Characterizing ligand-protein interactions with a cryo-EM data-driven modeling approach

Informazioni relative al progetto

CryoLigate

ID dell’accordo di sovvenzione: 101107036

DOI

10.3030/101107036

Data della firma CE 21 Aprile 2023

Data di avvio 1 Novembre 2023

Data di completamento 31 Ottobre 2025

Finanziato da

• Marie Skłodowska-Curie Actions (MSCA)

Costo totale

Nessun dato

Contributo UE

€ 222 727,68

Coordinato da

KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (2)

Communication, Dissemination & Exploitation Plan

The plan describes the planned measures to maximize the impact of the project, including the dissemination and exploitation measures that are planned, and the target group(s) addressed. Regarding communication measures and public engagement strategy, the aim is to inform and reach out to society and show the activities performed, and the use and the benefits the project will have for citizens.

Data Management Plan

Data Management Plan Description: The Data Management Plan describes the data management life cycle for all data sets that will be collected, processed or generated by the action. It is a document describing what data will be collected, processed or generated and following what methodology and standards, whether and how this data will be shared and/or made open, and how it will be curated and preserved.

Pubblicazioni

Peer reviewed articles (6)

Resolving the conformational ensemble of a membrane protein by integrating small-angle scattering with AlphaFold

Autori: Samuel Eriksson Lidbrink, Rebecca J. Howard, Nandan Haloi, Erik Lindahl
Pubblicato in: PLOS Computational Biology, Numero 21(7): e1013187, 2025, ISSN 1553-7358
Editore: PLOS
DOI: 10.1371/JOURNAL.PCBI.1013187

Structure and dynamics of differential ligand binding in the human ρ-type GABAA receptor

Autori: John Cowgill, Chen Fan, Nandan Haloi, Victor Tobiasson, Yuxuan Zhuang, Rebecca J. Howard, Erik Lindahl
Pubblicato in: Neuron, 2023, ISSN 1097-4199
Editore: Elsevier
DOI: 10.1016/j.neuron.2023.08.006

Discovering cryptic pocket opening and binding of a stimulant derivative in a vestibular site of the 5-HT _3A receptor

Autori: Nandan Haloi, Emelia Karlsson, Marc Delarue, Rebecca J. Howard, Erik Lindahl
Pubblicato in: Science Advances, Numero 11, 2025, ISSN 2375-2548
Editore: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.ADR0797

Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids

Autori: Nandan Haloi, Shan Huang, Aaron L Nichols, Eve J Fine, Nicholas J Friesenhahn, Christopher B Marotta, Dennis A Dougherty, Erik Lindahl, Rebecca J Howard, Stephen L Mayo, Henry A Lester
Pubblicato in: Protein Engineering, Design and Selection, 2024, ISSN 1741-0134
Editore: oxford university press
DOI: 10.1093/protein/gzae003

Adaptive sampling–based structural prediction reveals opening of a GABA _A receptor through the αβ interface

Autori: Nandan Haloi, Samuel Eriksson Lidbrink, Rebecca J. Howard, Erik Lindahl
Pubblicato in: Science Advances, Numero 11, 2025, ISSN 2375-2548
Editore: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.adq3788

Cryo-EM ligand building using AlphaFold3-like model and molecular dynamics

Autori: Nandan Haloi, Rebecca J. Howard, Erik Lindahl
Pubblicato in: PLOS Computational Biology, Numero 21(8): e1013367, 2025, ISSN 1553-7358
Editore: plos
DOI: 10.1371/JOURNAL.PCBI.1013367