Minimally-Invasive Soft-Robot-Assisted Deep-Brain Localized Therapeutics Delivery for Neurological Disorders

Informations projet

SoftReach

N° de convention de subvention: 101099145

DOI

10.3030/101099145

Projet clôturé

Date de signature de la CE 21 Novembre 2022

Date de début 1 Février 2023

Date de fin 31 Juillet 2026

Financé au titre de

• The European Innovation Council (EIC)

Coût total

€ 2 158 000,00

Contribution de l’UE

€ 2 158 000,00

Coordonné par

IDRYMA TECHNOLOGIAS KAI EREVNAS
Greece

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (6)

Ethics evaluation
Development of map generation & planner
System specifications & architecture
Risk analysis and mitigation plans
Website and project logo

Website and project logo information with also social media links.

Computational models for simulation and control

Demonstrators, pilots, prototypes (1)

Experiment setup for stereotactic delivery of TCPs in mice BV

Publications

Peer reviewed articles (14)

Comprehensive characterization of the neurogenic and neuroprotective action of a novel TrkB agonist using mouse and human stem cell models of Alzheimer’s disease

Auteurs: Despoina Charou, Thanasis Rogdakis, Alessia Latorrata, Maria Valcarcel, Vasileios Papadogiannis, Christina Athanasiou, Alexandros Tsengenes, Maria Anna Papadopoulou, Dimitrios Lypitkas, Matthieu D. Lavigne, Theodora Katsila, Rebecca C. Wade, M. Zameel Cader, Theodora Calogeropoulou, Achille Gravanis, Ioannis Charalampopoulos
Publié dans: Stem Cell Research & Therapy, Numéro 15, 2024, ISSN 1757-6512
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S13287-024-03818-W

Medical & healthcare robotics: a roadmap for enhanced precision, safety, and efficacy

Auteurs: Dimitris K Iakovidis, Panagiotis Vartholomeos, Alexia Le Gall, Matteo Cianchetti, Oliver Ozioko, Ravinder Dahiya, Evangelos Mazomenos, Francisco Vasconcelos, Danail Stoyanov, Joe Philpott, Taha Erdem, Gerard Cummins, Gastone Ciuti, Carlo A Seneci, Christos Bergeles, Minsoo Kim, Salvador Pané, Bradley J Nelson, Ioannis Poulakakis, Odysseas Simatos, Panagiotis Polygerinos, Petros Toupas, Dimitrios Giakoumis, Dimitrios Tzovaras, Zhidong Su, Weihua Sheng, Andreas S Panayides, Eftychios G Christoforou, Constantinos S Pattichis
Publié dans: Measurement Science and Technology, Numéro 36, 2025, ISSN 0957-0233
Éditeur: IOP Publishing
DOI: 10.1088/1361-6501/AE09BF

Tip-Growing Robots: Design, Theory, Application

Auteurs: Shamsa Al Harthy, S.M. Hadi Sadati, Cédric Girerd, Sukjun Kim, Alessio Mondini, Zicong Wu, Brandon Saldarriaga, Carlo A. Seneci, Barbara Mazzolai, Tania K. Morimoto, Christos Bergeles
Publié dans: IEEE Transactions on Robotics, Numéro 41, 2025, ISSN 1552-3098
Éditeur: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/TRO.2025.3608701

p75 neurotrophin receptor shapes the dynamics of adult hippocampal neurogenesis in Alzheimer’s disease

Auteurs: Maria Anna Papadopoulou, Konstantina Chanoumidou, Maria Peteinareli, Electra Tsaglioti, Konstantina Michalaki, Matthieu D. Lavigne, Ioannis Charalampopoulos
Publié dans: Alzheimer's Research & Therapy, Numéro 18, 2026, ISSN 1758-9193
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S13195-026-01989-7

Multimodal beneficial effects of BNN27, a nerve growth factor synthetic mimetic, in the 5xFAD mouse model of Alzheimer’s disease

Auteurs: Maria Kokkali, Kanelina Karali, Evangelia Thanou, Maria Anna Papadopoulou, Ioanna Zota, Alexandros Tsimpolis, Paschalis Efstathopoulos, Theodora Calogeropoulou, Ka Wan Li, Kyriaki Sidiropoulou, Achille Gravanis, Ioannis Charalampopoulos
Publié dans: Molecular Psychiatry, Numéro 30, 2025, ISSN 1359-4184
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41380-024-02833-W

An Optical Coupling-Based Method for Catheter Shape Sensing Using Multicore Optical Fiber

Auteurs: Argyris N. Stassinakis, Panagiotis Vartholomeos
Publié dans: IEEE Sensors Journal, 2026, ISSN 1530-437X
Éditeur: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/JSEN.2026.3731840

Stimulating myelin restoration with BDNF: a promising therapeutic approach for Alzheimer's disease

Auteurs: Ioanna Zota, Konstantina Chanoumidou, Achille Gravanis, Ioannis Charalampopoulos
Publié dans: Frontiers in Cellular Neuroscience, Numéro 18, 2024, ISSN 1662-5102
Éditeur: Frontiers Media SA
DOI: 10.3389/FNCEL.2024.1422130

Vision-Based Autonomous Steering of a Miniature Eversion Growing Robot

Auteurs: Z. Wu,S.M.H. Sadati, K. Rhode, C. Bergeles
Publié dans: IEEE Robotics and Automation Letters, Numéro 8, 2023, ISSN 2377-3766
Éditeur: IEEE
DOI: 10.1109/LRA.2023.3322091

DeepFEA: Deep learning for prediction of transient finite element analysis solutions

Auteurs: Georgios Triantafyllou, Panagiotis G. Kalozoumis, George Dimas, Dimitris K. Iakovidis
Publié dans: Expert Systems with Applications, Numéro 269, 2025, ISSN 0957-4174
Éditeur: Elsevier BV
DOI: 10.1016/J.ESWA.2024.126343

Pre‐Curved Everting Robots With Embedded Steering Intelligence Fabricated by CO ₂ Laser Welding

Auteurs: Brandon Saldarriaga, Panagiotis Kalozoumis, Panagiotis Vartholomeos, Carlo Seneci, Kawal Rhode, Christos Bergeles
Publié dans: Advanced Intelligent Systems, 2026, ISSN 2640-4567
Éditeur: Wiley
DOI: 10.1002/AISY.202501468

Phase‐Change Alloys Enable Localized Reversible Stiffening and Actuation in Steerable Eversion Tip‐Growing Robots

Auteurs: Shamsa Al Harthy, S.M.Hadi Sadati, Shannon C. Stockdale, Radhouene Neji, Christos Bergeles
Publié dans: Advanced Intelligent Systems, Numéro 8, 2026, ISSN 2640-4567
Éditeur: Wiley
DOI: 10.1002/AISY.202500756

In silico quantification of the stiffness perceived by cells inside porous collagen-based scaffolds

Auteurs: Oliver Santos-Lopes, Dimitrios S. Tzeranis, Vasileios Vavourakis
Publié dans: Materials & Design, Numéro 262, 2026, ISSN 0264-1275
Éditeur: Elsevier BV
DOI: 10.1016/J.MATDES.2025.115412

Targeting p75NTR activity alleviates the neurotoxic effect of high glucose on iPSC-derived dopaminergic neurons

Auteurs: Konstantina Chanoumidou, Ioanna Zota, Maria Anna Papadopoulou, Chrystalla Konstantinou, Alexandros Tsimpolis, Electra Tsagliotis, Maria Tziortziou, Katerina Ntarntani, Anne Grünewald, Matthieu David Lavigne, Achille Gravanis, Ioannis Charalampopoulos
Publié dans: Stem Cell Research & Therapy, Numéro 17, 2026, ISSN 1757-6512
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S13287-026-04965-Y

Targeted Delivery of Microneurotrophin <scp>BNN27</scp> via Biomaterial Grafts Protects Retinal Ganglion Cells After Optic Nerve Injury

Auteurs: K. Georgelou, E. A. Saridaki, C. P. Apostolidou, X. Mallios, A. Papagiannaki, K. Karali, T. Katsila, T. Calogeropoulou, A. Mitraki, D. Karagogeos, I. Charalampopoulos, A. Gravanis, M. Savvaki, D. S. Tzeranis
Publié dans: Journal of Biomedical Materials Research Part B: Applied Biomaterials, Numéro 114, 2026, ISSN 1552-4973
Éditeur: Wiley
DOI: 10.1002/JBMB.70013

Conference proceedings (4)

ArachNet: Interpretable Sub-Arachnoid Space Segmentation Using an Additive Convolutional Neural Network

Auteurs: George Dimas, Panagiotis G. Kalozoumis, Panagiotis Vartholomeos, Dimitris K. Iakovidis
Publié dans: 2024 IEEE International Symposium on Biomedical Imaging (ISBI), 2024
Éditeur: IEEE
DOI: 10.1109/ISBI56570.2024.10635787

Multi-Resolution Feature Fusion U-Net for Magnetic Resonance Imaging Segmentation

Auteurs: Eirini Cholopoulou, Dimitrios E. Diamantis, Dimitris K. Iakovidis
Publié dans: 2025 IEEE International Conference on Imaging Systems and Techniques (IST), 2025
Éditeur: IEEE
DOI: 10.1109/IST66504.2025.11268425

Lumped Parameter Dynamic Model of an Eversion Growing Robot: Analysis, Simulation and Experimental Validation

Auteurs: Panagiotis Vartholomeos, Zicong Wu, S.M. Hadi Sadati, Christos Bergeles
Publié dans: 2024 IEEE International Conference on Robotics and Automation (ICRA), 2024
Éditeur: IEEE
DOI: 10.1109/ICRA57147.2024.10611157

Image-Based Path-Planning for Navigation of Soft-Growing Robots in the Spinal Sub-Arachnoid Space

Auteurs: George Dimas, Panagiotis G. Kalozoumis, Panagiotis Vartholomeos, Dimitris K. Iakovidis
Publié dans: 2024 10th IEEE RAS/EMBS International Conference for Biomedical Robotics and Biomechatronics (BioRob), 2024
Éditeur: IEEE
DOI: 10.1109/BIOROB60516.2024.10719744