Minimally-Invasive Soft-Robot-Assisted Deep-Brain Localized Therapeutics Delivery for Neurological Disorders

Informazioni relative al progetto

SoftReach

ID dell’accordo di sovvenzione: 101099145

DOI

10.3030/101099145

Progetto chiuso

Data della firma CE 21 Novembre 2022

Data di avvio 1 Febbraio 2023

Data di completamento 31 Luglio 2026

Finanziato da

• The European Innovation Council (EIC)

Costo totale

€ 2 158 000,00

Contributo UE

€ 2 158 000,00

Coordinato da

IDRYMA TECHNOLOGIAS KAI EREVNAS
Greece

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (6)

Ethics evaluation
Development of map generation & planner
System specifications & architecture
Risk analysis and mitigation plans
Website and project logo

Website and project logo information with also social media links.

Computational models for simulation and control

Demonstrators, pilots, prototypes (1)

Experiment setup for stereotactic delivery of TCPs in mice BV

Pubblicazioni

Peer reviewed articles (14)

Comprehensive characterization of the neurogenic and neuroprotective action of a novel TrkB agonist using mouse and human stem cell models of Alzheimer’s disease

Autori: Despoina Charou, Thanasis Rogdakis, Alessia Latorrata, Maria Valcarcel, Vasileios Papadogiannis, Christina Athanasiou, Alexandros Tsengenes, Maria Anna Papadopoulou, Dimitrios Lypitkas, Matthieu D. Lavigne, Theodora Katsila, Rebecca C. Wade, M. Zameel Cader, Theodora Calogeropoulou, Achille Gravanis, Ioannis Charalampopoulos
Pubblicato in: Stem Cell Research & Therapy, Numero 15, 2024, ISSN 1757-6512
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S13287-024-03818-W

Medical & healthcare robotics: a roadmap for enhanced precision, safety, and efficacy

Autori: Dimitris K Iakovidis, Panagiotis Vartholomeos, Alexia Le Gall, Matteo Cianchetti, Oliver Ozioko, Ravinder Dahiya, Evangelos Mazomenos, Francisco Vasconcelos, Danail Stoyanov, Joe Philpott, Taha Erdem, Gerard Cummins, Gastone Ciuti, Carlo A Seneci, Christos Bergeles, Minsoo Kim, Salvador Pané, Bradley J Nelson, Ioannis Poulakakis, Odysseas Simatos, Panagiotis Polygerinos, Petros Toupas, Dimitrios Giakoumis, Dimitrios Tzovaras, Zhidong Su, Weihua Sheng, Andreas S Panayides, Eftychios G Christoforou, Constantinos S Pattichis
Pubblicato in: Measurement Science and Technology, Numero 36, 2025, ISSN 0957-0233
Editore: IOP Publishing
DOI: 10.1088/1361-6501/AE09BF

Tip-Growing Robots: Design, Theory, Application

Autori: Shamsa Al Harthy, S.M. Hadi Sadati, Cédric Girerd, Sukjun Kim, Alessio Mondini, Zicong Wu, Brandon Saldarriaga, Carlo A. Seneci, Barbara Mazzolai, Tania K. Morimoto, Christos Bergeles
Pubblicato in: IEEE Transactions on Robotics, Numero 41, 2025, ISSN 1552-3098
Editore: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/TRO.2025.3608701

p75 neurotrophin receptor shapes the dynamics of adult hippocampal neurogenesis in Alzheimer’s disease

Autori: Maria Anna Papadopoulou, Konstantina Chanoumidou, Maria Peteinareli, Electra Tsaglioti, Konstantina Michalaki, Matthieu D. Lavigne, Ioannis Charalampopoulos
Pubblicato in: Alzheimer's Research & Therapy, Numero 18, 2026, ISSN 1758-9193
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S13195-026-01989-7

Multimodal beneficial effects of BNN27, a nerve growth factor synthetic mimetic, in the 5xFAD mouse model of Alzheimer’s disease

Autori: Maria Kokkali, Kanelina Karali, Evangelia Thanou, Maria Anna Papadopoulou, Ioanna Zota, Alexandros Tsimpolis, Paschalis Efstathopoulos, Theodora Calogeropoulou, Ka Wan Li, Kyriaki Sidiropoulou, Achille Gravanis, Ioannis Charalampopoulos
Pubblicato in: Molecular Psychiatry, Numero 30, 2025, ISSN 1359-4184
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41380-024-02833-W

An Optical Coupling-Based Method for Catheter Shape Sensing Using Multicore Optical Fiber

Autori: Argyris N. Stassinakis, Panagiotis Vartholomeos
Pubblicato in: IEEE Sensors Journal, 2026, ISSN 1530-437X
Editore: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/JSEN.2026.3731840

Stimulating myelin restoration with BDNF: a promising therapeutic approach for Alzheimer's disease

Autori: Ioanna Zota, Konstantina Chanoumidou, Achille Gravanis, Ioannis Charalampopoulos
Pubblicato in: Frontiers in Cellular Neuroscience, Numero 18, 2024, ISSN 1662-5102
Editore: Frontiers Media SA
DOI: 10.3389/FNCEL.2024.1422130

Vision-Based Autonomous Steering of a Miniature Eversion Growing Robot

Autori: Z. Wu,S.M.H. Sadati, K. Rhode, C. Bergeles
Pubblicato in: IEEE Robotics and Automation Letters, Numero 8, 2023, ISSN 2377-3766
Editore: IEEE
DOI: 10.1109/LRA.2023.3322091

DeepFEA: Deep learning for prediction of transient finite element analysis solutions

Autori: Georgios Triantafyllou, Panagiotis G. Kalozoumis, George Dimas, Dimitris K. Iakovidis
Pubblicato in: Expert Systems with Applications, Numero 269, 2025, ISSN 0957-4174
Editore: Elsevier BV
DOI: 10.1016/J.ESWA.2024.126343

Pre‐Curved Everting Robots With Embedded Steering Intelligence Fabricated by CO ₂ Laser Welding

Autori: Brandon Saldarriaga, Panagiotis Kalozoumis, Panagiotis Vartholomeos, Carlo Seneci, Kawal Rhode, Christos Bergeles
Pubblicato in: Advanced Intelligent Systems, 2026, ISSN 2640-4567
Editore: Wiley
DOI: 10.1002/AISY.202501468

Phase‐Change Alloys Enable Localized Reversible Stiffening and Actuation in Steerable Eversion Tip‐Growing Robots

Autori: Shamsa Al Harthy, S.M.Hadi Sadati, Shannon C. Stockdale, Radhouene Neji, Christos Bergeles
Pubblicato in: Advanced Intelligent Systems, Numero 8, 2026, ISSN 2640-4567
Editore: Wiley
DOI: 10.1002/AISY.202500756

In silico quantification of the stiffness perceived by cells inside porous collagen-based scaffolds

Autori: Oliver Santos-Lopes, Dimitrios S. Tzeranis, Vasileios Vavourakis
Pubblicato in: Materials & Design, Numero 262, 2026, ISSN 0264-1275
Editore: Elsevier BV
DOI: 10.1016/J.MATDES.2025.115412

Targeting p75NTR activity alleviates the neurotoxic effect of high glucose on iPSC-derived dopaminergic neurons

Autori: Konstantina Chanoumidou, Ioanna Zota, Maria Anna Papadopoulou, Chrystalla Konstantinou, Alexandros Tsimpolis, Electra Tsagliotis, Maria Tziortziou, Katerina Ntarntani, Anne Grünewald, Matthieu David Lavigne, Achille Gravanis, Ioannis Charalampopoulos
Pubblicato in: Stem Cell Research & Therapy, Numero 17, 2026, ISSN 1757-6512
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S13287-026-04965-Y

Targeted Delivery of Microneurotrophin <scp>BNN27</scp> via Biomaterial Grafts Protects Retinal Ganglion Cells After Optic Nerve Injury

Autori: K. Georgelou, E. A. Saridaki, C. P. Apostolidou, X. Mallios, A. Papagiannaki, K. Karali, T. Katsila, T. Calogeropoulou, A. Mitraki, D. Karagogeos, I. Charalampopoulos, A. Gravanis, M. Savvaki, D. S. Tzeranis
Pubblicato in: Journal of Biomedical Materials Research Part B: Applied Biomaterials, Numero 114, 2026, ISSN 1552-4973
Editore: Wiley
DOI: 10.1002/JBMB.70013

Conference proceedings (4)

ArachNet: Interpretable Sub-Arachnoid Space Segmentation Using an Additive Convolutional Neural Network

Autori: George Dimas, Panagiotis G. Kalozoumis, Panagiotis Vartholomeos, Dimitris K. Iakovidis
Pubblicato in: 2024 IEEE International Symposium on Biomedical Imaging (ISBI), 2024
Editore: IEEE
DOI: 10.1109/ISBI56570.2024.10635787

Multi-Resolution Feature Fusion U-Net for Magnetic Resonance Imaging Segmentation

Autori: Eirini Cholopoulou, Dimitrios E. Diamantis, Dimitris K. Iakovidis
Pubblicato in: 2025 IEEE International Conference on Imaging Systems and Techniques (IST), 2025
Editore: IEEE
DOI: 10.1109/IST66504.2025.11268425

Lumped Parameter Dynamic Model of an Eversion Growing Robot: Analysis, Simulation and Experimental Validation

Autori: Panagiotis Vartholomeos, Zicong Wu, S.M. Hadi Sadati, Christos Bergeles
Pubblicato in: 2024 IEEE International Conference on Robotics and Automation (ICRA), 2024
Editore: IEEE
DOI: 10.1109/ICRA57147.2024.10611157

Image-Based Path-Planning for Navigation of Soft-Growing Robots in the Spinal Sub-Arachnoid Space

Autori: George Dimas, Panagiotis G. Kalozoumis, Panagiotis Vartholomeos, Dimitris K. Iakovidis
Pubblicato in: 2024 10th IEEE RAS/EMBS International Conference for Biomedical Robotics and Biomechatronics (BioRob), 2024
Editore: IEEE
DOI: 10.1109/BIOROB60516.2024.10719744