Descrizione del progetto
Previsione innovativa per la malattia cardiovascolare aterosclerotica
La malattia cardiovascolare aterosclerotica (MCA) è la prima causa di morte a livello globale. Il passaggio cruciale per prevenirne le conseguenze fatali è identificare gli individui ad alto rischio. Tuttavia, i modelli di previsione del rischio esistenti, come lo SCORE2, hanno dei limiti che impediscono di includere tutti i meccanismi e i fenotipi che causano la malattia. Il progetto MIRACLE, finanziato dall’UE, si propone di colmare questa lacuna sviluppando nuovi modelli di previsione per la MCA utilizzando dati multiomici. Il progetto individuerà i loci genetici che differenziano la cardiopatia coronarica, l’arteriopatia periferica e l’ictus, creando punteggi di rischio poligenici. Tramite la fenotipizzazione trascrittomica e la modellazione ad apprendimento profondo, saranno definiti modelli di previsione del rischio che incorporino il rischio poligenico e i biomarcatori circolanti. Questa innovazione tecnologica facilita le diagnosi e i trattamenti più precoci della MCA.
Obiettivo
Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of mortality worldwide. Aside from asymptomatic manifestations, the first sign of clinically significant ASCVD is often a severe clinical event, such as stroke or myocardial infarction (MI). Thus, identifying individuals at high risk is crucial in preventing the fatal consequences of ASCVD. Current risk prediction models based on traditional risk factors, such as SCORE2, have limitations since they do not encompass all mechanisms and intermediary phenotypes leading to ASCVD. Particularly, current risk models fail to consider the disturbance of gene regulatory networks (GRNs) caused by genetic risk factors and diverse longitudinal exposures accumulating during a person's lifetime.Furthermore the current models predict the combined risk of CAD, PAD and ischemic stroke despite mounting evidence of the heterogeneity of the underlying disease mechanisms. To capture the missing aspects of current ASCVD risk scores, MIRACLE project brings together unique data resources and expertise to provide novel multiomics based prediction models of ASCVD. We aim to (1) Integrate the globally largest CAD, PAD, and stroke GWAS information to identify genetic loci that differ between or are shared by these diseases and their subtypes, (2) Identify sex-specific subtypes of ASCVD patients using transcriptomic phenotyping of plaques and circulating biomarkers, (3) Generate functionally informed polygenic risk scores by combining experimental fine-mapping and gene prioritization approaches with integrative GRN and deep learning modelling. (4) Derive novel risk prediction models incorporating polygenic risk and circulating biomarkers. Providing a new gold standard for prediction models to accurately risk stratify stroke and MI represents a technological breakthrough allowing for earlier diagnoses and treatments of ASCVD.
Campo scientifico
Parole chiave
Programma(i)
- HORIZON.3.1 - The European Innovation Council (EIC) Main Programme
Invito a presentare proposte
HORIZON-EIC-2022-PATHFINDERCHALLENGES-01
Vedi altri progetti per questo bandoMeccanismo di finanziamento
HORIZON-EIC - HORIZON EIC GrantsCoordinatore
70211 KUOPIO
Finlandia