNCEL.2024.1422130

Vision-Based Autonomous Steering of a Miniature Eversion Growing Robot

Autorzy: Z. Wu,S.M.H. Sadati, K. Rhode, C. Bergeles
Opublikowane w: IEEE Robotics and Automation Letters, Numer 8, 2023, ISSN 2377-3766
Wydawca: IEEE
DOI: 10.1109/LRA.2023.3322091

DeepFEA: Deep learning for prediction of transient finite element analysis solutions

Autorzy: Georgios Triantafyllou, Panagiotis G. Kalozoumis, George Dimas, Dimitris K. Iakovidis
Opublikowane w: Expert Systems with Applications, Numer 269, 2025, ISSN 0957-4174
Wydawca: Elsevier BV
DOI: 10.1016/J.ESWA.2024.126343

Pre‐Curved Everting Robots With Embedded Steering Intelligence Fabricated by CO ₂ Laser Welding

Autorzy: Brandon Saldarriaga, Panagiotis Kalozoumis, Panagiotis Vartholomeos, Carlo Seneci, Kawal Rhode, Christos Bergeles
Opublikowane w: Advanced Intelligent Systems, 2026, ISSN 2640-4567
Wydawca: Wiley
DOI: 10.1002/AISY.202501468

Phase‐Change Alloys Enable Localized Reversible Stiffening and Actuation in Steerable Eversion Tip‐Growing Robots

Autorzy: Shamsa Al Harthy, S.M.Hadi Sadati, Shannon C. Stockdale, Radhouene Neji, Christos Bergeles
Opublikowane w: Advanced Intelligent Systems, Numer 8, 2026, ISSN 2640-4567
Wydawca: Wiley
DOI: 10.1002/AISY.202500756

In silico quantification of the stiffness perceived by cells inside porous collagen-based scaffolds

Autorzy: Oliver Santos-Lopes, Dimitrios S. Tzeranis, Vasileios Vavourakis
Opublikowane w: Materials & Design, Numer 262, 2026, ISSN 0264-1275
Wydawca: Elsevier BV
DOI: 10.1016/J.MATDES.2025.115412

Targeting p75NTR activity alleviates the neurotoxic effect of high glucose on iPSC-derived dopaminergic neurons

Autorzy: Konstantina Chanoumidou, Ioanna Zota, Maria Anna Papadopoulou, Chrystalla Konstantinou, Alexandros Tsimpolis, Electra Tsagliotis, Maria Tziortziou, Katerina Ntarntani, Anne Grünewald, Matthieu David Lavigne, Achille Gravanis, Ioannis Charalampopoulos
Opublikowane w: Stem Cell Research & Therapy, Numer 17, 2026, ISSN 1757-6512
Wydawca: Springer Science and Business Media LLC
DOI: 10.1186/S13287-026-04965-Y

Targeted Delivery of Microneurotrophin <scp>BNN27</scp> via Biomaterial Grafts Protects Retinal Ganglion Cells After Optic Nerve Injury

Autorzy: K. Georgelou, E. A. Saridaki, C. P. Apostolidou, X. Mallios, A. Papagiannaki, K. Karali, T. Katsila, T. Calogeropoulou, A. Mitraki, D. Karagogeos, I. Charalampopoulos, A. Gravanis, M. Savvaki, D. S. Tzeranis
Opublikowane w: Journal of Biomedical Materials Research Part B: Applied Biomaterials, Numer 114, 2026, ISSN 1552-4973
Wydawca: Wiley
DOI: 10.1002/JBMB.70013

Conference proceedings (4)

ArachNet: Interpretable Sub-Arachnoid Space Segmentation Using an Additive Convolutional Neural Network

Autorzy: George Dimas, Panagiotis G. Kalozoumis, Panagiotis Vartholomeos, Dimitris K. Iakovidis
Opublikowane w: 2024 IEEE International Symposium on Biomedical Imaging (ISBI), 2024
Wydawca: IEEE
DOI: 10.1109/ISBI56570.2024.10635787

Multi-Resolution Feature Fusion U-Net for Magnetic Resonance Imaging Segmentation

Autorzy: Eirini Cholopoulou, Dimitrios E. Diamantis, Dimitris K. Iakovidis
Opublikowane w: 2025 IEEE International Conference on Imaging Systems and Techniques (IST), 2025
Wydawca: IEEE
DOI: 10.1109/IST66504.2025.11268425

Lumped Parameter Dynamic Model of an Eversion Growing Robot: Analysis, Simulation and Experimental Validation

Autorzy: Panagiotis Vartholomeos, Zicong Wu, S.M. Hadi Sadati, Christos Bergeles
Opublikowane w: 2024 IEEE International Conference on Robotics and Automation (ICRA), 2024
Wydawca: IEEE
DOI: 10.1109/ICRA57147.2024.10611157

Image-Based Path-Planning for Navigation of Soft-Growing Robots in the Spinal Sub-Arachnoid Space

Autorzy: George Dimas, Panagiotis G. Kalozoumis, Panagiotis Vartholomeos, Dimitris K. Iakovidis
Opublikowane w: 2024 10th IEEE RAS/EMBS International Conference for Biomedical Robotics and Biomechatronics (BioRob), 2024
Wydawca: IEEE
DOI: 10.1109/BIOROB60516.2024.10719744