Enabling personalised diagnosis, treatment, and stratification through whole-body metabolic modelling of an individual’s genome, metabolome, and metagenome.

Project Information

AVATAR

Grant agreement ID: 101125633

DOI

10.3030/101125633

EC signature date 15 March 2024

Start date 1 April 2024

End date 31 March 2029

Funded under

• European Research Council (ERC)

Total cost

€ 1 999 991,00

EU contribution

€ 1 999 991,00

Coordinated by

UNIVERSITY OF GALWAY
Ireland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

MicroMap: a network visualisation resource for human microbiome metabolism

Author(s): Cyrille C. Thinnes, Renee Waschkowitz, Eoghan Courtney, Eoghan Culligan, Katie Fahy, Ruby A. M. Ferrazza, Ciara Ferris, Angeline Lagali, Rebecca Lane, Colm Maye, Olivia Murphy, David Noone, Saoirse Ryan, Mihaela Bet, Maria C. Corr, Hannah Cummins, David Hackett, Ellen Healy, Nina Kulczycka, Niall Lang, Luke Madden, Lynne McHugh, Ivana Pyne, Ciara Varley, Niamh Harkin, Ronan Meade, Grace O’Donnell, Bram Nap, Filippo Martinelli, Almut Heinken, Ines Thiele
Published in: npj Biofilms and Microbiomes, Issue 11, 2025, ISSN 2055-5008
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41522-025-00853-0

Personalized metabolic whole-body models for newborns and infants predict growth and biomarkers of inherited metabolic diseases

Author(s): Elaine Zaunseder, Ulrike Mütze, Jürgen G. Okun, Georg F. Hoffmann, Stefan Kölker, Vincent Heuveline, Ines Thiele
Published in: Cell Metabolism, Issue 36, 2024, ISSN 1550-4131
Publisher: Elsevier BV
DOI: 10.1016/j.cmet.2024.05.006

Characterisation of conserved and reacting moieties in chemical reaction networks

Author(s): Hadjar Rahou, Hulda S. Haraldsdóttir, Filippo Martinelli, Ines Thiele, Ronan M.T. Fleming
Published in: Journal of Theoretical Biology, Issue 621, 2026, ISSN 0022-5193
Publisher: Elsevier BV
DOI: 10.1016/J.JTBI.2025.112348

A genome-scale metabolic reconstruction resource of 247,092 diverse human microbes spanning multiple continents, age groups, and body sites

Author(s): Almut Heinken, Timothy Otto Hulshof, Bram Nap, Filippo Martinelli, Arianna Basile, Amy O’Brolchain, Neil Francis O’Sullivan, Celine Gallagher, Eimer Magee, Francesca McDonagh, Ian Lalor, Maeve Bergin, Phoebe Evans, Rachel Daly, Ronan Farrell, Rose Mary Delaney, Saoirse Hill, Saoirse Roisin McAuliffe, Trevor Kilgannon, Ronan M.T. Fleming, Cyrille C. Thinnes, Ines Thiele
Published in: Cell Systems, Issue 16, 2025, ISSN 2405-4712
Publisher: Elsevier BV
DOI: 10.1016/J.CELS.2025.101196EXTERNALLINK

The nutrition toolbox permits in silico generation, analysis, and optimization of personalized diets through metabolic modelling

Author(s): Bram Nap, Bronson Weston, Annette Brandt, Maximilian F Wodak, Ina Bergheim, Ines Thiele
Published in: Bioinformatics advances, ISSN 2635-0041
Publisher: Bioinformatics advances
DOI: 10.1093/BIOADV/VBAF325

In silico metabolic modelling links microbiome-derived metabolites to risk factors of Alzheimer’s disease

Author(s): Tim Hensen, Shahzad Ahmad, Gabi Kastenmüller, Robert Kraaij, Mohsen Ghanbari, Arfan Ikram, Rima Kaddurah-Daouk, Ines Thiele
Published in: Gut Microbes Reports, Issue 2, 2025, ISSN 2993-3935
Publisher: Informa UK Limited
DOI: 10.1080/29933935.2024.2443171

XomicsToModel: omics data integration and generation of thermodynamically consistent metabolic models

Author(s): German Preciat, Agnieszka B. Wegrzyn, Xi Luo, Ines Thiele, Thomas Hankemeier, Ronan M. T. Fleming
Published in: Nature Protocols, 2025, ISSN 1754-2189
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41596-025-01288-9

Microbial Abundances Retrieved from Sequencing data—automated NCBI Taxonomy (MARS): a pipeline to create relative microbial abundance data for the Microbiome Modelling Toolbox and utilizing homosynonyms for efficient mapping to resources

Author(s): Tim Hulshof, Bram Nap, Filippo Martinelli, Ines Thiele
Published in: Bioinformatics Advances, Issue 4, 2024, ISSN 2635-0041
Publisher: Oxford University Press (OUP)
DOI: 10.1093/bioadv/vbae068